2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. iGluR
  4. GluN2B-NMDAR Allosteric modulator 1

GluN2B-NMDAR Allosteric modulator 1 是一种选择性 GluN2B-NMDAR 正向变构调节剂。GluN2B-NMDAR Allosteric modulator 1 可增强谷氨酸和天冬氨酸诱发的 GluN2B-NMDAR 门控电流，其 EC50 值分别为 43.7 nM 和 18 nM。GluN2B-NMDAR Allosteric modulator 1 可逆转小鼠的焦虑样行为和社会认知缺陷。GluN2B-NMDAR Allosteric modulator 1 可用于神经系统疾病的研究，如焦虑症 。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

GluN2B-NMDAR Allosteric modulator 1

GluN2B-NMDAR Allosteric modulator 1 Chemical Structure

CAS No. : 2419700-58-4

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Customer Review

GluN2B-NMDAR Allosteric modulator 1 相关抗体

Top Publications Citing Use of Products

查看 iGluR 亚型特异性产品:

查看所有亚型
AMPA Receptor NMDA Receptor Kainate Receptor

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

GluN2B-NMDAR Allosteric modulator 1 is a selective GluN2B-NMDAR positive allosteric modulator. GluN2B-NMDAR Allosteric modulator 1 can increase glutamate- and aspartate-evoked GluN2B-NMDAR-gated currents with EC50 values of 43.7 and 18 nM. GluN2B-NMDAR Allosteric modulator 1 can reverse anxiety-like behavior and social cognition deficits in mice. GluN2B-NMDAR Allosteric modulator 1 can be used for the research of neurological disease, such as anxiety[1].

IC50 & Target[1]

GluN2B

 

体外研究
(In Vitro)

GluN2B-NMDAR Allosteric modulator 1 (Compound 175) (0.001-100 μM) 可升高 HEK293 细胞中谷氨酸诱导的 GluN1/GluN2B-NMDAR 门控电流，其 EC50 为 43.7 nM (logEC50 = -7.36)[1]。
GluN2B-NMDAR Allosteric modulator 1 (0.0001-1 μM) 可在原代大鼠海马神经元中呈剂量依赖性且选择性地增强天冬氨酸诱发的含 GluN2B 的天然 NMDAR 电流，其 EC50 为 18 nM[1]。
GluN2B-NMDAR Allosteric modulator 1 (1 μM；3 h) 不会在原代皮质神经元中诱导细胞毒性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

GluN2B-NMDAR Allosteric modulator 1 相关抗体:
体内研究
(In Vivo)

GluN2B-NMDAR Allosteric modulator 1 (Compound 175) (1 mg/kg；腹腔注射；突触可塑性诱导前 30 分钟给药) 可通过依赖含 GluN2B 的 NMDAR 的机制，在麻醉大鼠中促进低频刺激诱导的长时程抑郁[1]。
GluN2B-NMDAR Allosteric modulator 1 (1 mg/kg；腹腔注射；单次给药) 可逆转 7 月龄 Mecp2-OE 小鼠以及携带可诱导表达达 Disc1-N 的转基因小鼠品系的焦虑样行为与社会认知缺陷[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Mecp2-OE mice (7 months old); a transgenic mouse line harboring an inducible expression of Disc1-N mice (C57BL/6; 3-4 months old) [1]
Dosage: 1 mg/kg
Administration: I.p.; single dose (30 minutes before each behavioral test)
Result: Restored center time in the open-field test to WT levels (reversing anxiety-like behavior) and significantly improved social preference index in Mecp2-OE mice.
Increased time spent in the center of the open-field test (reversing anxiety-like behavior), increased spontaneous alternation in the Y-maze test (improving spatial working memory) and increased social preference index in the three-chamber test (reversing sociability deficit) in Disc1-N mice.
分子量

295.38

Formula

C17H21N5
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

GluN2B-NMDAR Allosteric modulator 1 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GluN2B-NMDAR Allosteric modulator 12419700-58-4iGluRIonotropic glutamate receptorsGluN2BNMDARsGluN2Dlong-term depressionInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
GluN2B-NMDAR Allosteric modulator 1
目录号：
HY-181127
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z