2. Gene
  3. Ptch1 - patched 1 Gene

Ptch1 - patched 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Ptc; mes; wig; Ptc1; Ptch; A230106A15Rik

基因 ID: 19206 | 基因类型: protein coding

关于 Ptch1

功能概要

Enables cyclin binding activity; heparin binding activity; and patched binding activity. Involved in several processes, including chordate embryonic development; negative regulation of smoothened signaling pathway; and regulation of transcription, DNA-templated. Acts upstream of or within several processes, including animal organ development; chordate embryonic development; and limb morphogenesis. Located in cilium; midbody; and plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; limb; and urinary system. Used to study basal cell carcinoma; medulloblastoma; and nevoid basal cell carcinoma syndrome. Human ortholog(s) of this gene implicated in basal cell carcinoma; holoprosencephaly; holoprosencephaly 7; and nevoid basal cell carcinoma syndrome. Orthologous to human PTCH1 (patched 1). [provided by Alliance of Genome Resources, Apr 2022]

Ptch1 基因产物(2)

mRNA Protein Name
NM_001328514.1 NP_001315443.1 protein patched homolog 1 isoform b
NM_008957.3 NP_032983.1 protein patched homolog 1 isoform a
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables cyclin binding IPI
IPI: 通过物理相互作用推断
11331587 MGI
enables heparin binding IDA
IDA: 通过直接分析推断
10500113 MGI
enables patched binding IDA
IDA: 通过直接分析推断
10500113 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
10500113 MGI
enables protein-containing complex binding IDA
IDA: 通过直接分析推断
11331587 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within animal organ morphogenesis IMP
IMP: 通过突变表型推断
12917290 MGI
involved in brain development IMP
IMP: 通过突变表型推断
11517919 MGI
acts upstream of or within branching involved in ureteric bud morphogenesis IMP
IMP: 通过突变表型推断
19809516 MGI
acts upstream of or within cell differentiation involved in kidney development IGI
IGI: 通过遗传相互作用推断
19809516 MGI
acts upstream of or within cell fate determination IGI
IGI: 通过遗传相互作用推断
24492243 MGI
acts upstream of or within cell proliferation involved in metanephros development IMP
IMP: 通过突变表型推断
19809516 MGI
involved in cellular response to cholesterol IEP
IEP: 通过表达模式推断
21931618 MGI
acts upstream of or within dorsal/ventral neural tube patterning IMP
IMP: 通过突变表型推断
9262482 MGI
acts upstream of or within dorsal/ventral pattern formation IGI
IGI: 通过遗传相互作用推断
15576403 MGI
acts upstream of or within embryonic limb morphogenesis IGI
IGI: 通过遗传相互作用推断
11389830 MGI
acts upstream of or within embryonic limb morphogenesis IMP
IMP: 通过突变表型推断
11784021 MGI
acts upstream of or within embryonic organ development IGI
IGI: 通过遗传相互作用推断
24302887 MGI
acts upstream of or within epidermal cell fate specification IGI
IGI: 通过遗传相互作用推断
24492243 MGI
acts upstream of or within epidermis development IMP
IMP: 通过突变表型推断
17631878 MGI
acts upstream of epithelial cell proliferation IMP
IMP: 通过突变表型推断
17631878 MGI
acts upstream of or within glucose homeostasis IMP
IMP: 通过突变表型推断
11044404 MGI
acts upstream of or within heart morphogenesis IMP
IMP: 通过突变表型推断
9262482 MGI
acts upstream of or within hindlimb morphogenesis IMP
IMP: 通过突变表型推断
9262482 MGI
acts upstream of or within in utero embryonic development IGI
IGI: 通过遗传相互作用推断
21406566 MGI
acts upstream of keratinocyte proliferation IMP
IMP: 通过突变表型推断
17631878 MGI
acts upstream of or within keratinocyte proliferation IMP
IMP: 通过突变表型推断
17631878 MGI
acts upstream of or within mammary gland development IMP
IMP: 通过突变表型推断
10529434 MGI
acts upstream of or within mammary gland duct morphogenesis IMP
IMP: 通过突变表型推断
10529434 MGI
acts upstream of or within mammary gland epithelial cell differentiation IMP
