Npr2 - natriuretic peptide receptor 2 Gene

种属: Mus musculus

同用名: cn; pwe; GC-B; GC-B2; GC-B3; mNPR-B

基因 ID: 230103 | 基因类型: protein coding

关于 Npr2

功能概要

Enables Guanylate Cyclase activity; identical protein binding activity; and natriuretic peptide receptor activity. Acts upstream of or within several processes, including bone development; negative regulation of meiotic cell cycle; and negative regulation of oocyte maturation. Predicted to be integral component of plasma membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; sensory organ; and skeleton. Used to study achondroplasia; acromesomelic dysplasia, Maroteaux type; and bone development disease. Human ortholog(s) of this gene implicated in Miura type epiphyseal chondrodysplasia; acromesomelic dysplasia, Maroteaux type; and essential hypertension. Orthologous to human NPR2 (natriuretic peptide receptor 2). [provided by Alliance of Genome Resources, Apr 2022]

Npr2 基因产物(4)

mRNA	Protein	Name
NM_001355466.1	NP_001342395.1	atrial natriuretic peptide receptor 2 isoform 2 precursor
NM_173788.4	NP_776149.1	atrial natriuretic peptide receptor 2 isoform 1 precursor
NM_001355466.1	NP_001342395.1	atrial natriuretic peptide receptor 2 isoform 2 precursor
NM_173788.4	NP_776149.1	atrial natriuretic peptide receptor 2 isoform 1 precursor

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables guanylate cyclase activity	IDA IDA: 通过直接分析推断	14514678	MGI
enables identical protein binding	IPI IPI: 通过物理相互作用推断	14514678	MGI
enables natriuretic peptide receptor activity	IDA IDA: 通过直接分析推断	14514678	MGI

