MDM4 - MDM4 regulator of p53 Gene

中文名称：p53 的 MDM4 调节器

种属: Homo sapiens

同用名: HDMX; MDMX; MRP1; BMFS6

基因 ID: 4194 | 基因类型: protein coding

关于 MDM4

Cytogenetic location: 1q32.1 Genomic coordinates (GRCh38): 1:204,516,406-204,558,120 (from NCBI)

This gene has 16 transcripts (splice variants), 218 orthologues, 1 paralogue and is associated with 75 phenotypes. Ubiquitous expression in bone marrow (RPKM 9.7), skin (RPKM 6.5) and 24 other tissues.

功能概要

该基因编码的核蛋白在 N 端包含一个 p53 结合结构域，在 C 端包含一个环指结构域，并显示出与 p53 结合蛋白 MDM2 的结构相似性。这两种蛋白质都与 p53 肿瘤抑制蛋白结合并抑制其活性，并已被证明在多种人类癌症中过度表达。然而，与降解 p53 的 MDM2 不同，该蛋白通过结合其转录激活域来抑制 p53。该蛋白还通过 RING 指结构域与 MDM2 蛋白相互作用，并抑制后者的降解。因此，这种蛋白质可以逆转 p53 的 MDM2 靶向降解，同时保持对 p53 反式激活和凋亡功能的抑制。已经注意到该基因编码不同亚型的可变剪接转录物变体。[RefSeq 提供，2011 年 2 月]

This gene encodes a nuclear protein that contains a p53 binding domain at the N-terminus and a RING finger domain at the C-terminus, and shows structural similarity to p53-binding protein MDM2. Both proteins bind the p53 tumor suppressor protein and inhibit its activity, and have been shown to be overexpressed in a variety of human cancers. However, unlike MDM2 which degrades p53, this protein inhibits p53 by binding its transcriptional activation domain. This protein also interacts with MDM2 protein via the RING finger domain, and inhibits the latter's degradation. So this protein can reverse MDM2-targeted degradation of p53, while maintaining suppression of p53 transactivation and apoptotic functions. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Feb 2011]

MDM4 基因产物(7)

mRNA	Protein	Name
NM_001204171.2	NP_001191100.1	protein Mdm4 isoform 2
NM_001204172.2	NP_001191101.1	protein Mdm4 isoform 3
NM_001278516.2	NP_001265445.1	protein Mdm4 isoform 4
NM_001278517.2	NP_001265446.1	protein Mdm4 isoform 5
NM_001278518.2	NP_001265447.1	protein Mdm4 isoform 6
NM_001278519.2	NP_001265448.1	protein Mdm4 isoform 7
NM_002393.5	NP_002384.2	protein Mdm4 isoform 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables enzyme binding	IPI IPI: 通过物理相互作用推断	19838211	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	10469568	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in DNA damage response, signal transduction by p53 class mediator	IEP IEP: 通过表达模式推断	14660608	GOA
involved in cellular response to hypoxia	IEP IEP: 通过表达模式推断	20810912	GOA
involved in negative regulation of DNA-templated transcription	IDA IDA: 通过直接分析推断	9271120	GOA
involved in negative regulation of protein catabolic process	IMP IMP: 通过突变表型推断	10608892	GOA
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: 通过直接分析推断	9226370	GOA
involved in protein stabilization	IEP IEP: 通过表达模式推断	10608892	GOA
involved in protein-containing complex assembly	IDA IDA: 通过直接分析推断	10608892	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of transcription repressor complex	IPI IPI: 通过物理相互作用推断	8875929	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

MDM4 蛋白结构

SWIB

zf-RanBP

zf-C3HC4_3

0
100
200
300
400
490 a.a.

