Ercc1 - excision repair cross-complementing rodent repair deficiency, complementation group 1 Gene

种属: Mus musculus

同用名: Ercc-1

关于 Ercc1

功能概要

Enables TFIID-class transcription factor complex binding activity and promoter-specific chromatin binding activity. Involved in positive regulation of t-circle formation and t-circle formation. Acts upstream of or within several processes, including DNA metabolic process; UV protection; and gamete generation. Predicted to be located in chromosome, telomeric region and nucleoplasm. Predicted to be part of ERCC4-ERCC1 complex and nucleotide-excision repair factor 1 complex. Is expressed in brain; cerebral cortex; and telencephalon. Used to study XFE progeroid syndrome. Human ortholog(s) of this gene implicated in several diseases, including bone Cancer (multiple); carcinoma (multiple); cerebrooculofacioskeletal syndrome 4; hematologic Cancer (multiple); and transient cerebral ischemia. Orthologous to human ERCC1 (ERCC excision repair 1, Endonuclease non-catalytic subunit). [provided by Alliance of Genome Resources, Apr 2022]