2. Gene
  3. A2M - A2m alpha-2-macroglobulin Gene

A2M - A2m alpha-2-macroglobulin Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

同用名: Mam; A2m1; A2mb; A2maa; A2MAC1

基因 ID: 24153 | 基因类型: protein coding

关于 A2M

功能概要

Enables endopeptidase inhibitor activity; identical protein binding activity; and neurotrophin binding activity. Involved in several processes, including acute inflammatory response; embryonic liver development; and luteinization. Located in extracellular space. Used to study hemolytic anemia and toxic shock syndrome. Biomarker of several diseases, including liver disease (multiple); membranous glomerulonephritis; osteonecrosis; peritonitis; and trypanosomiasis. Human ortholog(s) of this gene implicated in COVID-19; background diabetic retinopathy; multiple sclerosis; neurodegenerative disease (multiple); and obstructive lung disease. Orthologous to human A2M (alpha-2-macroglobulin). [provided by Alliance of Genome Resources, Apr 2022]

A2M 基因产物(1)

mRNA Protein Name
NM_012488.2 NP_036620.2 alpha-2-macroglobulin precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables brain-derived neurotrophic factor binding IDA
IDA: 通过直接分析推断
11813239 RGD
enables endopeptidase inhibitor activity IDA
IDA: 通过直接分析推断
19240864 RGD
enables identical protein binding IPI
IPI: 通过物理相互作用推断
94834 RGD
enables nerve growth factor binding IDA
IDA: 通过直接分析推断
11813239 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in acute inflammatory response to antigenic stimulus IEP
IEP: 通过表达模式推断
6202298 RGD
involved in acute-phase response IEP
IEP: 通过表达模式推断
2468362 RGD
involved in embryonic liver development IEP
IEP: 通过表达模式推断
2450021 RGD
involved in luteinization IEP
IEP: 通过表达模式推断
2479532 RGD
involved in negative regulation of endopeptidase activity IDA
IDA: 通过直接分析推断
19240864 RGD
involved in response to carbon dioxide IEP
IEP: 通过表达模式推断
12042906 RGD
involved in response to glucocorticoid IEP
IEP: 通过表达模式推断
2436819 RGD
involved in response to nutrient IEP
IEP: 通过表达模式推断
9446838 RGD
involved in response to prostaglandin E IEP
IEP: 通过表达模式推断
6202298 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in extracellular space IDA
IDA: 通过直接分析推断
2442306 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

alpha-2-macroglobulin

alpha-2-M

alpha-2-macroglobulin-P

相关产品

Pre-clinical Phase
生物活性分子 (6)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS00010 A2M Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-CE00893 2M2PE-CoA / 否
HY-E70525A Alpha 2 Macroglobulin, Human Plasma, Fast Form Inhibitor / 否
HY-RS18322 A2m Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS19112 Pzp Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS24800 A2m Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens A2M NCBI NCBI:2
Mus musculus A2M NCBI NCBI:232345
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