H6PD - hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase Gene

中文名称：6-磷酸己糖脱氢酶/1-葡萄糖脱氢酶

种属: Homo sapiens

同用名: GDH; G6PDH; H6PDH; CORTRD1

基因 ID: 9563 | 基因类型: protein coding

关于 H6PD

Cytogenetic location: 1p36.22 Genomic coordinates (GRCh38): 1:9,234,774-9,271,337 (from NCBI)

This gene has 3 transcripts (splice variants), 198 orthologues, 1 paralogue and is associated with 2 phenotypes. Ubiquitous expression in ovary (RPKM 12.8), skin (RPKM 11.6) and 25 other tissues.

功能概要

葡萄糖-6-磷酸脱氢酶有两种形式。 G 形式是 X 连锁的，由该基因编码的 H 形式是常染色体连锁的。这种 H 形式对其他 6-磷酸己糖 (尤其是 6-磷酸半乳糖) 表现出活性，而 G 形式对 6-磷酸葡萄糖具有特异性。两种形式都存在于大多数组织中，但在红细胞中未发现 H 形式。[RefSeq 提供，2008 年 7 月]

There are 2 forms of glucose-6-phosphate dehydrogenase. G form is X-linked and H form, encoded by this gene, is autosomally linked. This H form shows activity with Other hexose-6-phosphates, especially galactose-6-phosphate, whereas the G form is specific for glucose-6-phosphate. Both forms are present in most tissues, but H form is not found in red cells. [provided by RefSeq, Jul 2008]

H6PD 基因产物(2)

mRNA	Protein	Name
NM_001282587.2	NP_001269516.1	GDH/6PGL endoplasmic bifunctional protein isoform 1 precursor
NM_004285.4	NP_004276.2	GDH/6PGL endoplasmic bifunctional protein isoform 2 precursor

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables glucose-6-phosphate dehydrogenase activity	IDA IDA: 通过直接分析推断	18628520	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in pentose-phosphate shunt, oxidative branch	IMP IMP: 通过突变表型推断	18628520	GOA
involved in regulation of cortisol biosynthetic process	IMP IMP: 通过突变表型推断	18628520	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in endoplasmic reticulum lumen	IDA IDA: 通过直接分析推断	18628520	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

H6PD 蛋白结构

G6PD_N

G6PD_C

Glucosamine_iso

0
200
400
600
791 a.a.

蛋白主名

其他名称

GDH/6PGL endoplasmic bifunctional protein

6-phosphogluconolactonase

关联疾病

疾病名称

别名

Cortisone Reductase Deficiency 1

CORTRD1

Cortisone Reductase Deficiency, Type 1

Cortisone Reductase Deficiency

11-Alpha Beta-Hydroxysteroid Dehydrogenase Type I Deficiency Of	Cortrd
Hsd 11b1 Deficiency

Hyperandrogenism Due To Cortisone Reductase Deficiency

11-Beta-Hydroxysteroid Dehydrogenase Deficiency Type 1

Glucosephosphate Dehydrogenase Deficiency

G6pd Deficiency	Glucose-6-Phosphate Dehydrogenase Deficiency
Deficiency Of Glucose-6-Phosphate Dehydrogenase	Glucose 6 Phosphate Dehydrogenase Deficiency
Deficiency Of G-6pd	G6pdd

