2. Gene
  3. Grin2a - glutamate ionotropic receptor NMDA type subunit 2A Gene

Grin2a - glutamate ionotropic receptor NMDA type subunit 2A Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

同用名: NR2A; GluN2A; NMDAR2A

基因 ID: 24409 | 基因类型: protein coding

关于 Grin2a

功能概要

Enables several functions, including enzyme binding activity; glutamate binding activity; and ligand-gated ion channel activity. Contributes to cation channel activity and extracellularly glutamate-gated ion channel activity. Involved in several processes, including cellular response to metal ion; central nervous system development; and modulation of chemical synaptic transmission. Located in several cellular components, including dendritic spine; postsynaptic density; and synaptic membrane. Is integral component of plasma membrane. Part of NMDA selective glutamate receptor complex. Is active in glutamatergic synapse and parallel fiber to Purkinje cell synapse. Is integral component of presynaptic membrane. Used to study hyperhomocysteinemia. Biomarker of cognitive disorder; placental insufficiency; and status epilepticus. Human ortholog(s) of this gene implicated in Huntington's disease; bipolar disorder; and schizophrenia. Orthologous to human GRIN2A (glutamate ionotropic receptor NMDA type subunit 2A). [provided by Alliance of Genome Resources, Apr 2022]

Grin2a 基因产物(1)

