2. Gene
  3. Setd2 - SET domain containing 2 Gene

Setd2 - SET domain containing 2 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: KMT3A; 4921524K10Rik

基因 ID: 235626 | 基因类型: protein coding

关于 Setd2

功能概要

Enables Histone Methyltransferase activity (H3-K36 specific). Involved in endodermal cell differentiation; histone H3-K36 trimethylation; and stem cell differentiation. Acts upstream of or within several processes, including animal organ development; peptidyl-lysine methylation; and tube morphogenesis. Located in chromosome and nucleus. Is expressed in 1-cell stage embryo; 2-cell stage embryo; 4-cell stage embryo; 8-cell stage embryo; and inner cell mass. Human ortholog(s) of this gene implicated in carcinoma (multiple); gastrointestinal system Cancer (multiple); idiopathic pulmonary fibrosis; and malignant mesothelioma. Orthologous to human SETD2 (SET domain containing 2, histone lysine methyltransferase). [provided by Alliance of Genome Resources, Apr 2022]

Setd2 基因产物(1)

mRNA Protein Name
NM_001081340.3 NP_001074809.2 histone-lysine N-methyltransferase SETD2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables histone H3K36 methyltransferase activity IMP
IMP: 通过突变表型推断
18157086 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within angiogenesis IMP
IMP: 通过突变表型推断
20133625 MGI
acts upstream of or within cell migration involved in vasculogenesis IMP
IMP: 通过突变表型推断
20133625 MGI
acts upstream of or within coronary vasculature morphogenesis IMP
IMP: 通过突变表型推断
20133625 MGI
acts upstream of or within embryonic cranial skeleton morphogenesis IMP
IMP: 通过突变表型推断
20133625 MGI
acts upstream of or within embryonic organ development IMP
IMP: 通过突变表型推断
20133625 MGI
acts upstream of or within embryonic placenta morphogenesis IMP
IMP: 通过突变表型推断
20133625 MGI
involved in endodermal cell differentiation IMP
IMP: 通过突变表型推断
25242323 MGI
acts upstream of or within forebrain development IMP
IMP: 通过突变表型推断
20133625 MGI
acts upstream of or within mesoderm morphogenesis IMP
IMP: 通过突变表型推断
20133625 MGI
acts upstream of or within morphogenesis of a branching structure IMP
IMP: 通过突变表型推断
20133625 MGI
acts upstream of or within neural tube closure IMP
IMP: 通过突变表型推断
20133625 MGI
acts upstream of or within peptidyl-lysine trimethylation IMP
IMP: 通过突变表型推断
18157086 MGI
acts upstream of or within pericardium development IMP
IMP: 通过突变表型推断
20133625 MGI
acts upstream of or within regulation of gene expression IMP
IMP: 通过突变表型推断
20133625 MGI
acts upstream of or within stem cell development IMP
IMP: 通过突变表型推断
20133625 MGI
involved in stem cell differentiation IMP
IMP: 通过突变表型推断
25242323 MGI
acts upstream of or within vasculogenesis IMP
IMP: 通过突变表型推断
20133625 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in chromosome IDA
IDA: 通过直接分析推断
18157086 MGI
located in nucleus IDA
IDA: 通过直接分析推断
11092755 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

histone-lysine N-methyltransferase SETD2

SET domain-containing protein 2

lysine N-methyltransferase 3A

protein-lysine N-methyltransferase SETD2

相关产品

Clinical Phase
生物活性分子 (2)
目录号 产品名 作用方式
纯度 Phase
HY-136328 EZM0414 TFA Inhibitor 97.20% Phase 1
HY-144858 EZM0414 Inhibitor 99.11% Phase 1
Pre-clinical Phase
生物活性分子 (8)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-139626 EPZ-719 Inhibitor 99.00% 否
HY-173156 UNC10013 Modulator / 否
HY-P10463A ssK36 TFA Inhibitor 99.34% 否
HY-RS12742 SETD2 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-124699 MMSET-IN-1 Inhibitor / 否
HY-P10463 ssK36 Inhibitor / 否
HY-RS16976 Setd2 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS23419 Setd2 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Setd2 NCBI NCBI:29072
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