蛋白主名

其他名称

protein Mdm4

MDM4, p53 regulator

MDM4 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	MDM4	O15151	CAPN7	Homo sapiens	Q7Z479	Y2H Prey Pooling	25416956
种属内	MDM4	O15151	CSNK1A1	Homo sapiens	P48729	Anti Tag CoIP	33961781
种属内	MDM4	O15151	ZKSCAN3	Homo sapiens	Q9BRR0	Validated Y2H	32296183
种属内	MDM4	O15151	RNF115	Homo sapiens	Q9Y4L5	Validated Y2H	25416956
种属内	MDM4	O15151	MKRN3	Homo sapiens	Q13064	Validated Y2H	27107012
种属内	MDM4	O15151	MKRN3	Homo sapiens	Q13064	Validated Y2H	32296183
种属内	MDM4	O15151	USP7	Homo sapiens	Q93009	Anti Bait CoIP	15916963
种属内	MDM4	O15151	USP7	Homo sapiens	Q93009	Anti Tag CoIP	15916963
种属内	MDM4	O15151	USP7	Homo sapiens	Q93009	Pull Down	15916963
种属内	MDM4	O15151	YWHAZ	Homo sapiens	P63104	Anti Tag CoIP	28514442
种属内	MDM4	O15151	YWHAZ	Homo sapiens	P63104	Anti Tag CoIP	16511560
种属内	MDM4	O15151	UBE2D2	Homo sapiens	P62837	GMS	20705607
种属内	MDM4	O15151	UBE2D2	Homo sapiens	P62837	Ubiquitinase Assay	20705607
种属内	MDM4	O15151	YWHAE	Homo sapiens	P62258	Crosslink	36931259
种属内	MDM4	O15151	YWHAE	Homo sapiens	P62258	CoIP	18356162
种属内	MDM4	O15151	YWHAE	Homo sapiens	P62258	CoIP	16227609
种属内	MDM4	O15151	YWHAE	Homo sapiens	P62258	Anti Tag CoIP	16511560
种属内	MDM4	O15151	YWHAG	Homo sapiens	P61981	Anti Tag CoIP	16511572
种属内	MDM4	O15151	YWHAG	Homo sapiens	P61981	Anti Tag CoIP	16511560
种属内	MDM4	O15151	YWHAG	Homo sapiens	P61981	Anti Bait CoIP	16511572
种属内	MDM4	O15151	YWHAG	Homo sapiens	P61981	Pull Down	16511572
种属内	MDM4	O15151	TP53	Homo sapiens	P04637	ITC	19255450
种属内	MDM4	O15151	TP53	Homo sapiens	P04637	Anti Tag CoIP	33961781
种属内	MDM4	O15151	TP53	Homo sapiens	P04637	ITC	20515689
种属内	MDM4	O15151	TP53	Homo sapiens	P04637	Anti Bait CoIP	19521340
种属内	MDM4	O15151	TP53	Homo sapiens	P04637	Ubiquitinase Assay	20705607
种属内	MDM4	O15151	TP53	Homo sapiens	P04637	NMR	20515689
种属内	MDM4	O15151	MDM2	Homo sapiens	Q00987	Y2H	21988832
种属内	MDM4	O15151	MDM2	Homo sapiens	Q00987	Imaging	17159902
种属内	MDM4	O15151	MDM2	Homo sapiens	Q00987	Anti Bait CoIP	17159902
种属内	MDM4	O15151	MDM2	Homo sapiens	Q00987	Anti Tag CoIP	33961781
种属内	MDM4	O15151	MDM2	Homo sapiens	Q00987	CoIP	10608892
种属内	MDM4	O15151	MDM2	Homo sapiens	Q00987	Y2H Array	22493164
种属内	MDM4	O15151	MDM2	Homo sapiens	Q00987	Anti Tag CoIP	17159902
种属内	MDM4	O15151	CD160	Homo sapiens	O95971	Validated Y2H	32296183
种属内	MDM4	O15151	CD160	Homo sapiens	O95971	Y2H Array	25416956
种属内	MDM4	O15151	S100B	Homo sapiens	P04271	FPS	31837246
种属内	MDM4	O15151	RB1	Homo sapiens	P06400	Anti Tag CoIP	16510145
种属内	MDM4	O15151	RB1	Homo sapiens	P06400	Anti Bait CoIP	16510145
种属内	MDM4	O15151	WDR5	Homo sapiens	P61964	Validated Y2H	32296183
种属内	MDM4	O15151	S100A5	Homo sapiens	P33763	FPS	31837246
种属内	MDM4	O15151	S100A1	Homo sapiens	P23297	FPS	31837246
种属内	MDM4	O15151	NAA10	Homo sapiens	P41227	Validated Y2H	32296183
种属内	MDM4	O15151	S100A2	Homo sapiens	P29034	FPS	31837246
种属内	MDM4	O15151	BCL2	Homo sapiens	P10415	Anti Bait CoIP	19521340
种属内	MDM4	O15151	q3yba8_human	Homo sapiens	Q3YBA8	Anti Tag CoIP	16511560
种属内	MDM4	O15151	AIRIM	Homo sapiens	Q9NX04	Validated Y2H	32296183
种属间	MDM4	O15151	p03255-2	Human adenovirus C	P03255-2	Pull Down	15604276

种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 MDM4 蛋白

目录号	产品名	蛋白编号	纯度
HY-P74756	MDM4/MDMX Protein, Human (His)	O15151-1/NP_002384.2 (M1-D134)	≥ 95%, as determined by reducing SDS-PAGE.

