1. Gene
  2. Stat5a - signal transducer and activator of transcription 5A Gene

Stat5a - signal transducer and activator of transcription 5A Gene

种属: Mus musculus

同用名: STAT5

基因 ID: 20850 | 基因类型: protein coding

关于 Stat5a

功能概要

Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and phosphate ion binding activity. Involved in growth hormone receptor signaling pathway via JAK-STAT and regulation of growth. Acts upstream of or within several processes, including animal organ development; positive regulation of leukocyte proliferation; and regulation of hemopoiesis. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; hemolymphoid system; and liver and biliary system. Orthologous to human STAT5A (signal transducer and activator of transcription 5A). [provided by Alliance of Genome Resources, Apr 2022]

Stat5a 基因产物(3)

mRNA Protein Name
NM_001164062.1 NP_001157534.1 signal transducer and activator of transcription 5A isoform 2
NM_001362680.1 NP_001349609.1 signal transducer and activator of transcription 5A isoform 1
NM_011488.3 NP_035618.1 signal transducer and activator of transcription 5A isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA binding IDA
IDA: 通过直接分析推断
10485657 MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: 通过直接分析推断
12393611 MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific IMP
IMP: 通过突变表型推断
12393611 MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: 通过直接分析推断
19666510 MGI
enables phosphate ion binding IDA
IDA: 通过直接分析推断
8702683 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
8702683 MGI
enables sequence-specific DNA binding IDA
IDA: 通过直接分析推断
12393611 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of B cell differentiation IGI
IGI: 通过遗传相互作用推断
10979977 MGI
acts upstream of or within Peyer's patch development IGI
IGI: 通过遗传相互作用推断
15294943 MGI
acts upstream of or within T cell differentiation in thymus IGI
IGI: 通过遗传相互作用推断
15294943 MGI
acts upstream of or within T cell homeostasis IGI
IGI: 通过遗传相互作用推断
10072077 MGI
acts upstream of T cell proliferation IMP
IMP: 通过突变表型推断
15947484 MGI
acts upstream of activated T cell proliferation IDA
IDA: 通过直接分析推断
10072077 MGI
acts upstream of activated T cell proliferation IGI
IGI: 通过遗传相互作用推断
10072077 MGI
acts upstream of cell population proliferation IDA
IDA: 通过直接分析推断
10652277 MGI
acts upstream of cell population proliferation IGI
IGI: 通过遗传相互作用推断
10652277 MGI
acts upstream of or within cell surface receptor signaling pathway via JAK-STAT IDA
IDA: 通过直接分析推断
10485657 MGI
acts upstream of or within cellular response to granulocyte macrophage colony-stimulating factor stimulus IDA
IDA: 通过直接分析推断
23610142 MGI
acts upstream of or within cytokine-mediated signaling pathway IDA
IDA: 通过直接分析推断
10485657 MGI
acts upstream of or within development of secondary female sexual characteristics IMP
IMP: 通过突变表型推断
9630227 MGI
acts upstream of or within development of secondary male sexual characteristics IGI
IGI: 通过遗传相互作用推断
9630227 MGI
acts upstream of or within development of secondary male sexual characteristics IMP
IMP: 通过突变表型推断
9630227 MGI
acts upstream of or within epithelial cell differentiation involved in prostate gland development IMP
IMP: 通过突变表型推断
10908145 MGI
acts upstream of erythrocyte differentiation IGI
IGI: 通过遗传相互作用推断
10072077 MGI
acts upstream of or within female pregnancy IGI
IGI: 通过遗传相互作用推断
15471942 MGI
acts upstream of gamma-delta T cell differentiation IGI
IGI: 通过遗传相互作用推断
15294943 MGI
involved in growth hormone receptor signaling pathway via JAK-STAT IDA
IDA: 通过直接分析推断
8702683 MGI
acts upstream of interleukin-2 production IGI
IGI: 通过遗传相互作用推断
10072077 MGI
acts upstream of or within lactation IMP
IMP: 通过突变表型推断
9630227 MGI
acts upstream of or within lipid storage IGI
IGI: 通过遗传相互作用推断
9630227 MGI
acts upstream of or within luteinization IGI
IGI: 通过遗传相互作用推断
9630227 MGI
acts upstream of lymphocyte differentiation IGI
IGI: 通过遗传相互作用推断
15294943 MGI
acts upstream of or within mammary gland development IMP
IMP: 通过突变表型推断
9630227 MGI
acts upstream of or within mammary gland epithelium development IGI
IGI: 通过遗传相互作用推断
12040017 MGI
acts upstream of or within mammary gland epithelium development IMP
IMP: 通过突变表型推断
12040017 MGI
acts upstream of mast cell apoptotic process IMP
IMP: 通过突变表型推断
15947484 MGI
acts upstream of mast cell differentiation IMP
IMP: 通过突变表型推断
15947484 MGI
acts upstream of mast cell proliferation IMP
IMP: 通过突变表型推断
