2. Gene
  3. E2f1 - E2F transcription factor 1 Gene

E2f1 - E2F transcription factor 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

基因 ID: 399489 | 基因类型: protein coding

关于 E2f1

功能概要

Enables protein kinase binding activity and sequence-specific DNA binding activity. Involved in several processes, including cellular response to hypoxia; cellular response to nerve growth factor stimulus; and positive regulation of glial cell proliferation. Located in cytoplasm and nucleus. Biomarker of Huntington's disease and pancreatic Cancer. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma; lung small cell carcinoma; lung squamous cell carcinoma; pancreatic adenocarcinoma; and pancreatic ductal adenocarcinoma. Orthologous to human E2F1 (E2F transcription factor 1). [provided by Alliance of Genome Resources, Apr 2022]

E2f1 基因产物(1)

mRNA Protein Name
NM_001100778.1 NP_001094248.1 transcription factor E2F1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
9697699 RGD
enables protein kinase binding IPI
IPI: 通过物理相互作用推断
18367454 RGD
enables sequence-specific DNA binding IDA
IDA: 通过直接分析推断
18096822 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to fatty acid IEP
IEP: 通过表达模式推断
19180667 RGD
involved in cellular response to hypoxia IEP
IEP: 通过表达模式推断
19088195 RGD
involved in cellular response to nerve growth factor stimulus IDA
IDA: 通过直接分析推断
18367454 RGD
involved in positive regulation of glial cell proliferation IMP
IMP: 通过突变表型推断
21637599 RGD
involved in spermatogenesis IEP
IEP: 通过表达模式推断
17147820 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in nuclear chromosome IDA
IDA: 通过直接分析推断
24250814 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

transcription factor E2F1

E2F-1

相关产品

Pre-clinical Phase
生物活性分子 (7)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-162384 EPIC-0628 Inhibitor 98.93% 否
HY-117857 MRT00033659 99.77% 否
HY-RS04110 E2F1 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-175397 Dth Degrader / 否
HY-RS15353 UBE2L3 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS17052 E2f1 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS23496 E2f1 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens E2f1 NCBI NCBI:1869
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