2. Gene
  3. Per1 - period circadian clock 1 Gene

Per1 - period circadian clock 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Per; Hftm; mPer1; m-rigui

基因 ID: 18626 | 基因类型: protein coding

关于 Per1

功能概要

This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. This gene is upregulated by Clock/Arntl heterodimers but then represses this upregulation in a feedback loop using Per/Cry heterodimers to interact with Clock/Arntl. Polymorphisms in this gene may increase the risk of getting certain cancers. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jan 2014]

Per1 基因产物(2)

mRNA Protein Name
NM_001159367.2 NP_001152839.1 period circadian protein homolog 1
NM_011065.5 NP_035195.2 period circadian protein homolog 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA-binding transcription factor binding IPI
IPI: 通过物理相互作用推断
24154698 MGI
enables chromatin DNA binding IDA
IDA: 通过直接分析推断
24610784 MGI
enables kinase binding IPI
IPI: 通过物理相互作用推断
14701732 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
9856465 MGI
enables transcription cis-regulatory region binding IDA
IDA: 通过直接分析推断
24413057 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in chromatin remodeling IMP
IMP: 通过突变表型推断
21680841 MGI
involved in circadian regulation of gene expression IDA
IDA: 通过直接分析推断
20159955 MGI
involved in circadian regulation of gene expression IMP
IMP: 通过突变表型推断
15888647 MGI
involved in circadian rhythm IEP
IEP: 通过表达模式推断
14645221 MGI
involved in entrainment of circadian clock by photoperiod IMP
IMP: 通过突变表型推断
15888647 MGI
involved in negative regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
9856465 MGI
involved in negative regulation of glucocorticoid receptor signaling pathway IMP
IMP: 通过突变表型推断
24378737 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
9989497 MGI
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
12397359 MGI
involved in negative regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
24610784 MGI
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
24610784 MGI
involved in post-transcriptional regulation of gene expression IMP
IMP: 通过突变表型推断
15888647 MGI
involved in regulation of circadian rhythm IMP
IMP: 通过突变表型推断
11395012 MGI
involved in regulation of sodium ion transport IMP
IMP: 通过突变表型推断
24610784 MGI
involved in response to cAMP IDA
IDA: 通过直接分析推断
23443664 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in nucleus IDA
IDA: 通过直接分析推断
11591712 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

period circadian protein homolog 1

circadian clock protein PERIOD 1

circadian pacemaker protein Rigui

period homolog 1

相关产品

Pre-clinical Phase
生物活性分子 (5)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-125145 AA92593 99.94% 否
HY-N10987 Spiranthesol / 否
HY-RS10331 PER1 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS19930 Per1 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS26432 Per1 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Per1 NCBI NCBI:5187
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