2. Gene
  3. Terc - telomerase RNA component Gene

Terc - telomerase RNA component Gene

  • 基因
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: mTR; mTER

基因 ID: 21748 | 基因类型: ncRNA

关于 Terc

功能概要

Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with Reverse Transcriptase activity, and an RNA component which serves as a template for the telomere repeat. Deregulation of Telomerase expression in somatic cells may be involved in oncogenesis. Telomerase may also participate in chromosomal repair, since de novo synthesis of telomere repeats may occur at double-stranded breaks. In contrast with human Telomerase, murine Telomerase is expressed in many normal postnatal somatic tissues. [provided by RefSeq, Jul 2008]

基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables telomerase activity IMP
IMP: 通过突变表型推断
17982445 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within determination of adult lifespan IGI
IGI: 通过遗传相互作用推断
15235603 MGI
acts upstream of or within hematopoietic stem cell differentiation IMP
IMP: 通过突变表型推断
17554309 MGI
acts upstream of or within hematopoietic stem cell proliferation IMP
IMP: 通过突变表型推断
17554309 MGI
acts upstream of or within positive regulation of telomere maintenance via telomerase IMP
IMP: 通过突变表型推断
17982445 MGI
acts upstream of or within post-embryonic development IMP
IMP: 通过突变表型推断
17554309 MGI
acts upstream of or within regulation of cell population proliferation IGI
IGI: 通过遗传相互作用推断
11381263 MGI
acts upstream of or within telomere maintenance IGI
IGI: 通过遗传相互作用推断
15235603 MGI
acts upstream of or within telomere maintenance IMP
IMP: 通过突变表型推断
17145779 MGI
acts upstream of telomere maintenance via telomerase IMP
IMP: 通过突变表型推断
17982445 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

相关产品

Pre-clinical Phase
生物活性分子 (5)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-137817 BCH001 Inhibitor 98.72% 否
HY-174537 Human TERT mRNA / 否
HY-RS16330 TERC Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS17417 Terc Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS23871 Terc Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Terc NCBI NCBI:7012
Canis familiaris Terc NCBI
Macaca fascicularis Terc NCBI
Rattus norvegicus Terc NCBI NCBI:378461
Macaca mulatta Terc NCBI NCBI:100429884
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