2. Gene
  3. Gba2 - glucosidase beta 2 Gene

Gba2 - glucosidase beta 2 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: F630034E04

基因 ID: 230101 | 基因类型: protein coding

关于 Gba2

功能概要

Enables glucosylceramidase activity; glucosyltransferase activity; and steryl-beta-glucosidase activity. Involved in several processes, including glucosylceramide catabolic process; lipid glycosylation; and regulation of protein polymerization. Located in cytosol. Is extrinsic component of Golgi membrane and extrinsic component of endoplasmic reticulum membrane. Is expressed in several structures, including central nervous system; dorsal root ganglion; liver; lung; and neural retina. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 46. Orthologous to human GBA2 (glucosylceramidase beta 2). [provided by Alliance of Genome Resources, Apr 2022]

Gba2 基因产物(1)

mRNA Protein Name
NM_172692.3 NP_766280.2 non-lysosomal glucosylceramidase
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables beta-glucosidase activity IDA
IDA: 通过直接分析推断
22659419 MGI
enables beta-glucosidase activity IMP
IMP: 通过突变表型推断
22659419 MGI
enables glucosylceramidase activity IDA
IDA: 通过直接分析推断
17080196 MGI
enables glucosylceramidase activity IMP
IMP: 通过突变表型推断
22659419 MGI
enables glucosyltransferase activity IDA
IDA: 通过直接分析推断
17080196 MGI
enables steryl-beta-glucosidase activity IDA
IDA: 通过直接分析推断
26724485 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
NOT involved in bile acid metabolic process IMP
IMP: 通过突变表型推断
17080196 MGI
involved in cholesterol metabolic process IMP
IMP: 通过突变表型推断
26724485 MGI
involved in glucosylceramide catabolic process IDA
IDA: 通过直接分析推断
23250757 MGI
involved in glucosylceramide catabolic process IMP
IMP: 通过突变表型推断
17080196 MGI
involved in lipid glycosylation IDA
IDA: 通过直接分析推断
26724485 MGI
involved in regulation of actin filament polymerization IMP
IMP: 通过突变表型推断
25803043 MGI
involved in regulation of membrane lipid distribution IMP
IMP: 通过突变表型推断
25803043 MGI
involved in regulation of microtubule polymerization IMP
IMP: 通过突变表型推断
25803043 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in Golgi membrane IDA
IDA: 通过直接分析推断
23250757 MGI
located in cytosol IDA
IDA: 通过直接分析推断
23250757 MGI
located in endoplasmic reticulum membrane IDA
IDA: 通过直接分析推断
23250757 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

non-lysosomal glucosylceramidase

NLGase

beta-glucocerebrosidase 2

beta-glucosidase 2

bile acid beta-glucosidase GBA2

bile acid glucosyl transferase GBA2

cholesterol glucosyltransferase GBA2

cholesteryl-beta-glucosidase GBA2

glucosidase, beta (bile acid) 2

glucosylceramidase 2

no

相关产品

Pre-clinical Phase
生物活性分子 (5)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-129411 Sinbaglustat 99.83% 否
HY-178202 5-C-phenethyl-DNJ Inhibitor / 否
HY-RS05302 GBA2 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS18361 Gba2 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS24840 Gba2 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Gba2 NCBI NCBI:57704
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