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  2. Npy2r - neuropeptide Y receptor Y2 Gene

Npy2r - neuropeptide Y receptor Y2 Gene

中文名称:神经肽 Y 受体 Y2

种属: Mus musculus

同用名: NPY2-R

基因 ID: 18167 | 基因类型: protein coding

关于 Npy2r

Chromosome 3: 82,445,690-82,455,391 reverse strand.GRCm39:CM000996.3

This gene has 4 transcripts (splice variants), 248 orthologues, 55 paralogues and is associated with 40 phenotypes. Biased expression in adrenal adult (RPKM 1.5), genital fat pad adult (RPKM 1.1) and 11 other tissues.

功能概要

该基因编码的蛋白可启动肽 YY 受体活性。作用于腺苷酸环化酶抑制 G 蛋白偶联受体信号通路的上游或内部。位于非运动纤毛中。在中枢神经系统中表达;背根神经节;眼睛;和后肾。该基因的人类直系同源物与亨廷顿病有关;病态肥胖;和肥胖。与人 NPY2R(神经肽 Y 受体 Y2)同源。 [由基因组资源联盟提供,2022 年 4 月]

Enables peptide YY receptor activity. Acts upstream of or within adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway. Located in non-motile cilium. Is expressed in central nervous system; dorsal root ganglion; eye; and metanephros. Human ortholog(s) of this gene implicated in Huntington's disease; morbid obesity; and obesity. Orthologous to human NPY2R (Neuropeptide Y Receptor Y2). [provided by Alliance of Genome Resources, Apr 2022]

Npy2r 基因产物(5)

mRNA Protein Name
NM_001410444.1 NP_001397373.1 neuropeptide Y receptor type 2 isoform 1
NM_001410445.1 NP_001397374.1 neuropeptide Y receptor type 2 isoform 1
NM_008731.4 NP_032757.2 neuropeptide Y receptor type 2 isoform 1
NM_001205099.2 NP_001192028.1 neuropeptide Y receptor type 2 isoform 2
NM_001410443.1 NP_001397372.1 neuropeptide Y receptor type 2 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables neuropeptide Y receptor activity IDA
IDA: 通过直接分析推断
10698177 MGI
enables peptide YY receptor activity IDA
IDA: 通过直接分析推断
10698177 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within G protein-coupled receptor signaling pathway IMP
IMP: 通过突变表型推断
24316073 MGI
acts upstream of or within adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway IDA
IDA: 通过直接分析推断
24316073 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in cilium IDA
IDA: 通过直接分析推断
26053317 MGI
located in non-motile cilium IDA
IDA: 通过直接分析推断
24316073 MGI
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

Npy2r 蛋白结构

7tmA_NPY2R

7tmA_NPY2R: cd15399 (50 - 335)

7tmA_NPY2R

7tmA_NPY2R: cd15399 (51 - 77)

7tmA_NPY2R

7tmA_NPY2R: cd15399 (84 - 109)

7tmA_NPY2R

7tmA_NPY2R: cd15399 (122 - 152)

7tmA_NPY2R

7tmA_NPY2R: cd15399 (163 - 184)

7tmA_NPY2R

7tmA_NPY2R: cd15399 (215 - 244)

7tmA_NPY2R

7tmA_NPY2R: cd15399 (260 - 290)

7tmA_NPY2R

7tmA_NPY2R: cd15399 (303 - 328)

  • 0
  • 100
  • 200
  • 300
  • 381 a.a.
蛋白主名 其他名称

neuropeptide Y receptor type 2

NPY-Y2 receptor

Y2 receptor

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Npy2r NCBI NCBI:4887