IMP: 通过突变表型推断
10529434 MGI
involved in negative regulation of DNA-templated transcription IMP
IMP: 通过突变表型推断
24548465 MGI
involved in negative regulation of cell division IMP
IMP: 通过突变表型推断
11331587 MGI
acts upstream of or within negative regulation of cell population proliferation IMP
IMP: 通过突变表型推断
16489008 MGI
involved in negative regulation of cell population proliferation IMP
IMP: 通过突变表型推断
11331587 MGI
acts upstream of or within negative regulation of epithelial cell proliferation IMP
IMP: 通过突变表型推断
17631878 MGI
acts upstream of or within negative regulation of keratinocyte proliferation IMP
IMP: 通过突变表型推断
17631878 MGI
acts upstream of or within negative regulation of multicellular organism growth IMP
IMP: 通过突变表型推断
11784021 MGI
acts upstream of or within negative regulation of smoothened signaling pathway IDA
IDA: 通过直接分析推断
9006067 MGI
acts upstream of or within negative regulation of smoothened signaling pathway IGI
IGI: 通过遗传相互作用推断
19004860 MGI
involved in negative regulation of smoothened signaling pathway IGI
IGI: 通过遗传相互作用推断
21931618 MGI
acts upstream of or within negative regulation of smoothened signaling pathway IMP
IMP: 通过突变表型推断
11784021 MGI
acts upstream of or within negative regulation of stem cell proliferation IMP
IMP: 通过突变表型推断
17631878 MGI
involved in neural plate axis specification IMP
IMP: 通过突变表型推断
11517919 MGI
acts upstream of or within neural tube closure IMP
IMP: 通过突变表型推断
9262482 MGI
involved in neural tube formation IDA
IDA: 通过直接分析推断
10500113 MGI
acts upstream of or within pattern specification process IMP
IMP: 通过突变表型推断
9262482 MGI
involved in positive regulation of DNA-templated transcription IMP
IMP: 通过突变表型推断
24548465 MGI
acts upstream of or within positive regulation of epidermal cell differentiation IGI
IGI: 通过遗传相互作用推断
24492243 MGI
acts upstream of or within protein processing IMP
IMP: 通过突变表型推断
16061793 MGI
acts upstream of or within regulation of cell population proliferation IMP
IMP: 通过突变表型推断
19809516 MGI
acts upstream of or within regulation of growth IMP
IMP: 通过突变表型推断
9262482 MGI
acts upstream of or within regulation of mitotic cell cycle IMP
IMP: 通过突变表型推断
16489008 MGI
involved in regulation of protein localization IDA
IDA: 通过直接分析推断
11331587 MGI
acts upstream of or within regulation of protein localization IMP
IMP: 通过突变表型推断
16489008 MGI
acts upstream of or within response to chlorate IDA
IDA: 通过直接分析推断
11476578 MGI
involved in signal transduction IDA
IDA: 通过直接分析推断
10500113 MGI
involved in somite development IMP
IMP: 通过突变表型推断
11517919 MGI
acts upstream of or within spinal cord motor neuron differentiation IGI
IGI: 通过遗传相互作用推断
21552265 MGI
acts upstream of stem cell proliferation IMP
IMP: 通过突变表型推断
17631878 MGI
acts upstream of or within stem cell proliferation IMP
IMP: 通过突变表型推断
17631878 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cilium IDA
IDA: 通过直接分析推断
19654211 MGI
located in midbody IDA
IDA: 通过直接分析推断
15166316 MGI
located in plasma membrane IDA
IDA: 通过直接分析推断
11331587 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

protein patched homolog 1

Ptch1 protein +12b

mesenchymal dysplasia

patched homolog 1

相关产品

Pre-clinical Phase
生物活性分子 (7)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-W019996 Triparanol 99.9% 否
HY-P10875 HL2-m5 Inhibitor 98.06% 否
HY-137567 Prostaglandin E1 ethanolamide Activator / 否
HY-153499 SMO-IN-4 Antagonist / 否
HY-RS11356 PTCH1 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS18678 Ptch1 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS25164 Ptch1 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Ptch1 NCBI NCBI:5727
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