mRNA Protein Name
NM_012573.4 NP_036705.3 glutamate receptor ionotropic, NMDA 2A precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables ATPase binding IPI
IPI: 通过物理相互作用推断
19406213 RGD
enables NMDA glutamate receptor activity IDA
IDA: 通过直接分析推断
8428958 RGD
enables NMDA glutamate receptor activity IMP
IMP: 通过突变表型推断
17050728 RGD
enables calcium-dependent protein binding IPI
IPI: 通过物理相互作用推断
34233182 RGD
enables cell adhesion molecule binding IPI
IPI: 通过物理相互作用推断
16540568 RGD
contributes to extracellularly glutamate-gated ion channel activity IMP
IMP: 通过突变表型推断
9425000 RGD
enables glutamate binding IDA
IDA: 通过直接分析推断
22098737 RGD
enables glutamate binding IMP
IMP: 通过突变表型推断
9425000 RGD
enables glutamate receptor binding IPI
IPI: 通过物理相互作用推断
11239437 RGD
enables glutamate-gated receptor activity IDA
IDA: 通过直接分析推断
16477151 RGD
contributes to glutamate-gated receptor activity IMP
IMP: 通过突变表型推断
19154422 RGD
enables glutamate-gated receptor activity IMP
IMP: 通过突变表型推断
19240037 RGD
enables ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential EXP
EXP: 通过实验结果推断
19666514 RGD
enables ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential IDA
IDA: 通过直接分析推断
19666514 RGD
enables ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential IMP
IMP: 通过突变表型推断
19666514 RGD
contributes to monoatomic cation channel activity IDA
IDA: 通过直接分析推断
12408866 RGD
enables protein binding IPI
IPI: 通过物理相互作用推断
7569905 RGD
enables protein kinase binding IPI
IPI: 通过物理相互作用推断
11478920 RGD
enables protein tyrosine kinase binding IPI
IPI: 通过物理相互作用推断
11239437 RGD
enables protein-containing complex binding IDA
IDA: 通过直接分析推断
21544205 RGD
enables protein-containing complex binding IPI
IPI: 通过物理相互作用推断
12618293 RGD
enables scaffold protein binding IPI
IPI: 通过物理相互作用推断
20847060 RGD
enables signaling receptor binding IPI
IPI: 通过物理相互作用推断
12408866 RGD
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential IDA
IDA: 通过直接分析推断
12160751 RGD
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential IMP
IMP: 通过突变表型推断
12160751 RGD
enables voltage-gated monoatomic cation channel activity IMP
IMP: 通过突变表型推断
17050728 RGD
enables zinc ion binding IDA
IDA: 通过直接分析推断
19240037 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in action potential IMP
IMP: 通过突变表型推断
16904707 RGD
involved in auditory behavior IEP
IEP: 通过表达模式推断
30137254 RGD
involved in cellular response to amino acid stimulus IMP
IMP: 通过突变表型推断
19154422 RGD
involved in cellular response to dsRNA IEP
IEP: 通过表达模式推断
19958814 RGD
involved in cellular response to glycine IEP
IEP: 通过表达模式推断
23678131 RGD
involved in cellular response to growth factor stimulus IEP
IEP: 通过表达模式推断
19958814 RGD
involved in cellular response to lipid IEP
IEP: 通过表达模式推断
19819306 RGD
involved in cellular response to magnesium ion IEP
IEP: 通过表达模式推断
19154422 RGD
involved in cellular response to manganese ion IEP
IEP: 通过表达模式推断
19643132 RGD
involved in cellular response to zinc ion IMP
IMP: 通过突变表型推断
19240037 RGD
involved in cerebral cortex development IEP
IEP: 通过表达模式推断
19409459 RGD
involved in chemical synaptic transmission IMP
IMP: 通过突变表型推断
15306812 RGD
involved in conditioned place preference IEP
IEP: 通过表达模式推断
23506787 RGD
involved in dendritic spine organization IMP
IMP: 通过突变表型推断
26679993 RGD
involved in excitatory postsynaptic potential IMP
IMP: 通过突变表型推断
20164351 RGD
involved in hippocampus development IEP
IEP: 通过表达模式推断
19535712 RGD
involved in ionotropic glutamate receptor signaling pathway IDA
IDA: 通过直接分析推断
16477151 RGD
involved in long-term synaptic potentiation IEP
IEP: 通过表达模式推断
26088419 RGD
involved in memory IDA
IDA: 通过直接分析推断
16157280 RGD
involved in modulation of excitatory postsynaptic potential IMP
IMP: 通过突变表型推断
34233182 RGD
involved in monoatomic cation transmembrane transport IDA
IDA: 通过直接分析推断
22246434 RGD
involved in multicellular organismal response to stress IEP
IEP: 通过表达模式推断
26679226 RGD
involved in neuron development IEP
IEP: 通过表达模式推断
16477151 RGD
involved in neurotransmitter receptor transport, plasma membrane to endosome IMP
IMP: 通过突变表型推断
34233182 RGD
involved in positive regulation of excitatory postsynaptic potential IDA
IDA: 通过直接分析推断
12930820 RGD
involved in positive regulation of excitatory postsynaptic potential IMP
IMP: 通过突变表型推断
29339324 RGD
involved in positive regulation of inhibitory postsynaptic potential IMP
IMP: 通过突变表型推断
29339324 RGD
involved in positive regulation of protein targeting to membrane IMP
IMP: 通过突变表型推断
23678131 RGD
involved in positive regulation of synaptic transmission, glutamatergic IDA
IDA: 通过直接分析推断
19793963 RGD
involved in receptor recycling IMP
IMP: 通过突变表型推断
34233182 RGD
involved in regulation of ARF protein signal transduction IGI
IGI: 通过遗传相互作用推断
26884337 RGD
involved in regulation of NMDA receptor activity IMP
IMP: 通过突变表型推断
26679993 RGD
involved in regulation of long-term neuronal synaptic plasticity IMP
IMP: 通过突变表型推断
16904707 RGD
involved in regulation of membrane potential IMP
IMP: 通过突变表型推断
30544257 RGD
involved in regulation of monoatomic cation transmembrane transport IDA
IDA: 通过直接分析推断
22246434 RGD
involved in regulation of response to alcohol IEP
IEP: 通过表达模式推断
23506787 RGD
involved in response to amine IEP
IEP: 通过表达模式推断
19918184 RGD
involved in response to ammonium ion IEP
IEP: 通过表达模式推断
20084674 RGD
involved in response to calcium ion IEP
IEP: 通过表达模式推断
19761817 RGD
involved in response to carbohydrate IEP
IEP: 通过表达模式推断
19695778 RGD
involved in response to cocaine IEP
IEP: 通过表达模式推断
19322657 RGD
involved in response to environmental enrichment IEP
IEP: 通过表达模式推断
26679226 RGD
involved in response to ethanol IEP
IEP: 通过表达模式推断
19673743 RGD
involved in response to ethanol IMP
IMP: 通过突变表型推断
27876530 RGD
involved in response to fungicide IEP
IEP: 通过表达模式推断
19591855 RGD
involved in response to hydrogen sulfide IEP
IEP: 通过表达模式推断
23242725 RGD
involved in response to lead ion IEP
IEP: 通过表达模式推断
30137254 RGD
involved in response to light stimulus IEP
IEP: 通过表达模式推断
19850826 RGD
involved in response to lithium ion IDA
IDA: 通过直接分析推断
12932824 RGD
involved in response to manganese ion IEP
IEP: 通过表达模式推断
20175136 RGD
involved in response to methylmercury IEP
IEP: 通过表达模式推断
19409459 RGD
involved in response to nicotine IEP
IEP: 通过表达模式推断
16040357 RGD
involved in response to organic cyclic compound IEP
IEP: 通过表达模式推断
19322657 RGD
involved in response to other organism IEP
IEP: 通过表达模式推断
19563853 RGD
involved in response to xenobiotic stimulus IEP
IEP: 通过表达模式推断
20084674 RGD
involved in rhythmic process IDA
IDA: 通过直接分析推断
16477151 RGD
involved in spinal cord development IEP
IEP: 通过表达模式推断
19446017 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of NMDA selective glutamate receptor complex IDA
IDA: 通过直接分析推断
8702950 RGD
located in cell surface IDA
IDA: 通过直接分析推断
26088419 RGD
located in cytoplasm IDA
IDA: 通过直接分析推断
16477151 RGD
located in dendrite membrane IDA
IDA: 通过直接分析推断
23678131 RGD
located in dendritic spine IDA
IDA: 通过直接分析推断
16221859 RGD
is active in glutamatergic synapse EXP
EXP: 通过实验结果推断
19666514 RGD
is active in glutamatergic synapse IDA
IDA: 通过直接分析推断
12160751 RGD
is active in glutamatergic synapse IMP
IMP: 通过突变表型推断
12160751 RGD
located in neuron projection IDA
IDA: 通过直接分析推断
12738960 RGD
is active in parallel fiber to Purkinje cell synapse IDA
IDA: 通过直接分析推断
19666514 RGD
located in plasma membrane IDA
IDA: 通过直接分析推断
23625947 RGD
located in postsynaptic density IDA
IDA: 通过直接分析推断
9509416 RGD
located in postsynaptic density, intracellular component IDA
IDA: 通过直接分析推断
26088419 RGD
located in postsynaptic membrane IDA
IDA: 通过直接分析推断
9509416 RGD
is active in presynaptic membrane IDA
IDA: 通过直接分析推断
19666514 RGD
located in presynaptic membrane IDA
IDA: 通过直接分析推断
16157280 RGD
located in terminal bouton IDA
IDA: 通过直接分析推断
19666514 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

glutamate receptor ionotropic, NMDA 2A

N-methyl D-aspartate receptor subtype 2A

N-methyl-D-aspartate receptor subunit 2A

glutamate [NMDA] receptor subunit epsilon-1

glutamate receptor, ionotropic, N-methyl D-aspartate 2A

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS05804 GRIN2A Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS21136 Grin2a Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS27654 Grin2a Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Grin2a NCBI NCBI:2903
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z