Grm8 - glutamate receptor, metabotropic 8 Gene

中文名称：谷氨酸受体，代谢型 8

种属: Mus musculus

同用名: GluR8; Gprc1h; mGluR8; A230002O04

关于 Grm8

功能概要

该基因编码的蛋白可启动 III 组代谢型谷氨酸受体活性。预计参与多个过程，包括腺苷酸环化酶抑制G蛋白偶联谷氨酸受体信号通路；检测涉及疼痛感觉的机械刺激；和化学突触传递的调节。预测作用于信号转导的上游或内部。预测位于神经元投射；神经细胞体；和突触前膜。预计是质膜的组成部分。以多种结构表达，包括眼睛；性腺;回肠;肝脏和胆道系统；和神经系统。该基因的人类直系同源物与注意力缺陷多动障碍有关；自闭症；和精神分裂症。与人类 GRM8（谷氨酸代谢受体 8）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables group III metabotropic glutamate receptor activity. Predicted to be involved in several processes, including adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway; detection of mechanical stimulus involved in sensory perception of pain; and modulation of chemical synaptic transmission. Predicted to act upstream of or within signal transduction. Predicted to be located in neuron projection; neuronal cell body; and presynaptic membrane. Predicted to be integral component of plasma membrane. Is expressed in several structures, including eye; gonad; ileum; liver and biliary system; and nervous system. Human ortholog(s) of this gene implicated in attention deficit hyperactivity disorder; autistic disorder; and schizophrenia. Orthologous to human GRM8 (glutamate metabotropic receptor 8). [provided by Alliance of Genome Resources, Apr 2022]