2. Gene
  3. Itga5 - integrin alpha 5 (fibronectin receptor alpha) Gene

Itga5 - integrin alpha 5 (fibronectin receptor alpha) Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Fnra; VLA5; Cd49e

基因 ID: 16402 | 基因类型: protein coding

关于 Itga5

功能概要

The product of this gene belongs to the Integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes the Integrin alpha 5 chain, which is proteolytically processed to generate light and heavy chains that join with beta 1 to form a fibronectin receptor. In addition to adhesion, integrins are known to participate in cell-surface mediated signaling. Integrin alpha 5 and Integrin alpha V chains are produced by distinct genes. Homozygous knockout mice for this gene exhibit embryonic lethality. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]

Itga5 基因产物(2)

mRNA Protein Name
NM_001314041.1 NP_001300970.1 integrin alpha-5 isoform 2
NM_010577.4 NP_034707.5 integrin alpha-5 isoform 1 preproprotein
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables integrin binding IPI
IPI: 通过物理相互作用推断
8601592 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
12867986 MGI
enables signaling receptor activity IDA
IDA: 通过直接分析推断
36812915 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within cell-cell adhesion mediated by integrin IMP
IMP: 通过突变表型推断
8557754 MGI
acts upstream of or within cell-substrate junction assembly IDA
IDA: 通过直接分析推断
12867986 MGI
acts upstream of or within heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IMP
IMP: 通过突变表型推断
8557754 MGI
acts upstream of or within leukocyte cell-cell adhesion IMP
IMP: 通过突变表型推断
8557754 MGI
acts upstream of or within memory IMP
IMP: 通过突变表型推断
12904471 MGI
involved in regulation of angiogenesis IGI
IGI: 通过遗传相互作用推断
19460962 MGI
involved in response to muscle activity IDA
IDA: 通过直接分析推断
36812915 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in Golgi apparatus IDA
IDA: 通过直接分析推断
12189152 MGI
located in cell surface IDA
IDA: 通过直接分析推断
8306881 MGI
located in cytoplasmic vesicle IDA
IDA: 通过直接分析推断
12189152 MGI
located in endoplasmic reticulum IDA
IDA: 通过直接分析推断
12189152 MGI
located in external side of plasma membrane IDA
IDA: 通过直接分析推断
8557754 MGI
is active in plasma membrane IDA
IDA: 通过直接分析推断
36812915 MGI
located in plasma membrane IDA
IDA: 通过直接分析推断
12189152 MGI
located in synapse IDA
IDA: 通过直接分析推断
12904471 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

integrin alpha-5

CD49 antigen-like family member E

fibronectin receptor alpha polypeptide

fibronectin receptor subunit alpha

integrin alpha-F

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS06952 ITGA5 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS16901 Itga5 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS23343 Itga5 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Itga5 NCBI NCBI:3678
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