2. Gene
  3. Pbrm1 - polybromo 1 Gene

Pbrm1 - polybromo 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Pb1; BAF180; 2610016F04Rik

基因 ID: 66923 | 基因类型: protein coding

关于 Pbrm1

功能概要

Enables chromatin binding activity. Acts upstream of or within blastocyst formation; heart development; and placenta development. Located in kinetochore. Is expressed in brain; early conceptus; genitourinary system; and heart. Human ortholog(s) of this gene implicated in extrahepatic bile duct adenocarcinoma; lung non-small cell carcinoma; lung small cell carcinoma; and renal cell carcinoma. Orthologous to human PBRM1 (polybromo 1). [provided by Alliance of Genome Resources, Apr 2022]

Pbrm1 基因产物(6)

mRNA Protein Name
NM_001081251.1 NP_001074720.1 protein polybromo-1 isoform 1
NM_001359854.1 NP_001346783.1 protein polybromo-1 isoform 2
NM_001359855.1 NP_001346784.1 protein polybromo-1 isoform 3
NM_001359856.1 NP_001346785.1 protein polybromo-1 isoform 4
NM_001359857.1 NP_001346786.1 protein polybromo-1 isoform 5
NM_001359858.1 NP_001346787.1 protein polybromo-1 isoform 5
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables chromatin binding IDA
IDA: 通过直接分析推断
15601824 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
17640523 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within blastocyst formation IMP
IMP: 通过突变表型推断
27869233 MGI
acts upstream of or within heart development IMP
IMP: 通过突变表型推断
15601824 MGI
acts upstream of or within placenta development IMP
IMP: 通过突变表型推断
15601824 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of SWI/SNF superfamily-type complex IDA
IDA: 通过直接分析推断
24335282 MGI
located in kinetochore IDA
IDA: 通过直接分析推断
14519686 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

protein polybromo-1

2310032M22Rik

BRG1-associated factor 180

相关产品

Approval
生物活性分子 (1)
目录号 产品名 作用方式
纯度 是否罕见病
HY-171774 PBRM1/SMARCA2,4-ligand-1 / 否
Pre-clinical Phase
生物活性分子 (19)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-128359 ACBI1 99.92% 否
HY-163410 AU-24118 Degrader 99.10% 否
HY-149026 GNE-064 Inhibitor 99.65% 否
HY-151532 PBRM1-BD2-IN-5 Inhibitor 99.75% 否
HY-151538 PBRM1-BD2-IN-8 Inhibitor 98.05% 否
HY-150289 GNE-235 98.86% 否
HY-151529 PBRM1-BD2-IN-2 Inhibitor ≥99.0% 否
HY-151528 PBRM1-BD2-IN-1 Inhibitor / 否
HY-151530 PBRM1-BD2-IN-3 Inhibitor / 否
HY-151531 PBRM1-BD2-IN-4 Inhibitor / 否
HY-151533 PBRM1-BD2-IN-6 Inhibitor / 否
HY-151534 PBRM1-BD2-IN-7 Inhibitor / 否
HY-161881 SMARCA2-IN-9 Inhibitor / 否
HY-174237 PBRM1/SMARCA2,4 binder-1 / 否
HY-175756 SMARCA2/4 degrader-1 Degrader / 否
HY-183007 LJM133 Degrader / 否
HY-RS10105 PBRM1 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS17918 Pbrm1 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS24387 Pbrm1 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Pbrm1 NCBI NCBI:55193
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