2. Gene
  3. Irf8 - interferon regulatory factor 8 Gene

Irf8 - interferon regulatory factor 8 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Myls; ICSBP; IRF-8; Icsbp1

基因 ID: 15900 | 基因类型: protein coding

关于 Irf8

功能概要

The protein encoded by this gene is a transcription factor that belongs to the interferon regulatory factor family. Proteins belonging to this family have a DNA binding domain at the amino terminus that contains five well-conserved tryptophan-rich repeats. This domain recognizes DNA sequences similar to the interferon-stimulated response element. The protein encoded by this gene promotes or suppresses lineage-specific genes to regulate the differentation of lymphoid and myeloid lineage cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014]

Irf8 基因产物(2)

mRNA Protein Name
NM_001301811.1 NP_001288740.1 interferon regulatory factor 8
NM_008320.4 NP_032346.1 interferon regulatory factor 8
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA binding IDA
IDA: 通过直接分析推断
18045875 MGI
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
IDA: 通过直接分析推断
25331958 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
18045875 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within cellular response to lipopolysaccharide IMP
IMP: 通过突变表型推断
9348310 MGI
acts upstream of or within defense response to bacterium IMP
IMP: 通过突变表型推断
18045875 MGI
acts upstream of or within defense response to protozoan IMP
IMP: 通过突变表型推断
9348310 MGI
involved in dendritic cell differentiation IMP
IMP: 通过突变表型推断
12461077 MGI
involved in follicular B cell differentiation IGI
IGI: 通过遗传相互作用推断
31000603 MGI
involved in germinal center B cell differentiation IGI
IGI: 通过遗传相互作用推断
31000603 MGI
acts upstream of or within immune response IMP
IMP: 通过突变表型推断
12393690 MGI
involved in immune response IMP
IMP: 通过突变表型推断
12461077 MGI
acts upstream of interleukin-12 production IMP
IMP: 通过突变表型推断
9348310 MGI
acts upstream of or within myeloid cell differentiation IMP
IMP: 通过突变表型推断
12393690 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IGI
IGI: 通过遗传相互作用推断
25331958 MGI
involved in negative regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
32741026 MGI
acts upstream of or within phagocytosis IMP
IMP: 通过突变表型推断
18045875 MGI
involved in plasmacytoid dendritic cell differentiation IMP
IMP: 通过突变表型推断
12538667 MGI
acts upstream of or within positive regulation of DNA-templated transcription IPI
IPI: 通过物理相互作用推断
18045875 MGI
acts upstream of or within positive regulation of interleukin-12 production IMP
IMP: 通过突变表型推断
9348310 MGI
involved in positive regulation of transcription by RNA polymerase II IGI
IGI: 通过遗传相互作用推断
31000603 MGI
acts upstream of or within positive regulation of type II interferon production IMP
IMP: 通过突变表型推断
9348310 MGI
involved in regulation of type I interferon production IMP
IMP: 通过突变表型推断
12461077 MGI
acts upstream of or within response to bacterium IMP
IMP: 通过突变表型推断
9348310 MGI
acts upstream of type II interferon production IMP
IMP: 通过突变表型推断
9348310 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in nucleus IDA
IDA: 通过直接分析推断
18045875 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

interferon regulatory factor 8

interferon consensus sequence binding protein 1

interferon consensus sequence-binding protein

相关产品

Pre-clinical Phase
生物活性分子 (4)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-175759 EN1033 99.96% 否
HY-RS06912 IRF8 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS18767 Irf8 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS25255 Irf8 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Irf8 NCBI NCBI:3394
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