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Glycerophospholipids, cephalins 

目录号: HY-148123 纯度: 88.59%
COA 产品使用指南 技术支持

Glycerophospholipids, cephalins 是一类磷脂化合物，是神经膜的重要组成成分。Glycerophospholipids, cephalins 是磷脂酶 (如 PLA2、PLC、PLD) 的水解底物，完全水解后分别生成 1 mol 甘油、磷酸、乙醇胺和 2 mol 脂肪酸。Glycerophospholipids, cephalins 可维持膜结构、流动性及离子通透性，并作为花生四烯酸和二酰甘油等第二信使的前体。Glycerophospholipids, cephalins 可调控信号转导、细胞凋亡和膜运输，应用于神经退行性疾病 (如阿尔茨海默病) 的研究。

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Glycerophospholipids, cephalins

Glycerophospholipids, cephalins Chemical Structure

CAS No. : 39382-08-6

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Glycerophospholipids, cephalins 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Glycerophospholipids and cephalins are a class of phospholipid compounds and important components of neural membranes. Glycerophospholipids and cephalins are hydrolysis substrates of phospholipase (such as PLA2, PLC, and PLD). After complete hydrolysis, they produce 1 mol of glycerol, phosphate, ethanolamine, and 2 mol of fatty acids, respectively. Glycerophospholipids and cephalins can maintain membrane structure, fluidity, and ion permeability, and serve as precursors of second messengers such as arachidonic acid and diacylglycerol. Glycerophospholipids and cephalins can regulate signal transduction, cell apoptosis, and membrane transport, and are used in the study of neurodegenerative diseases (such as Alzheimer's disease)[1][2].

体外研究
(In Vitro)

Glycerophospholipids, cephalins (50 μM；24 h) 通过激活磷脂酶 PLA2 并释放花生四烯酸，增加大鼠皮质神经元的凋亡率[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Glycerophospholipids, cephalins 相关抗体:

Cell Viability Assay[2]

Cell Line: Rat hippocampal neurons
Concentration: 20 μM
Incubation Time: 12 h
Result: Increased phosphorylation of PKC and ERK1/2, indicating activation of the PLC/DAG signaling pathway.
体内研究
(In Vivo)

Glycerophospholipids, cephalins (3 个月 DHA 饮食；饮食干预；每日；3 个月) 在雌性 APP/PS1 转基因小鼠在显著减少皮质和海马区淀粉样斑块负荷，并增加海马区 drebrin 水平[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Tg2576 mice (male, weight 18-22g, 6 months old) with Alzheimer’s disease model[1]
Dosage: 100 mg/kg Arachidonic acid (Glycerophospholipids, cephalins metabolism)
Administration: Intraperitoneal injection, once daily, 4 weeks
Result: Induced significant increase in brain F₂-isoprostane levels and promoted Aβ1-42 aggregation, leading to cognitive impairment.
CAS 号
性状

固体

颜色

Off-white to light yellow

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
细胞实验： 

THF 中的溶解度 : ≥ 100 mg/mL

* "≥" means soluble, but saturation unknown.

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: 88.59%

COA (278 KB)

产品使用指南 (1538 KB)
参考文献

Glycerophospholipids, cephalins 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Glycerophospholipids, cephalins39382-08-6Biochemical Assay ReagentsInhibitorinhibitorinhibit

