2. Gene
  3. Notch2 - notch 2 Gene

Notch2 - notch 2 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: N2

基因 ID: 18129 | 基因类型: protein coding

关于 Notch2

功能概要

Enables NF-kappaB binding activity and enzyme binding activity. Involved in several processes, including heart looping; left/right axis specification; and marginal zone B cell differentiation. Acts upstream of or within several processes, including animal organ development; cholangiocyte proliferation; and positive regulation of BMP signaling pathway. Located in cilium and nucleus. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; genitourinary system; and sensory organ. Used to study Hajdu-Cheney syndrome and pre-eclampsia. Human ortholog(s) of this gene implicated in Alagille syndrome and Hajdu-Cheney syndrome. Orthologous to human NOTCH2 (Notch receptor 2). [provided by Alliance of Genome Resources, Apr 2022]

Notch2 基因产物(1)

mRNA Protein Name
NM_010928.2 NP_035058.2 neurogenic locus notch homolog protein 2 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables NF-kappaB binding IPI
IPI: 通过物理相互作用推断
18710934 MGI
enables enzyme binding IPI
IPI: 通过物理相互作用推断
17573339 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
9111338 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of BMP signaling pathway IMP
IMP: 通过突变表型推断
23676271 MGI
acts upstream of or within Notch signaling pathway IDA
IDA: 通过直接分析推断
34635817 MGI
acts upstream of or within activation of protein kinase B activity IDA
IDA: 通过直接分析推断
34635817 MGI
acts upstream of cell population proliferation IMP
IMP: 通过突变表型推断
23676271 MGI
acts upstream of or within cholangiocyte proliferation IMP
IMP: 通过突变表型推断
25446530 MGI
acts upstream of or within ciliary body morphogenesis IMP
IMP: 通过突变表型推断
23676271 MGI
acts upstream of or within defense response to bacterium IMP
IMP: 通过突变表型推断
23913046 MGI
acts upstream of or within determination of left/right symmetry IMP
IMP: 通过突变表型推断
12730124 MGI
acts upstream of or within embryonic limb morphogenesis IGI
IGI: 通过遗传相互作用推断
16169548 MGI
involved in glomerular capillary formation IEP
IEP: 通过表达模式推断
15821257 MGI
involved in heart looping IGI
IGI: 通过遗传相互作用推断
12730124 MGI
acts upstream of or within hepatocyte proliferation IMP
IMP: 通过突变表型推断
25446530 MGI
acts upstream of or within humoral immune response IGI
IGI: 通过遗传相互作用推断
17658279 MGI
acts upstream of or within in utero embryonic development IMP
IMP: 通过突变表型推断
17359302 MGI
acts upstream of or within inflammatory response to antigenic stimulus IGI
IGI: 通过遗传相互作用推断
17658279 MGI
acts upstream of or within interleukin-4 production IGI
IGI: 通过遗传相互作用推断
17658279 MGI
acts upstream of or within intrahepatic bile duct development IMP
IMP: 通过突变表型推断
25446530 MGI
involved in left/right axis specification IGI
IGI: 通过遗传相互作用推断
12730124 MGI
acts upstream of or within liver development IMP
IMP: 通过突变表型推断
25446530 MGI
acts upstream of or within liver morphogenesis IMP
IMP: 通过突变表型推断
25446530 MGI
involved in marginal zone B cell differentiation IMP
IMP: 通过突变表型推断
19217325 MGI
acts upstream of or within morphogenesis of an epithelial sheet IMP
IMP: 通过突变表型推断
11861489 MGI
acts upstream of or within multicellular organism growth IMP
IMP: 通过突变表型推断
25446530 MGI
acts upstream of or within myeloid dendritic cell differentiation IMP
IMP: 通过突变表型推断
23913046 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
23676271 MGI
acts upstream of or within placenta blood vessel development IMP
IMP: 通过突变表型推断
17359302 MGI
acts upstream of or within placenta development IMP
IMP: 通过突变表型推断
17359302 MGI
involved in podocyte development IEP
IEP: 通过表达模式推断
15821257 MGI
acts upstream of or within positive regulation of BMP signaling pathway IMP
IMP: 通过突变表型推断
23676271 MGI
acts upstream of or within positive regulation of apoptotic process IGI
IGI: 通过遗传相互作用推断
16169548 MGI
acts upstream of or within positive regulation of cell population proliferation IMP
IMP: 通过突变表型推断
23676271 MGI
involved in positive regulation of osteoclast differentiation IDA
IDA: 通过直接分析推断
18710934 MGI
involved in proximal tubule development IEP
IEP: 通过表达模式推断
15821257 MGI
acts upstream of or within regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
25446530 MGI
involved in wound healing IDA
IDA: 通过直接分析推断
12496659 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cilium IDA
IDA: 通过直接分析推断
21703454 MGI
located in nucleus IDA
IDA: 通过直接分析推断
12496659 MGI
located in plasma membrane IDA
IDA: 通过直接分析推断
34635817 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

neurogenic locus notch homolog protein 2

Motch B

Notch gene homolog 2

相关产品

Clinical Phase
生物活性分子 (1)
目录号 产品名 作用方式
纯度 Phase
HY-15670 BMS-906024 Inhibitor 99.91% Phase 1
抗体抑制剂 (1)
目录号 产品名 作用方式
纯度 Phase
HY-P99320 Tarextumab Inhibitor 99.83% Phase 2
Pre-clinical Phase
生物活性分子 (6)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-N6727 Gliotoxin 99.51% 否
HY-RS09448 NOTCH2 Human Pre-designed siRNA Set A / 否
HY-RS09450 NOTCH2NLC Human Pre-designed siRNA Set A / 否
HY-RS09449 NOTCH2NLA Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS19796 Notch2 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS26292 Notch2 Rat Pre-designed siRNA Set A Pre-designed Set / 否
抗体抑制剂 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-P990206 Anti-Mouse Jagged 2 Antibody (HMJ2-1) Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Notch2 NCBI NCBI:4853
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