2. Gene
  3. Prf1 - perforin 1 (pore forming protein) Gene

Prf1 - perforin 1 (pore forming protein) Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Pfn; Pfp; Prf-1

基因 ID: 18646 | 基因类型: protein coding

关于 Prf1

功能概要

Enables calcium ion binding activity and wide pore channel activity. Involved in several processes, including defense response to tumor cell; immune response to tumor cell; and protein homooligomerization. Acts upstream of or within T cell mediated cytotoxicity. Located in cytolytic granule and cytoplasmic vesicle. Is integral component of membrane. Is expressed in ductus deferens; epididymis; skin; and spleen. Used to study familial hemophagocytic lymphohistiocytosis 2; multiple sclerosis; and type 1 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including Crohn's disease; familial hemophagocytic lymphohistiocytosis 2; human immunodeficiency virus infectious disease; multiple sclerosis; and non-Langerhans-cell histiocytosis. Orthologous to human PRF1 (perforin 1). [provided by Alliance of Genome Resources, Apr 2022]

Prf1 基因产物(1)

mRNA Protein Name
NM_011073.3 NP_035203.3 perforin-1 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables calcium ion binding IDA
IDA: 通过直接分析推断
21037563 MGI
enables wide pore channel activity IDA
IDA: 通过直接分析推断
21037563 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within T cell mediated cytotoxicity IDA
IDA: 通过直接分析推断
15454490 MGI
involved in T cell mediated cytotoxicity IDA
IDA: 通过直接分析推断
21037563 MGI
involved in T cell mediated cytotoxicity IMP
IMP: 通过突变表型推断
7972104 MGI
involved in defense response to tumor cell IMP
IMP: 通过突变表型推断
8164737 MGI
involved in defense response to virus IMP
IMP: 通过突变表型推断
8164737 MGI
involved in granzyme-mediated programmed cell death signaling pathway IDA
IDA: 通过直接分析推断
35705808 MGI
involved in immune response to tumor cell IMP
IMP: 通过突变表型推断
8164737 MGI
involved in protein homooligomerization IDA
IDA: 通过直接分析推断
21037563 MGI
involved in protein import IDA
IDA: 通过直接分析推断
21037563 MGI
involved in protein secretion IDA
IDA: 通过直接分析推断
35705808 MGI
involved in protein transmembrane transport IDA
IDA: 通过直接分析推断
21037563 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytolytic granule IDA
IDA: 通过直接分析推断
8164737 MGI
located in cytoplasmic vesicle IDA
IDA: 通过直接分析推断
11856751 MGI
is active in immunological synapse IDA
IDA: 通过直接分析推断
8164737 MGI
is active in membrane IDA
IDA: 通过直接分析推断
21037563 MGI
located in membrane IDA
IDA: 通过直接分析推断
21037563 MGI
is active in plasma membrane IDA
IDA: 通过直接分析推断
35705808 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

perforin-1

P1

cytolysin

lymphocyte pore-forming protein

pore forming protein

相关产品

Pre-clinical Phase
生物活性分子 (4)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS11087 PRF1 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS16136 ZNF395 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS19938 Prf1 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS26440 Prf1 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Prf1 NCBI NCBI:5551
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