2. Cell Cycle/DNA Damage
  3. Topoisomerase
  4. GI-149893

GI-149893是一种选择性的拓扑异构酶 I (TopoI) 抑制剂。GI-149893 能阻止 DNA 的重新连接，并在肿瘤细胞中引发不可逆的 DNA 损伤。GI-149893 有望用于癌症的研究 (如结肠癌 HT-29/SW-48、乳腺癌 MX-1、前列腺癌 PC-3 肿瘤移植模型) 的研究。

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GI-149893

GI-149893 Chemical Structure

CAS No. : 149809-18-7

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GI-149893 相关抗体

Top Publications Citing Use of Products

查看 Topoisomerase 亚型特异性产品:

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Topoisomerase Topo I Topo II DNA gyrase

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

GI-149893 is a selective topoisomerase I (TopoI) inhibitor. GI-149893 prevents DNA religation and induces irreversible DNA damage in tumor cells. GI-149893 is promising for research of cancers (e.g., colon carcinoma HT-29/SW-48, breast MX-1, prostate PC-3 xenografts)[1][2].

IC50 & Target

Topoisomerase I

 

分子量

504.53

Formula

C27H28N4O6
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

GI-149893 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GI-149893149809-18-7GI149893GI 149893TopoisomeraseTopoIDNA damagecancersInhibitorinhibitorinhibit

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产品名称：
GI-149893
目录号：
HY-131438
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