2. Gene
  3. OLA1 - Obg like ATPase 1 Gene

OLA1 - Obg like ATPase 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：Obg 样 ATPase 1

种属: Homo sapiens

同用名: DOC45; GBP45; GTBP9; GTPBP9; PTD004

基因 ID: 29789 | 基因类型: protein coding

关于 OLA1

Cytogenetic location: 2q31.1 Genomic coordinates (GRCh38): 2:174,072,447-174,248,532 (from NCBI)

This gene has 9 transcripts (splice variants) and 281 orthologues. Ubiquitous expression in brain (RPKM 15.5), thyroid (RPKM 14.3) and 25 other tissues.

功能概要

该基因编码 GTPase 蛋白家族的一个成员。编码的蛋白质与乳腺癌相关基因 1 (BRCA1) 和 BRCA1 相关环结构域蛋白 (BARD1) 相互作用，并参与中心体调节。已在多种类型的癌症中观察到该基因的过度表达，并且可能与生存率低有关。该基因的假基因已在 17 号和 22 号染色体上定义。[RefSeq 提供，2016 年 6 月]

This gene encodes a member of the GTPase protein family. The encoded protein interacts with breast cancer-associated gene 1 (BRCA1) and BRCA1-associated RING domain protein (BARD1), and is involved in centrosome regulation. Overexpression of this gene has been observed in multiple types of Cancer and may be associated with poor survival. Pseudogenes of this gene have been defined on chromosomes 17 and 22. [provided by RefSeq, Jun 2016]

OLA1 基因产物(3)

mRNA Protein Name
NM_001011708.3 NP_001011708.1 obg-like ATPase 1 isoform 2
NM_001328688.2 NP_001315617.1 obg-like ATPase 1 isoform 3
NM_013341.5 NP_037473.3 obg-like ATPase 1 isoform 1
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables ATP binding IDA
IDA: 通过直接分析推断
17430889 GOA
enables ATP hydrolysis activity IDA
IDA: 通过直接分析推断
17430889 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
22190034 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in ATP metabolic process IDA
IDA: 通过直接分析推断
17430889 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

OLA1 蛋白结构

MMR_HSR1

MMR_HSR1: 50S ribosome-binding GTPase (24 - 131)

YchF-GTPase_C

YchF-GTPase_C: Protein of unknown function (DUF933) (305 - 388)

  • 0
  • 100
  • 200
  • 300
  • 396 a.a.
蛋白主名 其他名称

obg-like ATPase 1

DNA damage-regulated overexpressed in cancer 45 protein

OLA1 抗体

目录号 产品名 应用 反应物种
HY-P89906 GTPBP9 Antibody (YA9250) WB, ICC/IF, IF-Tissue, IP, ELISA human, mouse, rat

关联疾病

疾病名称 别名
Breast Cancer

Breast Carcinoma

Male Breast Cancer

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation
Hereditary Breast Ovarian Cancer Syndrome

Hereditary Breast And Ovarian Cancer Syndrome

Brca1- And Brca2-Associated Hereditary Breast And Ovarian Cancer

Breast And/Or Ovarian Cancer

Breast And Ovarian Cancer Syndrome

Hboc Syndrome

Hereditary Breast And Ovarian Cancer

Brca1- Brca2-Associated Hboc
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (4)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS09768 OLA1 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-174563 Human OLA1 mRNA / 否
HY-RS18961 Ola1 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS25452 Ola1 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta OLA1 VGNC VGNC:97800
Rattus norvegicus OLA1 RGD RGD:1307982
Canis familiaris OLA1 VGNC VGNC:44112
Mus musculus OLA1 MGD MGI:1914309
Bos taurus OLA1 VGNC VGNC:32416
Others OLA1 NCBI
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