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// var stopn2 = $(window).scrollTop() - initStopn; // var promise = $("#main_nav").offset().top; // var winheight= ($(window).height()); // var promisepro = 716; // // // // if (stopn >= promise) { // $('.pro_mask').css("top","88px"); // } // else { // $('.pro_mask').css("top","120px"); // } // // if (winheight < promisepro) { // if (stopn2 > 0) { // if (targetTop > 368) { // targetTop = targetTop - stopn2 <= 368 ? 368 : targetTop - stopn2; // } // } // } else { // if (stopn2 < 0) { // targetTop = targetTop - stopn2 >= 537 ? 537 : targetTop - stopn2; // } // loginDivheight = 430; // $('.pro_login').removeClass('divlogoverflow'); // } // // if (targetTop <= 368) { // let h1 = 650 - winheight; // let new_loginDivheight = h1 >= 0 ? 430 - h1 : 430 ; // $('.pro_login').height(new_loginDivheight); // let c_h = loginDivheight - new_loginDivheight; // targetTop = targetTop - c_h / 2; // loginDivheight = new_loginDivheight; // if (new_loginDivheight < 430) { // $('.pro_login').addClass('divlogoverflow'); // } else { // $('.pro_login').removeClass('divlogoverflow'); // } // // } // // $('.pro_login').css("top", targetTop + "px"); // initStopn = $(window).scrollTop(); // } var sel_array = $('[name="pro_cart_mg_num"]'); var mg_array = $('[name="pro_cart_mg"]'); var dw_sel_array = $('[name="pro_cart_dw_num"]'); var dw_array = $('[name="pro_cart_dw"]'); var eta_showStockType = "1"; var eta_infringementType = "0"; function updateProETA(){ var isChange = false; var isPrepare = false; var isETA = false; // var sel_num = $(currentE).val(); // if (parseInt(sh_stock_num) < parseInt(sel_num)) { // $('#pro_detail_eta').show(); // $('#pro_detail_eta').html(getEtaCnMessage()); // } else { // $('#pro_detail_eta').hide(); // $('#pro_detail_eta').html(""); // } var delivery = ''; dw_sel_array.each(function(index,domEle) { var option_dw = $(dw_array.eq(index)).val().split(";"); var dw_sh_stock_num = option_dw[6]; var dw_us_stock_num = option_dw[7]; var dw_select_num = $(domEle).val(); if (parseInt(dw_sh_stock_num) < parseInt(dw_select_num)) { isETA = true; if (dw_us_stock_num == 9527) { isChange = true; } if (dw_us_stock_num == 99999) { isPrepare = true; } delivery = $(domEle).closest('tr').find('.pro_price_3').text() return false; } }); //alert('isDW:'+isDW); sel_array.each(function(index,domEle){ var select_num = $(domEle).val(); var option_mg = $(mg_array.eq(index)).val().split(";"); var sh_stock_num = option_mg[6]; var us_stock_num = option_mg[7]; var eta_message = ''; if (parseInt(sh_stock_num) < parseInt(select_num)) { isETA = true; if (us_stock_num == 9527) { isChange = true; } if (us_stock_num == 99999) { isPrepare = true; } delivery = $(domEle).closest('tr').find('.pro_price_3').text() return false; } }); // 20200519 wdf if (isETA == true) { if (isPrepare || isChange) { $('#pro_detail_eta').html("预计 " + delivery + " 发货"); } else { var catNo = "HY-148123"; changeCnEtaMessage(isChange); //$('#pro_detail_eta').show(); $('#pro_detail_eta').html(getEtaCnMessage(catNo, isChange)); } } else { //$('#pro_detail_eta').hide(); $('#pro_detail_eta').html(""); } } function qtyChange(){ updateProETA(); } // Product Isoform by WDF 20180508 $(function () { fnSetIC50Style(); fnIsoformWidth(); proRelatedImgCN(); //normalSalineDisplacement(); }); // Isoform width function fnIsoformWidth(){ var isoformProList = $(".isoform-pro-list"); var isoformProListLen = isoformProList.length; for(var i = 0; i < isoformProListLen; i++){ var isoformProSpan = isoformProList.eq(i).find("span"); var isoformProSpanLen = isoformProSpan.length; if(isoformProSpanLen>4) { isoformProSpan.parent().css({"width":"100%"}); isoformProSpan.css({"width":"auto"}); } else { isoformProSpan.parent().css({"width":(isoformProSpanLen/4*100)+"%" }); isoformProSpan.css({"width":(1/isoformProSpanLen*100)+"%" }); } } } /* * Target&IC50 Table => 原理 * 1. 计算每个格子的宽度，如果格子的总宽度 <= iContainerW(固定行宽)，则一行显示; 否则多行显示 * 2. 多行的情况: 列数 = iContainerW/最宽单元格的列宽(取整); 列宽 = iContainerW/列数 * 3. 