2. Gene
  3. LARP6 - La ribonucleoprotein 6, translational regulator Gene

LARP6 - La ribonucleoprotein 6, translational regulator Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：La 核糖核蛋白 6，翻译调节器

种属: Homo sapiens

同用名: ACHN

基因 ID: 55323 | 基因类型: protein coding

关于 LARP6

Cytogenetic location: 15q23 Genomic coordinates (GRCh38): 15:70,829,130-70,854,157 (from NCBI)

This gene has 5 transcripts (splice variants), 205 orthologues and 6 paralogues. Broad expression in brain (RPKM 22.8), thyroid (RPKM 15.1) and 17 other tissues.

功能概要

启用 RNA 结合活性和肌球蛋白结合活性。参与胶原蛋白生物合成过程的正向调控； mRNA 结合活性的正调节；和翻译的积极调节。位于核内。多核糖体的一部分。 [由基因组资源联盟提供，2022 年 4 月]

Enables RNA binding activity and Myosin binding activity. Involved in positive regulation of Collagen biosynthetic process; positive regulation of mRNA binding activity; and positive regulation of translation. Located in nucleus. Part of polysome. [provided by Alliance of Genome Resources, Apr 2022]

LARP6 基因产物(3)

mRNA Protein Name
NM_001286679.2 NP_001273608.1 la-related protein 6 isoform 3
NM_018357.4 NP_060827.2 la-related protein 6 isoform 1
NM_197958.3 NP_932062.1 la-related protein 6 isoform 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables RNA stem-loop binding IDA
IDA: 通过直接分析推断
20603131 GOA
enables RNA stem-loop binding IMP
IMP: 通过突变表型推断
21746880 GOA
enables mRNA 5'-UTR binding IDA
IDA: 通过直接分析推断
20603131 GOA
enables mRNA 5'-UTR binding IMP
IMP: 通过突变表型推断
21746880 GOA
enables myosin binding IPI
IPI: 通过物理相互作用推断
20603131 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
20603131 GOA
enables sequence-specific mRNA binding IDA
IDA: 通过直接分析推断
22190748 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in positive regulation of collagen biosynthetic process IMP
IMP: 通过突变表型推断
21746880 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
20603131 GOA
located in cytoplasm IMP
IMP: 通过突变表型推断
21746880 GOA
located in nucleus IDA
IDA: 通过直接分析推断
21746880 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

LARP6 蛋白结构

La

La: La domain (96 - 155)

SUZ-C

SUZ-C: SUZ-C motif (452 - 482)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 491 a.a.
蛋白主名 其他名称

la-related protein 6

La ribonucleoprotein domain family member 6

关联疾病

疾病名称 别名
Ovarian Endometrial Cancer

Endometrioid Neoplasm Of Ovary

Malignant Ovarian Endometrioid Tumor

Ovarian Endometrioid Neoplasm
Retrograde Amnesia

Amnesia, Retrograde
Brittle Bone Disorder

Osteogenesis Imperfecta

Brittle Bone Disease

Fragilitas Ossium

Osteopsathyrosis

Lobstein Disease

Oi

Vrolik Disease

Lobstein'S Disease

Lobstein'S Syndrome

Vrolik'S Disease

Porak And Durante Disease

Glass Bone Disease

Osteogenesis Imperfecta, Dominant Perinatal Lethal

Osteogenesis Imperfecta, Recessive Perinatal Lethal

Brittle Bone Syndrome

Oi - [Osteogenesis Imperfecta]

Ossium Fragility

Osteitis Fragilitans

Bony Fragility

Blue Sclera With Fragility Of Bone And Deafness

White Blue Sclera - Fragility Of Bone - Deafness
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS07530 LARP6 Human Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus LARP6 VGNC VGNC:63195
Mus musculus LARP6 MGD MGI:1914807
Rattus norvegicus LARP6 RGD RGD:1308414
Canis familiaris LARP6 VGNC VGNC:42590
Bos taurus LARP6 VGNC VGNC:30793
Macaca mulatta LARP6 VGNC VGNC:74107
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