2. Gene
  3. Lats2 - large tumor suppressor 2 Gene

Lats2 - large tumor suppressor 2 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: 4932411G09Rik

基因 ID: 50523 | 基因类型: protein coding

关于 Lats2

功能概要

Predicted to enable ATP binding activity and protein serine/threonine kinase activity. Involved in G1/S transition of mitotic cell cycle; negative regulation of protein localization to nucleus; and regulation of transforming growth factor beta receptor signaling pathway. Acts upstream of or within several processes, including hippo signaling; inner cell mass cell differentiation; and keratinocyte differentiation. Located in spindle pole. Is expressed in several structures, including central nervous system; eye; genitourinary system; gut; and immune system. Orthologous to human LATS2 (large tumor suppressor kinase 2). [provided by Alliance of Genome Resources, Apr 2022]

Lats2 基因产物(2)

mRNA Protein Name
NM_015771.2 NP_056586.2 serine/threonine-protein kinase LATS2 isoform 1
NM_153382.1 NP_700431.1 serine/threonine-protein kinase LATS2 isoform 2
基因本体论
  • 生物过程
  • 细胞组分
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in G1/S transition of mitotic cell cycle IDA
IDA: 通过直接分析推断
15343267 MGI
acts upstream of canonical Wnt signaling pathway IGI
IGI: 通过遗传相互作用推断
21512031 MGI
acts upstream of or within hippo signaling IGI
IGI: 通过遗传相互作用推断
18369314 MGI
acts upstream of or within inner cell mass cell fate commitment IGI
IGI: 通过遗传相互作用推断
23824537 MGI
acts upstream of or within inner cell mass cellular morphogenesis IGI
IGI: 通过遗传相互作用推断
23824537 MGI
acts upstream of or within keratinocyte differentiation IGI
IGI: 通过遗传相互作用推断
18369314 MGI
acts upstream of or within negative regulation of canonical Wnt signaling pathway IGI
IGI: 通过遗传相互作用推断
21512031 MGI
involved in negative regulation of protein localization to nucleus IMP
IMP: 通过突变表型推断
21145499 MGI
acts upstream of or within protein localization IDA
IDA: 通过直接分析推断
19289085 MGI
acts upstream of or within protein localization IGI
IGI: 通过遗传相互作用推断
19289085 MGI
acts upstream of or within protein phosphorylation IDA
IDA: 通过直接分析推断
19289085 MGI
acts upstream of or within regulation of organ growth IMP
IMP: 通过突变表型推断
21512031 MGI
involved in regulation of transforming growth factor beta receptor signaling pathway IMP
IMP: 通过突变表型推断
21145499 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in spindle pole IDA
IDA: 通过直接分析推断
15343267 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

serine/threonine-protein kinase LATS2

kinase phosphorylated during mitosis protein

large tumor suppressor homolog 2

serine/threonine-protein kinase kpm

相关产品

Pre-clinical Phase
生物活性分子 (13)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-138489 TRULI Modulator 99.98% 否
HY-147082 GA-017 Activator 98.95% 否
HY-W087830 L-p-Boronophenylalanine 99.79% 否
HY-147165 VT02956 Inhibitor 99.58% 否
HY-130504 Propargyl-PEG1-acid 97.0% 否
HY-164254 Cardiomyocyte proliferation promoting agent-1 Inhibitor 99.87% 否
HY-175649 LATS1/2-IN-1 Inhibitor / 否
HY-RS07537 LAT2 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS07539 LATS2 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-147165A VT02956 hydrochloride Inhibitor / 否
HY-RS18181 Lats2 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS21361 Lat2 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS24655 Lats2 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Lats2 NCBI NCBI:26524
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