2. Gene
  3. Ighm - immunoglobulin heavy constant mu Gene

Ighm - immunoglobulin heavy constant mu Gene

  • 基因
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Igm; muH; Igh6; Igh-6; Igh-M

基因 ID: 16019 | 基因类型: other

关于 Ighm

功能概要

Enables several functions, including antigen binding activity; identical protein binding activity; and immunoglobulin receptor binding activity. Acts upstream of or within several processes, including early endosome to late endosome transport; immunoglobulin mediated immune response; and positive regulation of B cell proliferation. Located in external side of plasma membrane; extracellular space; and perinuclear region of cytoplasm. Part of B cell receptor complex and immunoglobulin complex, circulating. Is expressed in several structures, including brain; hemolymphoid system; and liver. Used to study non-Hodgkin lymphoma and type 1 diabetes mellitus. Human ortholog(s) of this gene implicated in agammaglobulinemia. Orthologous to human IGHM (immunoglobulin heavy constant mu). [provided by Alliance of Genome Resources, Apr 2022]

基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables antigen binding IDA
IDA: 通过直接分析推断
7688139 MGI
enables identical protein binding IPI
IPI: 通过物理相互作用推断
24963139 MGI
enables immunoglobulin receptor binding IPI
IPI: 通过物理相互作用推断
20031218 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
1373499 MGI
enables transmembrane signaling receptor activity IDA
IDA: 通过直接分析推断
1373499 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of B cell activation IDA
IDA: 通过直接分析推断
8566034 MGI
acts upstream of or within B cell affinity maturation IMP
IMP: 通过突变表型推断
9707605 MGI
acts upstream of B cell proliferation IDA
IDA: 通过直接分析推断
8666928 MGI
acts upstream of or within B cell receptor signaling pathway IDA
IDA: 通过直接分析推断
1373499 MGI
acts upstream of MAPK cascade IDA
IDA: 通过直接分析推断
9254656 MGI
acts upstream of or within humoral immune response mediated by circulating immunoglobulin IDA
IDA: 通过直接分析推断
8041705 MGI
acts upstream of or within immunoglobulin mediated immune response IDA
IDA: 通过直接分析推断
8552190 MGI
acts upstream of peptidyl-tyrosine phosphorylation IDA
IDA: 通过直接分析推断
7499277 MGI
acts upstream of or within positive regulation of B cell activation IDA
IDA: 通过直接分析推断
8566034 MGI
acts upstream of or within positive regulation of B cell proliferation IDA
IDA: 通过直接分析推断
8552190 MGI
acts upstream of or within positive regulation of MAPK cascade IDA
IDA: 通过直接分析推断
9254656 MGI
acts upstream of or within positive regulation of immune response IMP
IMP: 通过突变表型推断
9707605 MGI
acts upstream of or within positive regulation of peptidyl-tyrosine phosphorylation IDA
IDA: 通过直接分析推断
1373499 MGI
involved in pre-B cell allelic exclusion IMP
IMP: 通过突变表型推断
1545868 MGI
acts upstream of or within regulation of cell morphogenesis IMP
IMP: 通过突变表型推断
9707605 MGI
acts upstream of or within regulation of immunoglobulin production IMP
IMP: 通过突变表型推断
9707605 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of B cell receptor complex IDA
IDA: 通过直接分析推断
1373499 MGI
located in cell surface IDA
IDA: 通过直接分析推断
9707605 MGI
is active in cytoplasm IDA
IDA: 通过直接分析推断
28923960 MGI
located in external side of plasma membrane IDA
IDA: 通过直接分析推断
1373499 MGI
located in extracellular space IDA
IDA: 通过直接分析推断
9707605 MGI
part of immunoglobulin complex, circulating IDA
IDA: 通过直接分析推断
7688139 MGI
located in membrane IDA
IDA: 通过直接分析推断
9707605 MGI
located in perinuclear region of cytoplasm IDA
IDA: 通过直接分析推断
1373499 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

相关产品

Pre-clinical Phase
生物活性分子 (4)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-174536 Human TFE3 mRNA / 否
HY-RS16457 IGHM Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS22206 Ighm Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS28728 Gcnt4 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Ighm NCBI NCBI:3507
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