2. Gene
  3. Hpse - heparanase Gene

Hpse - heparanase Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Hpa; HSE1; Hpr1

基因 ID: 15442 | 基因类型: protein coding

关于 Hpse

功能概要

This gene encodes an endoglucuronidase enzyme that plays an important role in tumor invasion and metastasis. The encoded preproprotein undergoes proteolytic processing to generate an active heterodimeric enzyme that cleaves the heparan sulfate proteoglycans associated with the cell surface and extracellular matrix. Mice lacking the encoded protein do not show any prominent pathological alterations under normal conditions but fail to develop albuminuria and renal damage in response to drug-induced diabetes. [provided by RefSeq, Aug 2016]

Hpse 基因产物(1)

mRNA Protein Name
NM_152803.5 NP_690016.1 heparanase preproprotein
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables heparanase activity IDA
IDA: 通过直接分析推断
12460766 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in angiogenesis involved in wound healing IDA
IDA: 通过直接分析推断
15793281 MGI
involved in establishment of endothelial barrier IDA
IDA: 通过直接分析推断
27026367 MGI
involved in heparan sulfate proteoglycan catabolic process IDA
IDA: 通过直接分析推断
12460766 MGI
involved in heparin metabolic process IDA
IDA: 通过直接分析推断
27026367 MGI
involved in heparin metabolic process IMP
IMP: 通过突变表型推断
27026367 MGI
involved in positive regulation of hair follicle development IDA
IDA: 通过直接分析推断
15793281 MGI
involved in positive regulation of osteoblast proliferation IDA
IDA: 通过直接分析推断
18589009 MGI
involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IDA
IDA: 通过直接分析推断
17689495 MGI
involved in protein transmembrane transport IMP
IMP: 通过突变表型推断
27026367 MGI
involved in response to antibiotic IDA
IDA: 通过直接分析推断
31402170 MGI
involved in vascular wound healing IDA
IDA: 通过直接分析推断
15793281 MGI
involved in wound healing IDA
IDA: 通过直接分析推断
15793281 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in extracellular space IDA
IDA: 通过直接分析推断
27026367 MGI
located in membrane raft IDA
IDA: 通过直接分析推断
17689495 MGI
located in nucleus IDA
IDA: 通过直接分析推断
15793281 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

heparanase

endo-glucoronidase

endoglycosidase heparanase

相关产品

Pre-clinical Phase
生物活性分子 (7)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-155410 HPSE1-IN-1 / 否
HY-155411 HPSE1-IN-2 / 否
HY-RS06350 HPSE Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS06351 HPSE2 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-W342853 HPSE-IN-1 Inhibitor / 否
HY-RS17957 Hpse Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS24428 Hpse Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Hpse NCBI NCBI:10855
Rattus norvegicus Hpse NCBI NCBI:64537
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