2. Gene
  3. Herc2 - HECT and RLD domain containing E3 ubiquitin protein ligase 2 Gene

Herc2 - HECT and RLD domain containing E3 ubiquitin protein ligase 2 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: rjs; jdf2; D15F32S1h; mKIAA0393; D7H15F32S1; D7H15F37S1

基因 ID: 15204 | 基因类型: protein coding

关于 Herc2

功能概要

Predicted to enable SUMO binding activity; ubiquitin protein Ligase activity; and ubiquitin protein Ligase binding activity. Involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Acts upstream of or within spermatogenesis. Located in mitochondrial inner membrane. Is expressed in several structures, including central nervous system; ganglia; and trunk. Human ortholog(s) of this gene implicated in autosomal recessive non-syndromic intellectual disability and pigmentation disease. Orthologous to human HERC2 (HECT and RLD domain containing E3 ubiquitin protein Ligase 2). [provided by Alliance of Genome Resources, Apr 2022]

Herc2 基因产物(2)

mRNA Protein Name
NM_001360080.1 NP_001347009.1 E3 ubiquitin-protein ligase HERC2
NM_010418.2 NP_034548.2 E3 ubiquitin-protein ligase HERC2
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
26355680 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within negative regulation of Notch signaling pathway IDA
IDA: 通过直接分析推断
26355680 MGI
acts upstream of or within neuron differentiation IDA
IDA: 通过直接分析推断
26355680 MGI
involved in proteasome-mediated ubiquitin-dependent protein catabolic process IMP
IMP: 通过突变表型推断
26692333 MGI
acts upstream of or within spermatogenesis IMP
IMP: 通过突变表型推断
5565073 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

E3 ubiquitin-protein ligase HERC2

HECT domain and RCC1-like domain-containing protein 2

HECT-type E3 ubiquitin transferase HERC2

hect (homologous to the E6-AP (UBE3A) carboxyl terminus) domain and RCC1 (CHC1)-like domain (RLD) 2

probable E3 ubiquitin-protein ligase HERC2

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS06127 HERC2 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS19689 Herc2 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS26183 Herc2 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Herc2 NCBI NCBI:8924
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