2. Immunology/Inflammation NF-κB Metabolic Enzyme/Protease Apoptosis
  3. Reactive Oxygen Species (ROS) Apoptosis Keap1-Nrf2 Heme Oxygenase (HO) Bcl-2 Family
  4. Ginsenoside Ia

Ginsenoside Ia 是一种三萜皂苷类化合物。Ginsenoside Ia 可通过抗氧化和凋亡通路发挥神经保护作用。Ginsenoside Ia 可缓解 H2O2 诱导的神经元损伤、降低 ROS 水平、抑制细胞凋亡 (apoptosis) 并稳定线粒体。Ginsenoside Ia 可用于神经退行性疾病的研究。

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Ginsenoside Ia

Ginsenoside Ia Chemical Structure

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Ginsenoside Ia 相关抗体

Top Publications Citing Use of Products

查看 Heme Oxygenase (HO) 亚型特异性产品:

查看所有亚型
HO-1 HO-2

查看 Bcl-2 Family 亚型特异性产品:

查看所有亚型
Bcl-2 Bcl-xL Bcl-W Mcl-1 Bfl-1 Bcl-B Bax Bak Bim BNIP3 Bad

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Ginsenoside Ia is a triterpenoid saponin compound. Ginsenoside Ia exerts neuroprotective effects through antioxidant and apoptotic pathways. Ginsenoside Ia alleviates H2O2-induced neuronal damage, reduces ROS levels, inhibits cell apoptosis, and stabilizes mitochondria. Ginsenoside Ia is applicable in research on neurodegenerative diseases[1].

IC50 & Target[1]

Bcl-2

 

HO-1

 

体外研究
(In Vitro)

Ginsenoside Ia (Compound 1) (2.5-50 μM；24 h) 可强效保护 PC12 细胞免受 H2O2 诱导的损伤 (EC50 为 6.74 μM)，降低细胞内 ROS 水平和维持线粒体膜电位[1]。
Ginsenoside Ia (2.5-10 μM；24 h) 可调控 Keap1/Nrf2/ARE 通路，并降低 H2O2 诱导的 PC12 细胞中 Bax/Bcl-2 的比值[1]。

Ginsenoside Ia (2.5-10 μM；24 小时) 可剂量依赖性地抑制 H2O2 诱导的 PC12 细胞凋亡[1]。
Ginsenoside Ia (2.5-10 μM；24 h) 可在 H2O2 诱导的 PC12 细胞中促进 Nrf2 的核转位[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Ginsenoside Ia 相关抗体:

Cell Viability Assay[1]

Cell Line: H₂O₂-induced PC12 cells
Concentration: 50 μM
Incubation Time: 24 h
Result: Increased H₂O₂-induced PC12 cell viability to 91.48% (vs. 41.43% in the model group) at 50 μM.

Western Blot Analysis[1]

Cell Line: H₂O₂-induced PC12 cells
Concentration: 2.5, 5 and 10 μM
Incubation Time: 24 h
Result: Decreased cytoplasmic Keap1 and Nrf2 levels.
Increased nuclear Nrf2 levels.
Upregulated HO-1 and NQO1 expression.
Reduced the Bax/Bcl-2 ratio.

Immunofluorescence[1]

Cell Line: H₂O₂-induced PC12 cells
Concentration: 2.5, 5 and 10 μM
Incubation Time: 24 h
Result: Increased nuclear Nrf2 fluorescence intensity in H₂O₂-induced PC12 cells.
分子量

1271.44

Formula

C60H102O28
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Ginsenoside Ia 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ginsenoside IaReactive Oxygen Species (ROS)ApoptosisKeap1-Nrf2Heme Oxygenase (HO)Bcl-2 FamilyHeme OxygenaseKeap1PC12 cellsNrf2ROSapoptosisPanax quinquefolium L.neurodegenerative diseasesNQO1neuronal damageHO-1Inhibitorinhibitorinhibit

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