2. Gene
  3. Hsd17b4 - hydroxysteroid (17-beta) dehydrogenase 4 Gene

Hsd17b4 - hydroxysteroid (17-beta) dehydrogenase 4 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: DBP; MFP2; MFE-2; MPF-2; Mfp-2; perMFE-2; 17[b]-HSD; 17-beta-HSD

基因 ID: 15488 | 基因类型: protein coding

关于 Hsd17b4

功能概要

Predicted to enable hydro-lyase activity; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; and protein homodimerization activity. Acts upstream of or within Sertoli cell development; fatty acid beta-oxidation; and very long-chain fatty acid metabolic process. Located in peroxisome. Is expressed in several structures, including brain; genitourinary system; hindlimb phalanx; integumental system; and jaw. Used to study D-bifunctional protein deficiency. Human ortholog(s) of this gene implicated in D-bifunctional protein deficiency; Perrault syndrome; and Stiff-Person syndrome. Orthologous to human HSD17B4 (hydroxysteroid 17-beta dehydrogenase 4). [provided by Alliance of Genome Resources, Apr 2022]

Hsd17b4 基因产物(1)

mRNA Protein Name
NM_008292.4 NP_032318.2 peroxisomal multifunctional enzyme type 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
32814053 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within Sertoli cell development IMP
IMP: 通过突变表型推断
16484321 MGI
acts upstream of or within fatty acid beta-oxidation IMP
IMP: 通过突变表型推断
17442273 MGI
acts upstream of or within very long-chain fatty acid metabolic process IMP
IMP: 通过突变表型推断
16484321 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in peroxisome IDA
IDA: 通过直接分析推断
12897163 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

peroxisomal multifunctional enzyme type 2

17-beta-HSD 4

17-beta-hydroxysteroid dehydrogenase 4

D-bifunctional protein

multifunctional protein 2

相关产品

Pre-clinical Phase
生物活性分子 (4)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-120897 NS-3-008 hydrochloride Inhibitor 99.67% 否
HY-RS06397 HSD17B4 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS20632 Hsd17b4 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS27141 Hsd17b4 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Hsd17b4 NCBI NCBI:3295
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