2. Gene
  3. Aurkb - aurora kinase B Gene

Aurkb - aurora kinase B Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：极光激酶 B

种属: Mus musculus

同用名: Aik2; Aim1; Ark2; AurB; IPL1; Stk5; AIM-1; AIRK2; STK-1; Stk12

基因 ID: 20877 | 基因类型: protein coding

关于 Aurkb

Chromosome 11: 68,936,473-68,942,490 forward strand.GRCm39:CM001004.3

This gene has 8 transcripts (splice variants), 217 orthologues, 2 paralogues and is associated with 23 phenotypes. Broad expression in thymus adult (RPKM 36.3), liver E14.5 (RPKM 33.6) and 19 other tissues.

功能概要

该基因编码丝氨酸/苏氨酸激酶的极光激酶亚家族成员。编码该亚科另外两个成员的基因位于 2 号和 7 号染色体上。这些激酶通过与微管结合参与有丝分裂和减数分裂过程中染色体排列和分离的调节。 [RefSeq 提供，2015 年 9 月]

This gene encodes a member of the Aurora Kinase subfamily of serine/threonine kinases. The genes encoding the Other two members of this subfamily are located on chromosomes 2 and 7. These kinases participate in the regulation of alignment and segregation of chromosomes during Mitosis and meiosis through association with microtubules. [provided by RefSeq, Sep 2015]

Aurkb 基因产物(1)

mRNA Protein Name
NM_011496.2 NP_035626.1 aurora kinase B
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables histone H3S28 kinase activity IDA
IDA: 通过直接分析推断
24034696 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
24034696 MGI
enables protein serine/threonine kinase activity IDA
IDA: 通过直接分析推断
29518391 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in post-translational protein modification IDA
IDA: 通过直接分析推断
24034696 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in chromocenter IDA
IDA: 通过直接分析推断
19283064 MGI
located in chromosome IDA
IDA: 通过直接分析推断
26919979 MGI
part of chromosome passenger complex IDA
IDA: 通过直接分析推断
20562830 MGI
located in chromosome, centromeric region IDA
IDA: 通过直接分析推断
26919979 MGI
located in condensed chromosome, centromeric region IDA
IDA: 通过直接分析推断
14751927 MGI
located in midbody IDA
IDA: 通过直接分析推断
9514916 MGI
located in mitotic spindle midzone IDA
IDA: 通过直接分析推断
14751927 MGI
located in mitotic spindle pole IDA
IDA: 通过直接分析推断
26919979 MGI
located in nucleus IDA
IDA: 通过直接分析推断
14751927 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Aurkb 蛋白结构

PKc_like

PKc_like: cl21453 (76 - 343)

  • 0
  • 100
  • 200
  • 300
  • 345 a.a.
蛋白主名 其他名称

aurora kinase B

ARK-2

aurora 1

aurora B

aurora- and IPL1-like midbody-associated protein 1

aurora-related kinase 2

aurora/IPL1-related kinase 2

serine/threonine kinase 12

serine/threonine kinase 5

serine/threonine-protein kinase 12

serine/threonine-protein kinase 5

serine/threonine-protein kinase aurora-B

相关产品

Clinical Phase
生物活性分子 (1)
目录号 产品名 作用方式
纯度 Phase
HY-10338A Foretinib phosphate Inhibitor / Phase 2
Pre-clinical Phase
生物活性分子 (13)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-148065 FMF-06-098-1 Inhibitor 98.77% 否
HY-151971 Aurora kinase-IN-3 Inhibitor 98.47% 否
HY-168543 PROTAC MPS1 degrader 2 Degrader 99.09% 否
HY-157480 EGFR/AURKB-IN-1 Inhibitor 99.43% 否
HY-RS01270 AURKB Human Pre-designed siRNA Set A / 否
HY-120279A CFI-400437 Inhibitor / 否
HY-123610 BRD-7880 Inhibitor / 否
HY-168540 PROTAC MPS1 degrader 1 Degrader / 否
HY-175525 MS44 Degrader / 否
HY-175526 Aurora kinase ligand-1 / 否
HY-176191 Aurora kinase-IN-7 Inhibitor / 否
HY-RS01271 Aurkb Mouse Pre-designed siRNA Set A / 否
HY-RS01272 Aurkb Rat Pre-designed siRNA Set A / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Aurkb NCBI NCBI:9212
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