2. Immunology/Inflammation Vitamin D Related/Nuclear Receptor NF-κB
  3. Glucocorticoid Receptor NF-κB AP-1
  4. Glucocorticoid receptor modulator 5

Glucocorticoid receptor modulator 5 (Compound D8) 是一种选择性、口服有效的糖皮质激素受体 (Glucocorticoid receptor) 调节剂。Glucocorticoid receptor modulator 5 显示出极高的转录抑制活性 (TRNF-κB IC50 = 0.0009 μM，TRAP-1 IC50 = 0.0005 μM)。Glucocorticoid receptor modulator 5 通过直接与糖皮质激素受体信号通路相互作用发挥其抗炎活性。Glucocorticoid receptor modulator 5 可显著缓解皮炎和自身免疫性肝炎。

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Glucocorticoid receptor modulator 5

Glucocorticoid receptor modulator 5 Chemical Structure

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Glucocorticoid receptor modulator 5 相关抗体

Top Publications Citing Use of Products

查看 NF-κB 亚型特异性产品:

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NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

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c-Fos FosB Fra1/FOSL1 Fra2/FOSL2 c-Jun

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Glucocorticoid receptor modulator 5 (Compound D8) is a selective, orally active Glucocorticoid receptor modulator. Glucocorticoid receptor modulator 5 shows extremely high transrepression activity (TRNF-κB IC50 = 0.0009 μM, TRAP-1 IC50 = 0.0005 μM). Glucocorticoid receptor modulator 5 exerts its anti-inflammatory activity by interacting directly with the Glucocorticoid receptor signaling pathway. Glucocorticoid receptor modulator 5 significantly alleviates dermatitis and autoimmune hepatitis[1].

分子量

470.97

Formula

C24H23ClN2O4S
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Glucocorticoid receptor modulator 5 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Glucocorticoid receptor modulator 5Glucocorticoid receptor modulator5Glucocorticoid receptor modulator-5Glucocorticoid ReceptorNF-κBAP-1Nuclear factor-κBNuclear factor-kappaBActivator Protein 1anti-inflammatorydermatitisautoimmune hepatitisInhibitorinhibitorinhibit

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