MDM4 抗体

目录号	产品名	应用	反应物种
HY-P85272	MDMX Antibody (YA4964)	WB, IHC-P, FC, ELISA	Human

关联疾病

疾病名称

别名

Bone Marrow Failure Syndrome 6

BMFS6

Intraocular Retinoblastoma

Pediatric Intraocular Retinoblastoma

Retinoblastoma

RB	Trilateral Retinoblastoma
RB1	Retinoblastoma, Trilateral
Neuroblastoma Of Retina	Rb - Retinoblastoma
Eye Cancer, Retinoblastoma	Retinal Cancer
Retinal Tumor	Glioma, Retinal
Non-Hereditary Retinoblastoma	Childhood Cancer Retinoblastoma
Malignant Neoplasm Of Retina	Retinal Neoplasms

Extraocular Retinoblastoma

Pediatric Extraocular Retinoblastoma

Bilateral Retinoblastoma

Unilateral Retinoblastoma

Leukocoria

Leucocoria

Glioblastoma

Glioblastoma Multiforme	Gbm
Adult Glioblastoma Multiforme	Grade Iv Adult Astrocytic Tumor
Primary Glioblastoma Multiforme	Spongioblastoma Multiforme
Adult Glioblastoma	Primary Glioblastoma

Burkitt Lymphoma

Burkitt'S Lymphoma	BL
Burkitt Lymphoma, Somatic	Burkitt Lymphoma/Leukaemia
Burkitt'S Tumor	Burkitt'S Tumor Or Lymphoma
Malignant Lymphoma, Burkitt'S Type	Small Non-Cleaved Cell Lymphoma, Burkitt'S Type
Small Non-Cleaved Cell Lymphoma	Burkitt Tumor
Burkitts Lymphoma	Lymphoma, Small Noncleaved-Cell
Burkitt Tumour	Diffuse Small Noncleaved Malignant Burkitt Lymphoma
Malignant Burkitt Lymphoma	“Burkitt-Like” Lymphoma
Undifferentiated Burkitt Lymphoma	Small Noncleaved Cell Burkitt Lymphoma

Li-Fraumeni Syndrome

Sarcoma Family Syndrome Of Li And Fraumeni	Sbla Syndrome
LFS	Li-Fraumeni Familiar Cancer Susceptibility Syndrome
Sarcoma, Breast, Leukaemia And Adrenal Gland Syndrome	Lfs1
Li Fraumeni Syndrome	Sarcoma, Breast, Leukemia, And Adrenal Gland Syndrome
Lfl	Sbla Syndrome Li-Fraumeni-Like Syndrome
Li-Fraumeni Syndrome 1

Familial Retinoblastoma

Hereditary Retinoblastoma

Retinoblastoma

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-148409	MMRi62		99.59%	否
HY-10412	CEP-1347		98.50%	否
HY-W097753	4-MDM		99.64%	否
HY-123544	RDR03871	MDM2 Inhibitor	/	否
HY-146806	YL93	Inhibitor	/	否
HY-151169	MDM2/4-p53-IN-1	MDM2 Inhibitor	/	否
HY-151170	MDM2/4-p53-IN-2		/	否
HY-151171	MDM2/4-p53-IN-3	Inhibitor	/	否
HY-RS08267	MDM4 Human Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS16923	Mdm4 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS23366	Mdm4 Rat Pre-designed siRNA Set A	Pre-designed Set	/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	MDM4	MGD	MGI:107934
Canis familiaris	MDM4	VGNC	VGNC:43107
Felis catus	MDM4	VGNC	VGNC:68224
Macaca mulatta	MDM4	VGNC	VGNC:74693
Rattus norvegicus	MDM4	RGD	RGD:1309306
Bos taurus	MDM4	VGNC	VGNC:31337
Others	MDM4	NCBI

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粤ICP备2021105330号-3

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

MDM4 - MDM4 regulator of p53 Gene

关于 MDM4

功能概要

MDM4 基因产物(7)

MDM4 蛋白结构

MDM4 蛋白互作信息

重组 MDM4 蛋白

MDM4 抗体

关联疾病

直系同源

热门区域

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MDM4 - MDM4 regulator of p53 Gene

关于 MDM4

功能概要

MDM4 基因产物(7)

MDM4 蛋白结构

MDM4 蛋白互作信息

重组 MDM4 蛋白

MDM4 抗体

关联疾病

相关产品

直系同源

热门区域

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B

C

F

G

H

J

L

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Q

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T

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