2. Gene
  3. Smpd1 - sphingomyelin phosphodiesterase 1, acid lysosomal Gene

Smpd1 - sphingomyelin phosphodiesterase 1, acid lysosomal Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: ASM; aSMase; A-SMase; Zn-SMase

基因 ID: 20597 | 基因类型: protein coding

关于 Smpd1

功能概要

Enables acid sphingomyelin phosphodiesterase activity and zinc ion binding activity. Involved in ceramide biosynthetic process; positive regulation of apoptotic process; and response to ionizing radiation. Acts upstream of or within ceramide metabolic process; Cholesterol metabolic process; and sphingomyelin catabolic process. Located in extracellular space. Is expressed in several structures, including alimentary system; integumental system; nervous system; sensory organ; and skeleton. Used to study Niemann-Pick disease. Human ortholog(s) of this gene implicated in Niemann-Pick disease; Niemann-Pick disease type A; and Niemann-Pick disease type B. Orthologous to human SMPD1 (sphingomyelin phosphodiesterase 1). [provided by Alliance of Genome Resources, Apr 2022]

Smpd1 基因产物(2)

mRNA Protein Name
NM_011421.2 NP_035551.1 sphingomyelin phosphodiesterase precursor
NM_011421.2 NP_035551.1 sphingomyelin phosphodiesterase precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables acid sphingomyelin phosphodiesterase activity IDA
IDA: 通过直接分析推断
8702487 MGI
enables zinc ion binding IDA
IDA: 通过直接分析推断
8702487 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in ceramide biosynthetic process IDA
IDA: 通过直接分析推断
35705808 MGI
involved in ceramide biosynthetic process IMP
IMP: 通过突变表型推断
8706124 MGI
acts upstream of or within ceramide metabolic process IMP
IMP: 通过突变表型推断
23046545 MGI
acts upstream of or within cholesterol metabolic process IMP
IMP: 通过突变表型推断
22383528 MGI
involved in plasma membrane repair IDA
IDA: 通过直接分析推断
35705808 MGI
involved in positive regulation of apoptotic process IMP
IMP: 通过突变表型推断
8706124 MGI
involved in response to ionizing radiation IMP
IMP: 通过突变表型推断
8706124 MGI
acts upstream of or within sphingomyelin catabolic process IMP
IMP: 通过突变表型推断
23973266 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in extracellular space IDA
IDA: 通过直接分析推断
35705808 MGI
located in extracellular space IDA
IDA: 通过直接分析推断
8702487 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

sphingomyelin phosphodiesterase

acid sphingomyelinase

重组 Smpd1 蛋白

目录号 产品名 蛋白编号 纯度
HY-P76134 SMPD1 Protein, Mouse (sf9, His) Q04519 (L45-L626) ≥ 85%, as determined by reducing SDS-PAGE.

相关产品

Pre-clinical Phase
生物活性分子 (4)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS17994 Smpd1 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-134505 Avicin G Inhibitor / 否
HY-RS13447 SMPD1 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS24465 Smpd1 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Smpd1 NCBI NCBI:6609
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