2. Gene
  3. Appl1 - adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1 Gene

Appl1 - adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: DIP13; 2900057D21Rik; 7330406P05Rik

基因 ID: 72993 | 基因类型: protein coding

关于 Appl1

功能概要

Predicted to enable several functions, including beta-tubulin binding activity; phospholipid binding activity; and protein homodimerization activity. Involved in several processes, including cellular response to hepatocyte growth factor stimulus; positive regulation of cytokine production involved in inflammatory response; and regulation of vesicle-mediated transport. Located in cytoplasmic vesicle and ruffle. Is expressed in several structures, including liver; muscle tissue; spleen; stomach; and testis. Human ortholog(s) of this gene implicated in maturity-onset diabetes of the young type 14. Orthologous to human APPL1 (adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1). [provided by Alliance of Genome Resources, Apr 2022]

Appl1 基因产物(1)

mRNA Protein Name
NM_145221.3 NP_660256.1 DCC-interacting protein 13-alpha
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
19661063 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to hepatocyte growth factor stimulus IMP
IMP: 通过突变表型推断
26445298 MGI
involved in negative regulation of Fc-gamma receptor signaling pathway involved in phagocytosis IMP
IMP: 通过突变表型推断
25568335 MGI
involved in positive regulation of cytokine production involved in inflammatory response IMP
IMP: 通过突变表型推断
25328665 MGI
involved in positive regulation of macropinocytosis IMP
IMP: 通过突变表型推断
27219021 MGI
involved in regulation of fibroblast migration IMP
IMP: 通过突变表型推断
26445298 MGI
involved in regulation of innate immune response IMP
IMP: 通过突变表型推断
27219021 MGI
involved in regulation of toll-like receptor 4 signaling pathway IMP
IMP: 通过突变表型推断
27219021 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in early endosome IDA
IDA: 通过直接分析推断
21849472 MGI
located in early phagosome IDA
IDA: 通过直接分析推断
25568335 MGI
located in endosome IDA
IDA: 通过直接分析推断
25568335 MGI
located in macropinosome IDA
IDA: 通过直接分析推断
27219021 MGI
located in ruffle IDA
IDA: 通过直接分析推断
25568335 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

DCC-interacting protein 13-alpha

DIP13 alpha

adapter protein containing PH domain, PTB domain and leucine zipper motif 1

adaptor protein APPL like

dip13-alpha

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS00867 APPL1 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS20366 Appl1 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS26876 Appl1 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Appl1 NCBI NCBI:26060
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