2. Gene
  3. Tyk2 - tyrosine kinase 2 Gene

Tyk2 - tyrosine kinase 2 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：酪氨酸激酶 2

种属: Mus musculus

同用名: JTK1

基因 ID: 54721 | 基因类型: protein coding

关于 Tyk2

Chromosome 9: 21,015,364-21,042,539 reverse strand.GRCm39:CM001002.3

This gene has 6 transcripts (splice variants), 197 orthologues, 32 paralogues and is associated with 43 phenotypes. Ubiquitous expression in spleen adult (RPKM 21.7), mammary gland adult (RPKM 15.9) and 28 other tissues.

功能概要

预测该基因编码的蛋白编码的蛋白可启动生长激素受体结合活性；蛋白酪氨酸激酶活性；和 1 型血管紧张素受体结合活性。预计参与细胞内信号转导和蛋白磷酸化。预测作用于磷酸化上游或内部。预测位于细胞质和细胞核中。用于研究肥胖。该基因与免疫缺陷 35 相关的人类直系同源物。与人类 TYK2（酪氨酸激酶 2）直系同源。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable growth hormone receptor binding activity; protein tyrosine kinase activity; and type 1 Angiotensin Receptor binding activity. Predicted to be involved in intracellular signal transduction and protein phosphorylation. Predicted to act upstream of or within phosphorylation. Predicted to be located in cytoplasm and nucleus. Used to study obesity. Human ortholog(s) of this gene implicated in immunodeficiency 35. Orthologous to human Tyk2 (tyrosine kinase 2). [provided by Alliance of Genome Resources, Apr 2022]

Tyk2 基因产物(2)

mRNA Protein Name
NM_001205312.1 NP_001192241.1 non-receptor tyrosine-protein kinase TYK2 isoform 1
NM_018793.2 NP_061263.2 non-receptor tyrosine-protein kinase TYK2 isoform 2
基因本体论
  • 生物过程
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cell population proliferation IGI
IGI: 通过遗传相互作用推断
15781341 MGI
involved in positive regulation of T cell proliferation IDA
IDA: 通过直接分析推断
11114383 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Tyk2 蛋白结构

FERM_F1

FERM_F1: pfam18379 (32 - 127)

FERM_F2

FERM_F2: pfam18377 (145 - 268)

Jak1_Phl

Jak1_Phl: pfam17887 (287 - 430)

SH2

SH2: cl15255 (435 - 533)

PKc_like

PKc_like: cl21453 (588 - 863)

PTKc_Tyk2_rpt2

PTKc_Tyk2_rpt2: cd05080 (888 - 1170)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1000
  • 1184 a.a.
蛋白主名 其他名称

