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  3. Lig3 - ligase III, DNA, ATP-dependent Gene

Lig3 - ligase III, DNA, ATP-dependent Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: D11Wsu78e

基因 ID: 16882 | 基因类型: protein coding

关于 Lig3

功能概要

Predicted to enable DNA Ligase (ATP) activity. Involved in double-strand break repair via alternative nonhomologous end joining and mitochondrion organization. Acts upstream of or within double-strand break repair via nonhomologous end joining; mitochondrial DNA repair; and negative regulation of DNA recombination. Located in synaptonemal complex. Is expressed in several structures, including early conceptus; gonad; hemolymphoid system gland; liver; and lung. Human ortholog(s) of this gene implicated in pancreatic Cancer. Orthologous to human LIG3 (DNA Ligase 3). [provided by Alliance of Genome Resources, Apr 2022]

Lig3 基因产物(14)

mRNA Protein Name
NM_001291245.2 NP_001278174.1 DNA ligase 3 isoform a
NM_001291246.2 NP_001278175.1 DNA ligase 3 isoform b
NM_001291247.2 NP_001278176.1 DNA ligase 3 isoform b
NM_001403856.1 NP_001390785.1 DNA ligase 3 isoform a
NM_001403857.1 NP_001390786.1 DNA ligase 3 isoform a
NM_001403858.1 NP_001390787.1 DNA ligase 3 isoform b
NM_001403859.1 NP_001390788.1 DNA ligase 3 isoform c
NM_001403860.1 NP_001390789.1 DNA ligase 3 isoform d
NM_001403861.1 NP_001390790.1 DNA ligase 3 isoform e
NM_001403862.1 NP_001390791.1 DNA ligase 3 isoform f
NM_001403863.1 NP_001390792.1 DNA ligase 3 isoform g
NM_001403864.1 NP_001390793.1 DNA ligase 3 isoform h
NM_001403865.1 NP_001390794.1 DNA ligase 3 isoform i
NM_010716.4 NP_034846.2 DNA ligase 3 isoform a
基因本体论
  • 生物过程
  • 细胞组分
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in double-strand break repair via alternative nonhomologous end joining IMP
IMP: 通过突变表型推断
21655080 MGI
acts upstream of or within double-strand break repair via nonhomologous end joining IMP
IMP: 通过突变表型推断
21655080 MGI
acts upstream of or within mitochondrial DNA repair IMP
IMP: 通过突变表型推断
21390131 MGI
involved in mitochondrion organization IMP
IMP: 通过突变表型推断
21390131 MGI
acts upstream of or within negative regulation of DNA recombination IMP
IMP: 通过突变表型推断
16648486 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in condensed nuclear chromosome IDA
IDA: 通过直接分析推断
9001252 MGI
located in synaptonemal complex IDA
IDA: 通过直接分析推断
9001252 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

DNA ligase 3

DNA ligase (ATP) 3

DNA ligase III

polydeoxyribonucleotide synthase [ATP] 3

相关产品

Pre-clinical Phase
生物活性分子 (4)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS07643 LIG3 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS07789 LRIG3 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS22220 Lig3 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS28742 Lig3 Rat Pre-designed siRNA Set A Pre-designed Set / 否
抗体抑制剂 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-P991208 Flt-3L-Ig (hum/hum) 98% 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Lig3 NCBI NCBI:3980
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