MARK3 - microtubule affinity regulating kinase 3 Gene

中文名称：微管亲和力调节激酶 3

种属: Homo sapiens

同用名: KP78; VIPB; CTAK1; PAR1A; Par-1a

基因 ID: 4140 | 基因类型: protein coding

关于 MARK3

Cytogenetic location: 14q32.32-q32.33 Genomic coordinates (GRCh38): 14:103,385,415-103,503,831 (from NCBI)

This gene has 81 transcripts (splice variants), 206 orthologues, 3 paralogues and is associated with 2 phenotypes. Ubiquitous expression in bone marrow (RPKM 22.5), testis (RPKM 17.6) and 25 other tissues.

功能概要

该基因编码的蛋白质被磷酸化激活，进而参与 tau 蛋白 MAP2 和 MAP4 的磷酸化。已发现该基因编码不同亚型的几种转录变体。[RefSeq 提供，2011 年 10 月]

The protein encoded by this gene is activated by phosphorylation and in turn is involved in the phosphorylation of tau proteins MAP2 and MAP4. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

MARK3 基因产物(7)

mRNA	Protein	Name
NM_001128918.3	NP_001122390.2	MAP/microtubule affinity-regulating kinase 3 isoform a
NM_001128919.3	NP_001122391.2	MAP/microtubule affinity-regulating kinase 3 isoform b
NM_001128920.3	NP_001122392.2	MAP/microtubule affinity-regulating kinase 3 isoform d
NM_001128921.3	NP_001122393.2	MAP/microtubule affinity-regulating kinase 3 isoform e
NM_001411055.1	NP_001397984.1	MAP/microtubule affinity-regulating kinase 3 isoform f
NM_001411056.1	NP_001397985.1	MAP/microtubule affinity-regulating kinase 3 isoform g
NM_002376.7	NP_002367.5	MAP/microtubule affinity-regulating kinase 3 isoform c

MARK3 蛋白结构

Pkinase

KA1

0
200
400
600
753 a.a.

蛋白主名

其他名称

MAP/microtubule affinity-regulating kinase 3

C-TAK1

MARK3 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	MARK3	P27448	RIMS1	Homo sapiens	Q86UR5	Anti Bait CoIP	37207277
种属内	MARK3	P27448	HCN1	Homo sapiens	O60741	Anti Bait CoIP	37207277
种属间	MARK3	P27448	ORF9b	Human SARS coronavirus	Q6S8E0	Y2H Pooling	22046132
种属间	MARK3	P27448	ORF9b	Human SARS coronavirus	Q6S8E0	Lumier	22046132
种属内	MARK3	P27448	YWHAH	Homo sapiens	Q04917	Anti Tag CoIP	16959763
种属内	MARK3	P27448	YWHAH	Homo sapiens	Q04917	Pull Down	32707033
种属内	MARK3	P27448	YWHAH	Homo sapiens	Q04917	Anti Tag CoIP	35271311
种属内	MARK3	P27448	YWHAZ	Homo sapiens	P63104	Pull Down	32707033
种属内	MARK3	P27448	YWHAZ	Homo sapiens	P63104	Anti Tag CoIP	35271311
种属内	MARK3	P27448	YWHAZ	Homo sapiens	P63104	Far-WB	15161933
种属内	MARK3	P27448	YWHAZ	Homo sapiens	P63104	Pull Down	15161933
种属内	MARK3	P27448	YWHAZ	Homo sapiens	P63104	Anti Tag CoIP	25852190
种属内	MARK3	P27448	YWHAZ	Homo sapiens	P63104	TAP	16306228
种属内	MARK3	P27448	YWHAZ	Homo sapiens	P63104	Anti Tag CoIP	16959763
种属内	MARK3	P27448	YWHAE	Homo sapiens	P62258	Crosslink	36931259
种属内	MARK3	P27448	YWHAE	Homo sapiens	P62258	Pull Down	32707033
种属内	MARK3	P27448	YWHAE	Homo sapiens	P62258	Anti Tag CoIP	35271311
种属内	MARK3	P27448	YWHAE	Homo sapiens	P62258	TAP	16306228
种属内	MARK3	P27448	YWHAB	Homo sapiens	P31946	Pull Down	32707033
种属内	MARK3	P27448	YWHAB	Homo sapiens	P31946	CoIP	15324660
种属内	MARK3	P27448	YWHAB	Homo sapiens	P31946	Anti Tag CoIP	35271311
种属内	MARK3	P27448	YWHAB	Homo sapiens	P31946	Anti Tag CoIP	16959763
种属内	MARK3	P27448	YWHAG	Homo sapiens	P61981	CoIP	15324660
种属内	MARK3	P27448	YWHAG	Homo sapiens	P61981	Anti Tag CoIP	16959763
种属内	MARK3	P27448	YWHAG	Homo sapiens	P61981	Anti Tag CoIP	35271311
种属内	MARK3	P27448	YWHAG	Homo sapiens	P61981	Pull Down	32707033
种属内	MARK3	P27448	SFN	Homo sapiens	P31947	TAP	15778465
种属内	MARK3	P27448	ASB13	Homo sapiens	Q8WXK3	Y2H Pooling	16169070
种属间	MARK3	P27448	Ppm1l	Mus musculus	Q8BHN0	Phosphatase Assay	12556533
种属间	MARK3	P27448	Ppm1l	Mus musculus	Q8BHN0	Anti Bait CoIP	12556533