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in MAPK cascade	IMP IMP: 通过突变表型推断	23065701	MGI
involved in activation of meiosis involved in egg activation	IMP IMP: 通过突变表型推断	22987720	MGI
involved in axonogenesis	IMP IMP: 通过突变表型推断	17954614	MGI
involved in axonogenesis involved in innervation	IMP IMP: 通过突变表型推断	25473838	MGI
involved in blood circulation	IMP IMP: 通过突变表型推断	32901096	MGI
involved in blood vessel development	IMP IMP: 通过突变表型推断	32901096	MGI
involved in blood vessel remodeling	IMP IMP: 通过突变表型推断	32394795	MGI
acts upstream of or within bone development	IMP IMP: 通过突变表型推断	624676	MGI
involved in bone growth	IMP IMP: 通过突变表型推断	23065701	MGI
involved in c-di-GMP signaling	IMP IMP: 通过突变表型推断	20616347	MGI
involved in cGMP metabolic process	IMP IMP: 通过突变表型推断	15722353	MGI
involved in cartilage development	IMP IMP: 通过突变表型推断	15722353	MGI
involved in cellular response to cGMP	IMP IMP: 通过突变表型推断	26522847	MGI
involved in cellular response to peptide	IMP IMP: 通过突变表型推断	28054671	MGI
involved in chemical synaptic transmission	IMP IMP: 通过突变表型推断	17954614	MGI
involved in chondrocyte differentiation	IMP IMP: 通过突变表型推断	17728275	MGI
involved in chondrocyte proliferation	IMP IMP: 通过突变表型推断	17728275	MGI
involved in chromosome organization	IMP IMP: 通过突变表型推断	22696190	MGI
involved in collateral sprouting	IMP IMP: 通过突变表型推断	17954614	MGI
involved in cumulus cell differentiation	IMP IMP: 通过突变表型推断	22696190	MGI
involved in digestive tract development	IMP IMP: 通过突变表型推断	32901096	MGI
involved in digestive tract morphogenesis	IMP IMP: 通过突变表型推断	20616347	MGI
involved in endochondral ossification	IMP IMP: 通过突变表型推断	15572448	MGI
involved in epidermal growth factor receptor signaling pathway	IMP IMP: 通过突变表型推断	22987720	MGI
involved in execution phase of apoptosis	IMP IMP: 通过突变表型推断	25012822	MGI
involved in female genitalia development	IMP IMP: 通过突变表型推断	15572448	MGI
involved in gastric emptying	IMP IMP: 通过突变表型推断	23127564	MGI
involved in genitalia morphogenesis	IMP IMP: 通过突变表型推断	25012822	MGI
involved in germ cell development	IMP IMP: 通过突变表型推断	25012822	MGI
involved in growth plate cartilage development	IMP IMP: 通过突变表型推断	17728275	MGI
involved in limb development	IMP IMP: 通过突变表型推断	15572448	MGI
involved in limb morphogenesis	IMP IMP: 通过突变表型推断	17728275	MGI
involved in lymph vessel development	IMP IMP: 通过突变表型推断	32901096	MGI
acts upstream of meiotic cell cycle	IMP IMP: 通过突变表型推断	20947764	MGI
involved in meiotic cell cycle process involved in oocyte maturation	IMP IMP: 通过突变表型推断	22696190	MGI
involved in multicellular organism growth	IMP IMP: 通过突变表型推断	15572448	MGI
involved in multicellular organismal reproductive process	IMP IMP: 通过突变表型推断	23065701	MGI
acts upstream of or within negative regulation of meiotic cell cycle	IMP IMP: 通过突变表型推断	20947764	MGI
acts upstream of or within negative regulation of oocyte maturation	IMP IMP: 通过突变表型推断	20947764	MGI
involved in nerve development	IMP IMP: 通过突变表型推断	32901096	MGI
involved in neuron apoptotic process	IMP IMP: 通过突变表型推断	29501420	MGI
involved in neuronal action potential	IMP IMP: 通过突变表型推断	25473838	MGI
involved in oocyte development	IMP IMP: 通过突变表型推断	22696190	MGI
involved in ovarian follicle development	IMP IMP: 通过突变表型推断	22696190	MGI
involved in post-anal tail morphogenesis	IMP IMP: 通过突变表型推断	17728275	MGI
involved in renal system development	IMP IMP: 通过突变表型推断	31220449	MGI
acts upstream of or within reproductive process	IMP IMP: 通过突变表型推断	20947764	MGI
involved in response to fibroblast growth factor	IMP IMP: 通过突变表型推断	29199951	MGI
involved in response to hormone	IMP IMP: 通过突变表型推断	20616347	MGI
involved in response to luteinizing hormone	IMP IMP: 通过突变表型推断	26522847	MGI
involved in response to salt	IMP IMP: 通过突变表型推断	31220449	MGI
involved in response to wounding	IMP IMP: 通过突变表型推断	31220449	MGI
involved in sensory perception of sound	IMP IMP: 通过突变表型推断	30275816	MGI
involved in single fertilization	IMP IMP: 通过突变表型推断	22696190	MGI
involved in smooth muscle tissue development	IMP IMP: 通过突变表型推断	32901096	MGI
involved in spermatogenesis	IMP IMP: 通过突变表型推断	25012822	MGI
involved in startle response	IMP IMP: 通过突变表型推断	30275816	MGI
involved in vacuole organization	IMP IMP: 通过突变表型推断	25012822	MGI
involved in vascular wound healing	IMP IMP: 通过突变表型推断	32394795	MGI
involved in vasculogenesis	IMP IMP: 通过突变表型推断	32394795	MGI
involved in vestibulocochlear nerve development	IMP IMP: 通过突变表型推断	30275816	MGI
involved in vestibulocochlear nerve maturation	IMP IMP: 通过突变表型推断	25473838	MGI
involved in white fat cell differentiation	IMP IMP: 通过突变表型推断	32901096	MGI

细胞组分 GO 注释	逻辑证据	参考文献	来源
is active in cilium	IDA IDA: 通过直接分析推断	28054671	MGI
is active in cytoplasm	IDA IDA: 通过直接分析推断	23127564	MGI
is active in neuron projection	IDA IDA: 通过直接分析推断	23127564	MGI
is active in nucleus	IDA IDA: 通过直接分析推断	23127564	MGI

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

蛋白主名

其他名称

atrial natriuretic peptide receptor 2

ANP-B	ANPR-B
NPR-B	Nppb receptor
atrial natriuretic peptide receptor type B	guanylate cyclase B
guanylyl cyclase-B	natriuretic peptide receptor B type

目录号	产品名	作用方式	纯度	是否罕见病
HY-P3503A	Vosoritide acetate	Inhibitor	99.96%	否

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS09498	NPR2 Human Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS09500	NPRL2 Human Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS21394	Npr2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	否

直系同源

种属	基因名	来源	基因 ID
Homo sapiens	Npr2	NCBI	NCBI:4882

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。	站点地图隐私声明
粤ICP备2021105330号-3 上海工商沪公网安备31011502019417 沪(浦)应急管危经许[2021]201709(QFYS) 营业执照（三证合一）
Copyright © 2013-2026 MedChemExpress. All Rights Reserved.

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

粤ICP备2021105330号-3

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

Npr2 - natriuretic peptide receptor 2 Gene

关于 Npr2

功能概要

Npr2 基因产物(4)

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

姓名
邮箱 *

Sorry, but the email address you supplied was invalid.

Npr2 - natriuretic peptide receptor 2 Gene

关于 Npr2

功能概要

Npr2 基因产物(4)

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z