2. Gene
  3. Pparg - peroxisome proliferator-activated receptor gamma Gene

Pparg - peroxisome proliferator-activated receptor gamma Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：过氧化物酶体增殖物激活受体 γ

种属: Rattus norvegicus

同用名: PPARgamma2

基因 ID: 25664 | 基因类型: protein coding

关于 Pparg

Primary_assembly 4: 148,423,194-148,548,468 forward strand.mRatBN7.2:CM026977.1

This gene has 2 transcripts (splice variants), 405 orthologues, 19 paralogues and is associated with 103 phenotypes. Biased expression in Thymus (RPKM 11.5), Adrenal (RPKM 13.6) and 7 other tissues.

功能概要

该基因编码的蛋白可启动多种功能，包括 DNA 结合转录因子活性；雌激素受体结合活性；和蛋白磷酸酶结合活性。参与多个过程，包括细胞分化的正调节；调控细胞大分子生物合成过程；和对维生素的反应。位于胞质溶胶中；核;和细胞质的核周区。用于研究多种疾病，包括急性肾功能衰竭；动脉疾病（多发性）；胰腺炎;多囊肾;和短暂性脑缺血。几种疾病的生物标志物，包括酒精性心肌病；糖尿病脑病;高雄激素血症;肥胖;和短暂性脑缺血。该基因的人类直系同源物与多种疾病有关，包括心血管系统疾病（多种）；晚期肾脏疾病;脂肪代谢障碍（多种）；肥胖;和 2 型糖尿病。与人 PPARG（过氧化物酶体增殖物激活受体 γ）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables several functions, including DNA-binding transcription factor activity; Estrogen receptor binding activity; and protein Phosphatase binding activity. Involved in several processes, including positive regulation of cell differentiation; regulation of cellular macromolecule biosynthetic process; and response to vitamin. Located in cytosol; nucleus; and perinuclear region of cytoplasm. Used to study several diseases, including acute kidney failure; artery disease (multiple); pancreatitis; polycystic kidney disease; and transient cerebral ischemia. Biomarker of several diseases, including alcoholic cardiomyopathy; diabetic encephalopathy; hyperandrogenism; obesity; and transient cerebral ischemia. Human ortholog(s) of this gene implicated in several diseases, including cardiovascular system disease (multiple); end stage renal disease; lipodystrophy (multiple); obesity; and type 2 diabetes mellitus. Orthologous to human PPARG (peroxisome proliferator activated receptor gamma). [provided by Alliance of Genome Resources, Apr 2022]

Pparg 基因产物(3)