种属间: 跨种属相互作用 种属内: 同种属相互作用

MARK3 抗体

目录号	产品名	应用	反应物种
HY-P82405	MARK3 Antibody (YA2150)	WB, ICC/IF, IP, FC	Mouse, Human
HY-P84225	MARK3 Antibody (YA3922)	WB, IHC-P, FC, ELISA	Human, Mouse, Rat,

关联疾病

疾病名称

别名

Visual Impairment And Progressive Phthisis Bulbi

VIPB	Eye Diseases

Peutz-Jeghers Syndrome

PJS	Polyposis, Hamartomatous Intestinal
Polyps-And-Spots Syndrome	Lentiginosis, Perioral
Periorificial Lentiginosis Syndrome	Hamartomatous Intestinal Polyposis
Hamartomatous Polyp	Colonic Hamartomatous Polyp
Gastric Peutz-Jeghers Polyp	Peutz Jeghers Colon Polyp
Peutz Jeghers Polyp	Peutz-Jeghers Polyp Of Small Intestine
Peutz-Jeghers Small Bowel Hamartoma	Peutz Jeghers Polyposis
Intestinal Polyposis-Cutaneous Pigmentation Syndrome	Peutz-Jeghers Polyposis
Polyposis, Intestinal, Ii	Intestinal Hamartomatous Polyposis
Peutz-Jeghers Polyp	Peutz-Jeghers Polyp Of The Stomach
Peutz Jehgers Polyp	Peutz-Jeghers Polyps Of Small Bowel

Acute Cystitis

Urinary Tract Infection

Recurrent Urinary Tract Infection

Gaucher Disease, Type Iii

Gaucher Disease, Subacute Neuronopathic Type	Gd Iii
Gaucher Disease, Chronic Neuronopathic Type	Gaucher Disease, Juvenile And Adult, Cerebral
Gaucher Disease Type 3	GD3
Gaucher'S Disease Type Iii	Gaucher Disease Type Iii
Gd 3	Cerebral Juvenile And Adult Form Of Gaucher Disease
Chronic Neuronopathic Gaucher Disease	Gaucher Disease 3
Cerebral, Juvenile And Adult, Gaucher Disease	Gaucher Disease Chronic Neuronopathic Type
Gaucher Disease Type Ii	Subacute Neuronopathic Gaucher Disease
Type 3 Gaucher Disease	Gaucher Disease, Type 3
Gaucher Disease, Type 2

Osteoporosis

Postmenopausal Osteoporosis	Osteoporosis, Postmenopausal
Bone Mineral Density Quantitative Trait Locus	Bmnd
Osteoporosis, Involutional	Osteoporosis, Susceptibility To
Osteoporosis, Postmenopausal, Susceptibility	Bone Mineral Density Variation Qtl, Osteoporosis
OSTEOP	Involutional Osteoporosis
Senile Osteoporosis	Osteoporosis Postmenopausal
Bone Mineral Density, Quantitative Trait Locus	Osteoporosis, Senile
Idiopathic Osteoporosis	Bone Rarefaction Nos
Type 1 Osteoporosis

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-139604	PCC0208017		99.52%	否
HY-120877	MRT199665		99.74%	否
HY-120877A	(R)-MRT199665		98.70%	否
HY-RS08151	MARK3 Human Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS17916	Mark3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS24385	Mark3 Rat Pre-designed siRNA Set A	Pre-designed Set	/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	MARK3	MGD	MGI:1341865
Canis familiaris	MARK3	VGNC	VGNC:43025
Macaca mulatta	MARK3	VGNC	VGNC:74659
Bos taurus	MARK3	VGNC	VGNC:31249
Felis catus	MARK3	VGNC	VGNC:68185
Rattus norvegicus	MARK3	RGD	RGD:619883

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