2. Gene
  3. Mapk9 - mitogen-activated protein kinase 9 Gene

Mapk9 - mitogen-activated protein kinase 9 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：丝裂原活化蛋白激酶 9

种属: Mus musculus

同用名: JNK2; Prkm9; p54aSAPK

基因 ID: 26420 | 基因类型: protein coding

关于 Mapk9

Chromosome 11: 49,737,578-49,777,248 forward strand.GRCm39:CM001004.3

This gene has 10 transcripts (splice variants), 221 orthologues, 19 paralogues and is associated with 20 phenotypes. Ubiquitous expression in cerebellum adult (RPKM 32.4), cortex adult (RPKM 26.9) and 28 other tissues.

功能概要

该基因编码的蛋白可启动蛋白质丝氨酸/苏氨酸/酪氨酸激酶活性。参与肽基丝氨酸磷酸化；细胞蛋白质代谢过程的正向调节；和昼夜节律的调节。作用于多个过程的上游或内部，包括凋亡信号通路的正向调节；足体组装的正调控；和蛋白质定位到三细胞紧密连接。位于胞质溶胶和线粒体中。以多种结构表达，包括大脑；胚外成分；未来的大脑；泌尿生殖系统；和脊髓。该基因的人类直系同源物与结直肠癌有关；胰腺癌；和 2 型糖尿病。与人 MAPK9（丝裂原活化蛋白激酶 9）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables protein serine/threonine/tyrosine kinase activity. Involved in peptidyl-serine phosphorylation; positive regulation of cellular protein metabolic process; and regulation of circadian rhythm. Acts upstream of or within several processes, including positive regulation of apoptotic signaling pathway; positive regulation of podosome assembly; and protein localization to tricellular tight junction. Located in cytosol and mitochondrion. Is expressed in several structures, including brain; extraembryonic component; future brain; genitourinary system; and spinal cord. Human ortholog(s) of this gene implicated in colorectal cancer; pancreatic adenocarcinoma; and type 2 diabetes mellitus. Orthologous to human MAPK9 (mitogen-activated protein kinase 9). [provided by Alliance of Genome Resources, Apr 2022]

Mapk9 基因产物(4)

mRNA Protein Name
NM_016961.3 NP_058657.1 mitogen-activated protein kinase 9 isoform beta1
NM_001163671.1 NP_001157143.1 mitogen-activated protein kinase 9 isoform beta2
NM_207692.2 NP_997575.2 mitogen-activated protein kinase 9 isoform alpha2
NM_001163672.1 NP_001157144.1 mitogen-activated protein kinase 9 isoform alpha1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables JUN kinase activity IDA
IDA: 通过直接分析推断
27830702 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
10471813 MGI
enables protein kinase activity IDA
IDA: 通过直接分析推断
24889144 MGI
enables protein serine/threonine/tyrosine kinase activity IMP
IMP: 通过突变表型推断
29153991 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of apoptotic signaling pathway IGI
IGI: 通过遗传相互作用推断
16458303 MGI
involved in inflammatory response to wounding IDA
IDA: 通过直接分析推断
27830702 MGI
involved in modulation of chemical synaptic transmission IDA
IDA: 通过直接分析推断
15816869 MGI
involved in modulation of chemical synaptic transmission IMP
IMP: 通过突变表型推断
15816869 MGI
acts upstream of or within positive regulation of apoptotic signaling pathway IGI
IGI: 通过遗传相互作用推断
16458303 MGI
involved in positive regulation of cytokine production involved in inflammatory response IDA
IDA: 通过直接分析推断
27830702 MGI
acts upstream of or within positive regulation of podosome assembly IMP
IMP: 通过突变表型推断
24127566 MGI
involved in positive regulation of proteasomal ubiquitin-dependent protein catabolic process IMP
IMP: 通过突变表型推断
29153991 MGI
involved in positive regulation of protein ubiquitination IMP
IMP: 通过突变表型推断
29153991 MGI
acts upstream of or within protein localization to tricellular tight junction IMP
IMP: 通过突变表型推断
24889144 MGI
acts upstream of or within protein phosphorylation IDA
IDA: 通过直接分析推断
24889144 MGI
involved in protein phosphorylation IMP
IMP: 通过突变表型推断
22441692 MGI
involved in regulation of circadian rhythm IMP
IMP: 通过突变表型推断
22441692 MGI
acts upstream of or within response to cadmium ion IGI
IGI: 通过遗传相互作用推断
16458303 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in Schaffer collateral - CA1 synapse IDA
IDA: 通过直接分析推断
15816869 MGI
is active in Schaffer collateral - CA1 synapse IMP
IMP: 通过突变表型推断
15816869 MGI
is active in cytoplasm IDA
IDA: 通过直接分析推断
27830702 MGI
located in cytoplasm IMP
IMP: 通过突变表型推断
29153991 MGI
located in cytosol IDA
IDA: 通过直接分析推断
11884367 MGI
located in mitochondrion IDA
IDA: 通过直接分析推断
11884367 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Mapk9 蛋白结构

STKc_JNK

STKc_JNK: cd07850 (24 - 359)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 423 a.a.
蛋白主名 其他名称

mitogen-activated protein kinase 9

JNK/SAPK alpha

Jun kinase

MAP kinase 9

MAPK 9

c-Jun N-terminal kinase 2

protein kinase, mitogen-activated 9

stress-activated protein kinase JNK2

相关产品

Pre-clinical Phase
生物活性分子 (5)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-148063 DB0614 98.80% 否
HY-148061 DB1113 99.22% 否
HY-RS08127 MAPK9 Human Pre-designed siRNA Set A / 否
HY-RS08128 Mapk9 Mouse Pre-designed siRNA Set A / 否
HY-RS08129 Mapk9 Rat Pre-designed siRNA Set A / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Mapk9 NCBI NCBI:5601
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