mRNA Protein Name
NM_001145366.1 NP_001138838.1 peroxisome proliferator-activated receptor gamma isoform 2
NM_001145367.1 NP_001138839.1 peroxisome proliferator-activated receptor gamma isoform 2
NM_013124.3 NP_037256.1 peroxisome proliferator-activated receptor gamma isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA binding IDA
IDA: 通过直接分析推断
16257923 RGD
enables DNA-binding transcription factor activity IDA
IDA: 通过直接分析推断
19383491 RGD
enables nuclear estrogen receptor binding IPI
IPI: 通过物理相互作用推断
20689342 RGD
enables protein binding IPI
IPI: 通过物理相互作用推断
18828195 RGD
enables protein phosphatase binding IDA
IDA: 通过直接分析推断
18600431 RGD
enables transcription cis-regulatory region binding IDA
IDA: 通过直接分析推断
19383491 RGD
enables transcription coactivator binding IPI
IPI: 通过物理相互作用推断
10037764 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in animal organ regeneration IEP
IEP: 通过表达模式推断
18565023 RGD
involved in cellular response to hyperoxia IEP
IEP: 通过表达模式推断
22444276 RGD
involved in cellular response to hypoxia IDA
IDA: 通过直接分析推断
29695452 RGD
involved in cellular response to prostaglandin E stimulus IEP
IEP: 通过表达模式推断
10797535 RGD
involved in cellular response to prostaglandin stimulus IEP
IEP: 通过表达模式推断
11936221 RGD
involved in cellular response to retinoic acid IEP
IEP: 通过表达模式推断
10797535 RGD
involved in cellular response to vitamin E IEP
IEP: 通过表达模式推断
11752099 RGD
involved in fatty acid oxidation IMP
IMP: 通过突变表型推断
17003342 RGD
involved in heart development IEP
IEP: 通过表达模式推断
15754086 RGD
involved in negative regulation of acute inflammatory response IMP
IMP: 通过突变表型推断
18479673 RGD
acts upstream of or within negative regulation of cardiac muscle hypertrophy in response to stress IDA
IDA: 通过直接分析推断
29695452 RGD
involved in negative regulation of cell growth IMP
IMP: 通过突变表型推断
18600431 RGD
involved in negative regulation of cell population proliferation IMP
IMP: 通过突变表型推断
16556873 RGD
involved in negative regulation of collagen biosynthetic process IMP
IMP: 通过突变表型推断
16202214 RGD
acts upstream of or within negative regulation of connective tissue replacement involved in inflammatory response wound healing IDA
IDA: 通过直接分析推断
29695452 RGD
acts upstream of negative regulation of gene expression IGI
IGI: 通过遗传相互作用推断
28867608 RGD
involved in negative regulation of gene expression IGI
IGI: 通过遗传相互作用推断
28867608 RGD
involved in negative regulation of lipid storage IDA
IDA: 通过直接分析推断
29695452 RGD
involved in negative regulation of pancreatic stellate cell proliferation IMP
IMP: 通过突变表型推断
16202214 RGD
acts upstream of negative regulation of smooth muscle cell proliferation IGI
IGI: 通过遗传相互作用推断
28867608 RGD
acts upstream of or within positive regulation of adiponectin secretion IDA
IDA: 通过直接分析推断
29695452 RGD
involved in positive regulation of apoptotic process IMP
IMP: 通过突变表型推断
16202214 RGD
involved in positive regulation of fat cell differentiation IMP
IMP: 通过突变表型推断
27910957 RGD
involved in positive regulation of fatty acid oxidation IMP
IMP: 通过突变表型推断
18475159 RGD
involved in positive regulation of oligodendrocyte differentiation IMP
IMP: 通过突变表型推断
18543250 RGD
involved in positive regulation of phagocytosis, engulfment IMP
IMP: 通过突变表型推断
15940641 RGD
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
19383491 RGD
involved in regulation of fat cell differentiation IDA
IDA: 通过直接分析推断
10438514 RGD
involved in regulation of lipid metabolic process IMP
IMP: 通过突变表型推断
18621767 RGD
involved in regulation of transcription by RNA polymerase II IEP
IEP: 通过表达模式推断
10438514 RGD
involved in regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
16202214 RGD
involved in response to caffeine IEP
IEP: 通过表达模式推断
18486259 RGD
involved in response to estrogen IEP
IEP: 通过表达模式推断
18769493 RGD
involved in response to immobilization stress IEP
IEP: 通过表达模式推断
15820709 RGD
involved in response to linoleic acid IEP
IEP: 通过表达模式推断
18304850 RGD
involved in response to lipid IEP
IEP: 通过表达模式推断
19251397 RGD
involved in response to mechanical stimulus IEP
IEP: 通过表达模式推断
15572034 RGD
involved in response to organic cyclic compound IEP
IEP: 通过表达模式推断
18520050 RGD
involved in response to starvation IEP
IEP: 通过表达模式推断
19157823 RGD
involved in response to vitamin A IEP
IEP: 通过表达模式推断
18384703 RGD
involved in response to xenobiotic stimulus IEP
IEP: 通过表达模式推断
18846335 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in perinuclear region of cytoplasm IDA
IDA: 通过直接分析推断
15774612 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Pparg 蛋白结构

PPARgamma_N

PPARgamma_N: pfam12577 (30 - 107)

NR_DBD_Ppar

NR_DBD_Ppar: cd06965 (137 - 220)

NR_LBD_PPAR

NR_LBD_PPAR: cd06932 (236 - 503)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 505 a.a.
蛋白主名 其他名称

peroxisome proliferator-activated receptor gamma

PPAR-gamma

nuclear receptor subfamily 1 group C member 3

peroxisome proliferator activator receptor, gamma

相关产品

Pre-clinical Phase
生物活性分子 (13)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-153344 FX-909 Inhibitor 99.79% 否
HY-153364 FTX-6746 Inhibitor 99.07% 否
HY-160160 BAY-5516 Inhibitor 98.17% 否
HY-108569 nTZDpa 98.53% 否
HY-160161 BAY-5094 Inhibitor 98.04% 否
HY-RS10925 PPARG Human Pre-designed siRNA Set A / 否
HY-RS10926 Pparg Mouse Pre-designed siRNA Set A / 否
HY-W009066 2-Ethylhexyl diphenyl phosphate 94.27% 否
HY-121579 L-764406 Agonist / 否
HY-160159 PPARγ modulator-1 Modulator / 否
HY-160188 BAY-9683 Modulator / 否
HY-178447 PPARγ agonist 20 / 否
HY-RS10927 Pparg Rat Pre-designed siRNA Set A / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Pparg NCBI NCBI:5468
Mus musculus Pparg NCBI NCBI:19016
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