2. Metabolic Enzyme/Protease
  3. HMG-CoA Reductase (HMGCR)
  4. Glenvastatin

Glenvastatin (HR 780) 是一种具有口服活性的 3-羟基-3-甲基戊二酰辅酶 A (HMG-CoA) 还原酶抑制剂。Glenvastatin 能够降低血浆总胆固醇和磷脂水平以及肝脏胆固醇含量。Glenvastatin 不会增加胆囊胆汁中胆固醇和总胆汁酸的含量。Glenvastatin 可用于高脂血症的研究

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Glenvastatin

Glenvastatin Chemical Structure

CAS No. : 122254-45-9

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Glenvastatin 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Glenvastatin (HR 780) is an orally active 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor. Glenvastatin can reduces plasma total cholesterol and phospholipid levels and liver cholesterol contents. Glenvastatin does not increase the contents of cholesterol and total bile acid in the gallbladder bile. Glenvastatin can be used for the research of hyperlipemia[1]

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HepG2 IC50
5 nM
Compound: 2i
Inhibition of cellular HMG-CoA reductase in cultures of human HEP G2 cells, determined by decreased incorporation of sodium [14C]acetate into cholesterol.
Inhibition of cellular HMG-CoA reductase in cultures of human HEP G2 cells, determined by decreased incorporation of sodium [14C]acetate into cholesterol.
[PMID: 2296036]
分子量

431.50

Formula

C27H26FNO3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Glenvastatin 相关分类

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  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Glenvastatin122254-45-9HR 780HR780HR-780HMG-CoA Reductase (HMGCR)Inhibitorinhibitorinhibit

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