2. Gene
  3. Mgmt - O-6-methylguanine-DNA methyltransferase Gene

Mgmt - O-6-methylguanine-DNA methyltransferase Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：O-6-甲基鸟嘌呤-DNA 甲基转移酶

种属: Mus musculus

同用名: AGT; Agat

基因 ID: 17314 | 基因类型: protein coding

关于 Mgmt

Chromosome 7: 136,496,343-136,731,995 forward strand.GRCm39:CM001000.3

This gene has 1 transcript (splice variant), 189 orthologues and is associated with 9 phenotypes. Ubiquitous expression in liver adult (RPKM 5.7), subcutaneous fat pad adult (RPKM 5.) and 24 other tissues.

功能概要

该基因编码的蛋白可启动甲基转移酶活性。作用于 DNA 脱烷基化的上游或内部，参与 DNA 修复和参与细胞凋亡过程的半胱氨酸型内肽酶活性的调节。预测位于核质中。预计活跃于核心。在胚胎和前肢芽中表达。该基因的人类直系同源物与多种疾病有关，包括癌（多种）；内分泌腺癌（多发）；颗粒细胞瘤；神经系统癌症（多发性）；和膀胱癌。与人类 MGMT（O-6-甲基鸟嘌呤-DNA 甲基转移酶）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables methyltransferase activity. Acts upstream of or within DNA dealkylation involved in DNA repair and regulation of cysteine-type endopeptidase activity involved in apoptotic process. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Is expressed in embryo and forelimb bud. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); endocrine gland Cancer (multiple); granulosa cell tumor; nervous system Cancer (multiple); and urinary bladder Cancer. Orthologous to human MGMT (O-6-methylguanine-DNA methyltransferase). [provided by Alliance of Genome Resources, Apr 2022]

Mgmt 基因产物(10)

mRNA Protein Name
NM_001412701.1 NP_001399630.1 methylated-DNA--protein-cysteine methyltransferase isoform 4
NM_001412704.1 NP_001399633.1 methylated-DNA--protein-cysteine methyltransferase isoform 1
NM_001412703.1 NP_001399632.1 methylated-DNA--protein-cysteine methyltransferase isoform 5
NM_001412698.1 NP_001399627.1 methylated-DNA--protein-cysteine methyltransferase isoform 3
NM_001412702.1 NP_001399631.1 methylated-DNA--protein-cysteine methyltransferase isoform 4
NM_001377037.2 NP_001363966.1 methylated-DNA--protein-cysteine methyltransferase isoform 1
NM_001412697.1 NP_001399626.1 methylated-DNA--protein-cysteine methyltransferase isoform 2
NM_008598.4 NP_032624.1 methylated-DNA--protein-cysteine methyltransferase isoform 1
NM_001412699.1 NP_001399628.1 methylated-DNA--protein-cysteine methyltransferase isoform 3
NM_001412700.1 NP_001399629.1 methylated-DNA--protein-cysteine methyltransferase isoform 3
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables methyltransferase activity IDA
IDA: 通过直接分析推断
1554415 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within DNA alkylation repair IDA
IDA: 通过直接分析推断
1554415 MGI
acts upstream of or within DNA damage response IMP
IMP: 通过突变表型推断
9560238 MGI
acts upstream of or within DNA repair IMP
IMP: 通过突变表型推断
13679151 MGI
acts upstream of or within regulation of cysteine-type endopeptidase activity involved in apoptotic process IMP
IMP: 通过突变表型推断
13679151 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Mgmt 蛋白结构

AdaB

AdaB: COG0350 (5 - 177)

  • 0
  • 100
  • 211 a.a.
蛋白主名 其他名称

methylated-DNA--protein-cysteine methyltransferase

6-O-methylguanine-DNA methyltransferase

O-6-alkylguanine-DNA alkyltransferase

O-6-methylguanine-DNA-alkyltransferase

相关产品

Clinical Phase
生物活性分子 (1)
目录号 产品名 作用方式
纯度 Phase
HY-13668 Lomeguatrib Inhibitor 99.77% Phase 2
Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-13057 O6BTG-octylglucoside Inhibitor 95.0% 否
HY-180540 MGMT-IN-1 Inhibitor / 否
HY-175299 Hedgehog IN-11 Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Mgmt NCBI NCBI:4255
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