2. Gene
  3. Pax6 - paired box 6 Gene

Pax6 - paired box 6 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

基因 ID: 25509 | 基因类型: protein coding

关于 Pax6

功能概要

Enables DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and minor groove of adenine-thymine-rich DNA binding activity. Involved in several processes, including cellular response to hormone stimulus; enteroendocrine cell differentiation; and nervous system development. Located in chromatin and nucleus. Used to study autistic disorder. Biomarker of Smith-Lemli-Opitz syndrome and transient cerebral ischemia. Human ortholog(s) of this gene implicated in bilateral optic nerve hypoplasia; eye disease (multiple); glucose intolerance; and paranoid schizophrenia. Orthologous to human PAX6 (paired box 6). [provided by Alliance of Genome Resources, Apr 2022]

Pax6 基因产物(1)

mRNA Protein Name
NM_013001.2 NP_037133.1 paired box protein Pax-6
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA-binding transcription factor activity, RNA polymerase II-specific IDA
IDA: 通过直接分析推断
20592023 RGD
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: 通过直接分析推断
20592023 RGD
enables double-stranded DNA binding IDA
IDA: 通过直接分析推断
12370174 RGD
enables minor groove of adenine-thymine-rich DNA binding IDA
IDA: 通过直接分析推断
12370174 RGD
enables sequence-specific DNA binding IDA
IDA: 通过直接分析推断
12370174 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in astrocyte differentiation IMP
IMP: 通过突变表型推断
22944581 RGD
involved in cellular response to fibroblast growth factor stimulus IEP
IEP: 通过表达模式推断
18189319 RGD
involved in cellular response to glucose stimulus IEP
IEP: 通过表达模式推断
21818840 RGD
involved in cellular response to insulin stimulus IEP
IEP: 通过表达模式推断
18189319 RGD
involved in cellular response to prostaglandin E stimulus IEP
IEP: 通过表达模式推断
23257891 RGD
involved in cellular response to xenobiotic stimulus IEP
IEP: 通过表达模式推断
19619535 RGD
involved in cerebellum development IEP
IEP: 通过表达模式推断
11688562 RGD
involved in epithelial cell development IMP
IMP: 通过突变表型推断
19393751 RGD
involved in hindbrain development IDA
IDA: 通过直接分析推断
11880342 RGD
involved in hindbrain development IMP
IMP: 通过突变表型推断
20082710 RGD
involved in insulin metabolic process IMP
IMP: 通过突变表型推断
21069736 RGD
involved in interkinetic nuclear migration IMP
IMP: 通过突变表型推断
17825043 RGD
involved in learned vocalization behavior or vocal learning IMP
IMP: 通过突变表型推断
21203536 RGD
involved in neural crest cell migration IMP
IMP: 通过突变表型推断
9079035 RGD
involved in neural precursor cell proliferation IMP
IMP: 通过突变表型推断
22944581 RGD
involved in neuron migration IMP
IMP: 通过突变表型推断
12534968 RGD
involved in olfactory bulb development IMP
IMP: 通过突变表型推断
14736749 RGD
involved in olfactory bulb mitral cell layer development IMP
IMP: 通过突变表型推断
14736749 RGD
involved in pancreatic A cell development IMP
IMP: 通过突变表型推断
20592023 RGD
involved in pancreatic A cell differentiation IMP
IMP: 通过突变表型推断
20592023 RGD
involved in positive regulation of cell fate specification IMP
IMP: 通过突变表型推断
11880342 RGD
involved in positive regulation of gene expression IMP
IMP: 通过突变表型推断
11222774 RGD
involved in positive regulation of glutamatergic neuron differentiation IMP
IMP: 通过突变表型推断
24030726 RGD
involved in positive regulation of neuron migration IGI
IGI: 通过遗传相互作用推断
11688562 RGD
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
20592023 RGD
involved in regulation of neurogenesis IMP
IMP: 通过突变表型推断
16164600 RGD
involved in regulation of neuron differentiation IDA
IDA: 通过直接分析推断
11880342 RGD
involved in regulation of neuron projection development IGI
IGI: 通过遗传相互作用推断
11688562 RGD
involved in response to ethanol IEP
IEP: 通过表达模式推断
21073715 RGD
involved in retina development in camera-type eye IEP
IEP: 通过表达模式推断
19012751 RGD
involved in rhombomere morphogenesis IMP
IMP: 通过突变表型推断
21501682 RGD
involved in sensory neuron migration IMP
IMP: 通过突变表型推断
16510508 RGD
involved in spinal cord development IEP
IEP: 通过表达模式推断
20195794 RGD
involved in type B pancreatic cell differentiation IMP
IMP: 通过突变表型推断
22403172 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in chromatin IDA
IDA: 通过直接分析推断
20592023 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

paired box protein Pax-6

oculorhombin

paired box gene 6

paired box homeotic gene 6

相关产品

Pre-clinical Phase
生物活性分子 (4)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS10093 PAX6 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-174557 Human PAX6 mRNA / 否
HY-RS20319 Pax6 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS26827 Pax6 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Pax6 NCBI NCBI:5080
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