15947484 MGI
acts upstream of mitotic cell cycle IGI
IGI: 通过遗传相互作用推断
10072077 MGI
acts upstream of myeloid cell apoptotic process IGI
IGI: 通过遗传相互作用推断
10652277 MGI
acts upstream of or within natural killer cell differentiation IGI
IGI: 通过遗传相互作用推断
10072077 MGI
acts upstream of natural killer cell differentiation IMP
IMP: 通过突变表型推断
9841920 MGI
acts upstream of natural killer cell mediated cytotoxicity IMP
IMP: 通过突变表型推断
9841920 MGI
acts upstream of or within negative regulation of erythrocyte differentiation IGI
IGI: 通过遗传相互作用推断
10072077 MGI
acts upstream of or within negative regulation of mast cell apoptotic process IMP
IMP: 通过突变表型推断
15947484 MGI
acts upstream of or within negative regulation of myeloid cell apoptotic process IGI
IGI: 通过遗传相互作用推断
10652277 MGI
acts upstream of or within peptidyl-tyrosine phosphorylation IDA
IDA: 通过直接分析推断
12388746 MGI
acts upstream of or within positive regulation of B cell differentiation IGI
IGI: 通过遗传相互作用推断
10979977 MGI
acts upstream of or within positive regulation of T cell proliferation IMP
IMP: 通过突变表型推断
15947484 MGI
acts upstream of or within positive regulation of activated T cell proliferation IDA
IDA: 通过直接分析推断
10072077 MGI
acts upstream of or within positive regulation of activated T cell proliferation IGI
IGI: 通过遗传相互作用推断
10072077 MGI
acts upstream of or within positive regulation of cell population proliferation IDA
IDA: 通过直接分析推断
10652277 MGI
acts upstream of or within positive regulation of cell population proliferation IGI
IGI: 通过遗传相互作用推断
10652277 MGI
acts upstream of or within positive regulation of gamma-delta T cell differentiation IGI
IGI: 通过遗传相互作用推断
15294943 MGI
acts upstream of or within positive regulation of inflammatory response IGI
IGI: 通过遗传相互作用推断
10652277 MGI
acts upstream of or within positive regulation of interleukin-2 production IGI
IGI: 通过遗传相互作用推断
10072077 MGI
acts upstream of or within positive regulation of lymphocyte differentiation IGI
IGI: 通过遗传相互作用推断
15294943 MGI
acts upstream of or within positive regulation of mast cell differentiation IMP
IMP: 通过突变表型推断
15947484 MGI
acts upstream of or within positive regulation of mast cell proliferation IMP
IMP: 通过突变表型推断
15947484 MGI
acts upstream of or within positive regulation of mitotic cell cycle IGI
IGI: 通过遗传相互作用推断
10072077 MGI
acts upstream of or within positive regulation of multicellular organism growth IGI
IGI: 通过遗传相互作用推断
9630227 MGI
acts upstream of or within positive regulation of natural killer cell differentiation IMP
IMP: 通过突变表型推断
9841920 MGI
acts upstream of or within positive regulation of natural killer cell mediated cytotoxicity IMP
IMP: 通过突变表型推断
9841920 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
19666510 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IGI
IGI: 通过遗传相互作用推断
10485657 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
9630227 MGI
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
12393611 MGI
acts upstream of or within prostate gland epithelium morphogenesis IMP
IMP: 通过突变表型推断
10908145 MGI
acts upstream of or within regulation of cell adhesion IMP
IMP: 通过突变表型推断
11706048 MGI
acts upstream of or within regulation of epithelial cell differentiation IMP
IMP: 通过突变表型推断
11706048 MGI
involved in regulation of multicellular organism growth IGI
IGI: 通过遗传相互作用推断
18648510 MGI
acts upstream of or within regulation of steroid metabolic process IGI
IGI: 通过遗传相互作用推断
15471942 MGI
acts upstream of or within regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
21217760 MGI
acts upstream of or within regulation of transcription by RNA polymerase II IGI
IGI: 通过遗传相互作用推断
15294943 MGI
acts upstream of or within response to peptide hormone IDA
IDA: 通过直接分析推断
12388746 MGI
acts upstream of positive effect taurine metabolic process IGI
IGI: 通过遗传相互作用推断
18648510 MGI
acts upstream of transcription by RNA polymerase II IGI
IGI: 通过遗传相互作用推断
10485657 MGI
acts upstream of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
9630227 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
11254359 MGI
located in nucleus IDA
IDA: 通过直接分析推断
12456807 MGI
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断
蛋白主名 其他名称

signal transducer and activator of transcription 5A

mammary gland factor STAT5A

Stat5a 抗体

目录号 产品名 应用 反应物种
HY-P80904A STAT5 Antibody(YA054) (PBS only) WB, ICC/IF, IP Human, Mouse, Rat

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Stat5a NCBI NCBI:6776