2. Gene
  3. Glis2 - GLIS family zinc finger 2 Gene

Glis2 - GLIS family zinc finger 2 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Nkl; Gli5; Klf16

基因 ID: 83396 | 基因类型: protein coding

关于 Glis2

功能概要

Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in negative regulation of smoothened signaling pathway and regulation of transcription, DNA-templated. Acts upstream of or within several processes, including hematopoietic stem cell homeostasis; positive regulation of protein localization to nucleus; and regulation of transcription by RNA polymerase II. Located in cytoplasm; non-motile cilium; and nuclear speck. Is expressed in several structures, including early conceptus; gut; nervous system; oocyte; and retina layer. Used to study nephronophthisis 7. Human ortholog(s) of this gene implicated in nephronophthisis 7. Orthologous to human GLIS2 (GLIS family zinc finger 2). [provided by Alliance of Genome Resources, Apr 2022]

Glis2 基因产物(1)

mRNA Protein Name
NM_031184.3 NP_112461.2 zinc finger protein GLIS2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA binding IDA
IDA: 通过直接分析推断
11262234 MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: 通过直接分析推断
21127075 MGI
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
IDA: 通过直接分析推断
18298960 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
17344476 MGI
enables transcription cis-regulatory region binding IDA
IDA: 通过直接分析推断
21127075 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within cell differentiation involved in kidney development IMP
IMP: 通过突变表型推断
17618285 MGI
acts upstream of or within hematopoietic stem cell homeostasis IMP
IMP: 通过突变表型推断
26880577 MGI
acts upstream of or within kidney development IMP
IMP: 通过突变表型推断
18227149 MGI
involved in negative regulation of DNA-binding transcription factor activity IDA
IDA: 通过直接分析推断
21127075 MGI
involved in negative regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
11741991 MGI
involved in negative regulation of smoothened signaling pathway IMP
IMP: 通过突变表型推断
21816948 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
17618285 MGI
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
21127075 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
17618285 MGI
involved in positive regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
11741991 MGI
acts upstream of or within positive regulation of protein localization to nucleus IGI
IGI: 通过遗传相互作用推断
17344476 MGI
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
21127075 MGI
acts upstream of or within regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
18227149 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in non-motile cilium IDA
IDA: 通过直接分析推断
17618285 MGI
located in nuclear speck IDA
IDA: 通过直接分析推断
11741991 MGI
located in nucleus IDA
IDA: 通过直接分析推断
18227149 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

zinc finger protein GLIS2

GLI-Kruppel family member GLI5

GLI-similar 2

Kruppel-like factor 16 (neuronal)

neuronal Krueppel-like protein

zinc finger protein GLI5

相关产品

Pre-clinical Phase
生物活性分子 (9)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-13901 GANT 61 99.80% 否
HY-RS05475 GLI2 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-12487 NL-103 Inhibitor / 否
HY-137567 Prostaglandin E1 ethanolamide Activator / 否
HY-RS05481 GLIS2 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS20743 Gli2 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS21582 Glis2 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS27255 Gli2 Rat Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS28100 Glis2 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Glis2 NCBI NCBI:84662
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