non-receptor tyrosine-protein kinase TYK2

tyrosine kinase TYK2

相关产品

Approval
生物活性分子 (19)
目录号 产品名 作用方式
纯度 是否罕见病
HY-50856 Ruxolitinib Inhibitor 99.99% 是
HY-19569 Upadacitinib Inhibitor 99.98% 是
HY-15315 Baricitinib Inhibitor 99.97% 是
HY-117287 Deucravacitinib Inhibitor 99.93% 否
HY-50858 Ruxolitinib phosphate Inhibitor 99.97% 是
HY-16379 Pacritinib Inhibitor 99.93% 是
HY-18300 Filgotinib Inhibitor 99.77% 是
HY-107429 Abrocitinib Inhibitor 99.26% 否
HY-19568 Peficitinib Inhibitor 99.43% 是
HY-15315A Baricitinib phosphate Inhibitor 99.97% 是
HY-109053 Delgocitinib Inhibitor 99.61% 否
HY-13577 Oclacitinib Inhibitor 99.59% 否
HY-13577A Oclacitinib monomaleate Inhibitor 99.87% 否
HY-18300A Filgotinib maleate Inhibitor 99.88% 是
HY-50859 Ruxolitinib sulfate Inhibitor / 否
HY-19568A Peficitinib hydrobromide Inhibitor / 否
HY-19569A Upadacitinib tartrate tetrahydrate Inhibitor / 否
HY-16379A Pacritinib hydrochloride Inhibitor / 否
HY-19568B Peficitinib hydrochloride Inhibitor / 否
Clinical Phase
生物活性分子 (12)
目录号 产品名 作用方式
纯度 Phase
HY-15999 Cerdulatinib Inhibitor 99.06% Phase 3
HY-12469 Decernotinib Inhibitor 99.91% Phase 3
HY-112724 Ivarmacitinib Inhibitor 99.62% Phase 3
HY-15999A Cerdulatinib hydrochloride Inhibitor 98.96% Phase 3
HY-174905 Quecitinib Inhibitor 98.58% Phase 3
HY-13034 Gandotinib Inhibitor 99.86% Phase 2
HY-15270 BMS-911543 Inhibitor 98.23% Phase 2
HY-19631A Ilginatinib Inhibitor 99.94% Phase 2
HY-156961 Cadefrecitinib Inhibitor 99.81% Phase 2
HY-19631B Ilginatinib hydrochloride Inhibitor 98.92% Phase 2
HY-19631 Ilginatinib maleate Inhibitor 99.87% Phase 2
HY-101024 PF-06263276 Inhibitor ≥99.0% Phase 1
Pre-clinical Phase
生物活性分子 (53)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-14435 Pyridone 6 Inhibitor 98.20% 否
HY-14722 NVP-BSK805 Inhibitor 99.30% 否
HY-100895 SAR-20347 Inhibitor 97.27% 否
HY-131968 BMS-986202 Inhibitor 99.29% 否
HY-113787 (R)-9b Inhibitor 99.51% 否
HY-160144S Lomedeucitinib Inhibitor 99.75% 否
HY-14722A NVP-BSK805 dihydrochloride Inhibitor 99.36% 否
HY-101762 TyK2-IN-2 Inhibitor 99.05% 否
HY-16640 TCJL37 Inhibitor 99.89% 否
HY-126242S Tyk2-IN-7 Inhibitor 99.58% 否
HY-111745 Tyk2-IN-5 Inhibitor 99.35% 否
HY-131906 JAK2-IN-7 Inhibitor 98.31% 否
HY-150720 TYK2-IN-12 Inhibitor 98.81% 否
HY-120469 2,6-Dichloro-N-(2-(cyclopropanecarboxamido)pyridin-4-yl)benzamide Inhibitor 99.80% 否
HY-153440 Methyl 6-(1-(4-methoxybenzyl)-1H-pyrazol-4-yl)-4-oxo-4,5-dihydropyrazolo[1,5-a]pyrazine-2-carboxylate Inhibitor 98.01% 否
HY-153701S Envudeucitinibum Inhibitor 99.56% 否
HY-111750 JAK-IN-3 Inhibitor 98.92% 否
HY-13961 GLPG0634 analog Inhibitor 98.07% 否
HY-126141 JAK/HDAC-IN-1 Inhibitor 98.63% 否
HY-152080 Blovacitinib Inhibitor 99.71% 否
HY-159536 Frevecitinib Inhibitor / 否
HY-170772 Dual Cathepsin L/JAK-IN-1 Inhibitor 98.47% 否
HY-18710 BMS-066 Inhibitor 99.09% 否
HY-148060 JAK-IN-21 Inhibitor 99.72% 否
HY-18315 Bayer-18 Inhibitor / 否
HY-14722C NVP-BSK805 trihydrochloride Inhibitor / 否
HY-N14094 Tubulosine Inhibitor / 否
HY-175983 JAK1/TYK2-IN-5 Inhibitor / 否
HY-168269 Tyk2-IN-20 Inhibitor / 否
HY-143885 JAK1/TYK2-IN-3 Inhibitor / 否
HY-173359 TYK2 ligand 2 Ligand / 否
HY-168339 Tyk2-IN-22 Inhibitor / 否
HY-178282 JAK1-IN-19 Inhibitor / 否
HY-163304 Tyk2-IN-16 Inhibitor / 否
HY-175684 JAK2-IN-14 Inhibitor / 否
HY-149296 JAK1-IN-12 Inhibitor / 否
HY-158692 Tyk2-IN-18 Inhibitor / 否
HY-149283 JAK/HDAC-IN-2 Inhibitor / 否
HY-176793 JAK1-IN-18 Inhibitor / 否
HY-175310S Voderdeucitinib Inhibitor / 否
HY-181278 Deucravacitinib analog 1 / 否
HY-112783 TYK2 ligand 4 Ligand / 否
HY-143884 JAK2/TYK2-IN-1 Inhibitor / 否
HY-153058 LRRK2-IN-8 Inhibitor / 否
HY-153103 LRRK2/NUAK1/TYK2-IN-1 Inhibitor / 否
HY-147754 JAK3/BTK-IN-6 Inhibitor / 否
HY-177130S Socrodeucitinib Inhibitor / 否
HY-154994 JAK-IN-30 Inhibitor / 否
HY-123187 AS2553627 Inhibitor / 否
HY-162862 JAK-IN-38 Inhibitor / 否
HY-157121 JAK-IN-34 Inhibitor / 否
HY-162862 JAK-IN-38 Inducer / 否
HY-18709 Tyk2-IN-3 Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Tyk2 NCBI NCBI:7297
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