Parotitis

Scleromalacia Perforans

Type 2 Diabetes Mellitus

Insulin Resistance	NIDDM
Type 2 Diabetes	Diabetes Mellitus, Non-Insulin-Dependent
T2D	Noninsulin-Dependent Diabetes Mellitus
Diabetes Mellitus, Type Ii	Maturity-Onset Diabetes
Insulin Resistance, Severe, Digenic	Diabetes Mellitus, Type 2
Diabetes Mellitus, Noninsulin-Dependent	Diabetes Mellitus, Noninsulin-Dependent, Association With
Diabetes Mellitus, Noninsulin-Dependent, Late Onset	Hypertension, Insulin Resistance-Related, Susceptibility To
Insulin Resistance, Susceptibility To	Non-Insulin-Dependent Diabetes Mellitus
Type Ii Diabetes Mellitus	Adult-Onset Diabetes Mellitus
Maturity-Onset Diabetes Mellitus	Diabetes Mellitus Type 2
Type Ii Diabetes	Type 2 Diabetes Mellitus, Susceptibility To
Diabetes, Type 2	Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To
Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To	Diabetes Mellitus, Type 2, Susceptibility To
Diabetes Mellitus, Noninsulin-Dependent, 2	Diabetes Mellitus, Type Ii, Susceptibility To
Hypertension, Insulin Resistance-Related	Adult-Onset Diabetes
Aodm	Diabetes Mellitus, Adult-Onset
Diabetes Mellitus Type Ii	Diabetes Mellitus Type 2, Susceptibility To
Diabetes, Type Ii, Susceptibility To	Diabetes Type 2
Diabetes Mellitus	Adult Onset Diabetes
Maturity Onset Diabetes	Nonketotic Diabetes
Non-Insulin Dependent Diabetes Mellitus	T2dm - [Type 2 Diabetes Mellitus]
Niddm - [Non Insulin Dependent Diabetes Mellitus]	Dm2
Dm Type Ii	Diabetic Type 2
Insulin Requiring Type 2 Diabetes	Noninsulin Dependent Diabetes
Non-Insulin-Dependent Diabetes Mellitus Without Complications	Diabetes Due To Insulin Secretory Defect
Diabetes Mellitus Due To Insulin Secretory Defect	Non-Insulin-Dependent Diabetes Of The Young
Senile Diabetes	Nonketotic Hyperglycaemia
Stable Diabetes

Diabetes Mellitus

Diabetes

Body Mass Index Quantitative Trait Locus 11

OBESITY	Obesity, Susceptibility To
Leanness, Inherited	Obesity, Susceptibility To, Bmiq11
Obesity, Mild, Early-Onset	Obesity, Association With
Obesity, Early-Onset, Susceptibility To	Obesity, Severe
Obesity, Severe, And Type Ii Diabetes	Obesity, Late-Onset
Obesity , Susceptibility To	BMIQ11
Obesity Bmiq11	Obesity, Early-Onset
Simple Obesity Nos	Excess Fat
Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified	Adiposis

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

目录号	产品名	作用方式	纯度	是否罕见病
HY-10617A	Rucaparib	Inhibitor	99.97%	是
HY-10617	Rucaparib phosphate	Inhibitor	99.76%	是
HY-102003	Rucaparib (monocamsylate)	Inhibitor	99.91%	是
HY-102003A	Rucaparib camsylate	Inhibitor	/	否
HY-10617C	Rucaparib tartrate	Inhibitor	/	否
HY-10617B	Rucaparib hydrochloride	Inhibitor	/	否
HY-10617D	Rucaparib acetate	Inhibitor	/	否

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS05980	H6PD Human Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-10617AS	Rucaparib-d8	Inhibitor	/	否
HY-RS17126	H6pd Mouse Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS23571	H6pd Rat Pre-designed siRNA Set A	Pre-designed Set	/	否

直系同源

种属	基因名	来源	基因 ID
Macaca mulatta	H6PD	VGNC	VGNC:73340
Rattus norvegicus	H6PD	RGD	RGD:1306562
Mus musculus	H6PD	MGD	MGI:2140356
Felis catus	H6PD	VGNC	VGNC:67529
Canis familiaris	H6PD	VGNC	VGNC:41579

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

粤ICP备2021105330号-3

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

H6PD - hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase Gene

关于 H6PD

功能概要

H6PD 基因产物(2)

H6PD 蛋白结构

关联疾病

直系同源

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H6PD - hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase Gene

关于 H6PD

功能概要

H6PD 基因产物(2)

H6PD 蛋白结构

关联疾病

相关产品

直系同源

热门区域

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B

C

F

G

H

J

L

N

Q

S

T

X

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