2. Gene
  3. Kdm2b - lysine (K)-specific demethylase 2B Gene

Kdm2b - lysine (K)-specific demethylase 2B Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Cxxc2; Fbl10; PCCX2; Fbxl10; Jhdm1b

基因 ID: 30841 | 基因类型: protein coding

关于 Kdm2b

功能概要

The protein encoded by this gene is a H3K36-specific Histone Demethylase, which contains an N-terminal jumonji C domain, a CxxC zinc finger domain, a plant homeodomain finger, an F-box, and eight leucine-rich repeats. Amongst its demonstrated functions, this protein plays roles in the suppression of premature cellular senescence, leukemia maintenance and development, maintenance of mouse embryonic stem cell pluripotency, and induced pluripotent stem cell generation. Mice homozygous for a targeted deletion of the zinc finger domain display embryonic lethality with development ceasing at approximately 7 to 8 days post coitum, demonstrating an essential role in early development. A pseudogene of this gene is found on chromosome 4. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]

Kdm2b 基因产物(5)

mRNA Protein Name
NM_001003953.2 NP_001003953.1 lysine-specific demethylase 2B isoform 1
NM_001378863.1 NP_001365792.1 lysine-specific demethylase 2B isoform 3
NM_001378864.1 NP_001365793.1 lysine-specific demethylase 2B isoform 4
NM_001378865.1 NP_001365794.1 lysine-specific demethylase 2B isoform 5
NM_013910.2 NP_038938.1 lysine-specific demethylase 2B isoform 2
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: 通过直接分析推断
21245044 MGI
enables histone H3K36 demethylase activity IDA
IDA: 通过直接分析推断
21540074 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
17296600 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in embryonic camera-type eye morphogenesis IMP
IMP: 通过突变表型推断
21220025 MGI
involved in forebrain development IMP
IMP: 通过突变表型推断
21220025 MGI
involved in fourth ventricle development IMP
IMP: 通过突变表型推断
21220025 MGI
involved in hindbrain development IMP
IMP: 通过突变表型推断
21220025 MGI
involved in initiation of neural tube closure IMP
IMP: 通过突变表型推断
21220025 MGI
involved in lateral ventricle development IMP
IMP: 通过突变表型推断
21220025 MGI
involved in midbrain development IMP
IMP: 通过突变表型推断
21220025 MGI
involved in midbrain-hindbrain boundary morphogenesis IMP
IMP: 通过突变表型推断
21220025 MGI
involved in negative regulation of neural precursor cell proliferation IMP
IMP: 通过突变表型推断
21220025 MGI
involved in negative regulation of neuron apoptotic process IMP
IMP: 通过突变表型推断
21220025 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
21540074 MGI
involved in negative regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
21220025 MGI
acts upstream of or within positive regulation of cell growth IDA
IDA: 通过直接分析推断
21540074 MGI
acts upstream of or within positive regulation of stem cell population maintenance IDA
IDA: 通过直接分析推断
21540074 MGI
involved in spermatogenesis IMP
IMP: 通过突变表型推断
21220025 MGI
involved in third ventricle development IMP
IMP: 通过突变表型推断
21220025 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

lysine-specific demethylase 2B

F-box and leucine-rich repeat protein 10

F-box protein FBL10

F-box protein containing leucine repeats 10

F-box/LRR-repeat protein 10

[Histone-H3]-lysine-36 demethylase 1B

jmjC domain-containing histone demethylation protein 1B

相关产品

Pre-clinical Phase
生物活性分子 (8)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-129079 TFMB-(R)-2-HG Inhibitor 98.26% 否
HY-139561 KDM2B-IN-2 99.36% 否
HY-139601 KDM2B-IN-4 Inhibitor 99.61% 否
HY-139560 KDM2B-IN-1 Inhibitor 99.49% 否
HY-RS07210 KDM2B Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-139600 KDM2B-IN-3 Inhibitor / 否
HY-RS16813 Kdm2b Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS23253 Kdm2b Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Kdm2b NCBI NCBI:84678
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