如果一行中, IC50值全是空，那么这一行 IC50 全隐藏，Isoform 垂直居中对齐 */ function fnSetIC50Style(){ var oContainer = $("#pro-ic50-tbl"); var iContainerW = 827; var spanLen = oContainer.find("span").length; var tdLen = spanLen/2; // 单元格总数 var spanArr = []; var spanTotalW = 0; var spanwMax = 0; // span 相加总长度 var lastW = 0; if(tdLen > 1){ for(var i = 0; i < tdLen; i++){ var spanW = [oContainer.find("td").eq(i).find("span").eq(0).outerWidth(),oContainer.find("td").eq(i).find("span").eq(1).outerWidth()].max(); spanArr.push(spanW); spanTotalW += spanW; if(i==tdLen-1){ lastW = oContainer.find("td").eq(i).find("span").eq(0).outerWidth(); } } } spanwMax = spanArr.max(); // console.log("spanwMax= " + spanwMax); // console.log("spanArr=" +spanArr); // 如果 spanwMax > iContainerW 分行; 否则, 一行显示 if(spanTotalW <= iContainerW){ oContainer.find("td").addClass("ic50-td0"); oContainer.find("td:last-child").css({"width": (iContainerW-lastW)+"px"}); // 最后一列宽度 oContainer.find(".ic50-td0").wrapAll(""); }else { var trtdNum = parseInt(iContainerW / spanwMax); // 每一行的列数 var tdWidth = iContainerW/trtdNum; //列宽 var trLen = spanLen/2/trtdNum; // 总行数 var lastTrNum = spanLen/2%trtdNum; //最后一行的个数 var lastColspan = trtdNum+1-lastTrNum; // 最后一行需要合并的单元格数 for (var j = 0; j < tdLen; j++) { for (var k = 0; k < trLen; k++) { if (parseInt(j / trtdNum) == k) { oContainer.find("td").eq(j).addClass("ic50-td" + k); } } } oContainer.find("td").css({"width": tdWidth + "px"}); // 设置列宽 oContainer.find("td:last-child").attr({"colspan": lastColspan}); //最后一行合并的单元格数量 oContainer.find("td:last-child").css({"width": lastColspan*tdWidth+"px"}); // 最后一列宽度 // tr 分组 for (var k = 0; k < trLen; k++) { oContainer.find(".ic50-td" + k).wrapAll(""); } } oContainer.find("td.ic50-td0 > p:first-child").css({"border-top":"0"}); // 第一行 p 的上border 是0 // 如果一行中 IC50 全是空，则这一行隐藏 var iTrLength = oContainer.find("tr>tr").length; var str = []; var tdLength = 0; console.log("tr="+iTrLength); for(var a = 0; a < iTrLength; a++){ tdLength = oContainer.find("tr>tr").eq(a).find("td").length; for(var b = 0; b < tdLength; b++ ){ var aa = oContainer.find("tr>tr").eq(a).find("td").eq(b).find("p").eq(1).text().replace(/\,|(^\s*)|(\s*$)/g, ""); str[a] += aa; } console.log("str[a]="+str[a]); if(str[a] == "undefined" || str[a] == "" || str[a] == null){ for(var b = 0; b < tdLength; b++ ){ oContainer.find("tr>tr").eq(a).find("td").eq(b).find("p").eq(1).css({"display":"none"}); oContainer.find("tr>tr").eq(a).find("td").eq(b).find("p").eq(0).css({"padding":"0"}); oContainer.find("tr>tr").eq(a).find("td").eq(b).find("p").eq(0).find("span").css({"padding":"8px 18px 6px"}); } } } } //最小值 Array.prototype.min = function() { var min = this[0]; var len = this.length; for (var i = 1; i < len; i++){ if (this[i] < min){ min = this[i]; } } return min; } //最大值 Array.prototype.max = function() { var max = this[0]; var len = this.length; for (var i = 1; i < len; i++){ if (this[i] > max) { max = this[i]; } } return max; } Number.prototype.toFloor = function (num) { return Math.floor(this * Math.pow(10, num)) / Math.pow(10, num); }; // end Product Isoform by WDF 20180203 //0){ return false; } else{ var count=$("#iqDetail_productCount").val().trim(); 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pdf_array.push(pdf_obj); } }else if(arrPdf[i].objFile=="RP-HPLC"){ if (isShowPT) { coa_txt = coa_txt + "RP-HPLC ("+arrPdf[i].objSize+" KB)"; } else { coa_txt = coa_txt + "RP-HPLC ("+arrPdf[i].objSize+" KB)"; var pdf_obj = new $.PdfObj('J-RP-HPLC-link', arrPdf[i].objName, 'RP-HPLC', catalogNo, lot_batch); pdf_array.push(pdf_obj); } }else if(arrPdf[i].objFile=="NP-HPLC"){ if (isShowPT) { coa_txt = coa_txt + "NP-HPLC ("+arrPdf[i].objSize+" KB)"; } else { coa_txt = coa_txt + "NP-HPLC ("+arrPdf[i].objSize+" KB)"; var pdf_obj = new $.PdfObj('J-NP-HPLC-link', arrPdf[i].objName, 'NP-HPLC', catalogNo, lot_batch); pdf_array.push(pdf_obj); } }else if(arrPdf[i].objFile=="MS"){ if (isShowPT) { coa_txt = coa_txt + "MS ("+arrPdf[i].objSize+" KB)"; } else { coa_txt = coa_txt + "MS ("+arrPdf[i].objSize+" KB)"; var pdf_obj = new $.PdfObj('J-MS-link', arrPdf[i].objName, 'MS', catalogNo, lot_batch); pdf_array.push(pdf_obj); } }else if(arrPdf[i].objFile=="LCMS"){ if (isShowPT) { coa_txt = coa_txt + "LCMS ("+arrPdf[i].objSize+" KB)"; } else { coa_txt = coa_txt + "LCMS ("+arrPdf[i].objSize+" KB)"; var pdf_obj = new $.PdfObj('J-LCMS-link', arrPdf[i].objName, 'LCMS', catalogNo, lot_batch); pdf_array.push(pdf_obj); } }else if(arrPdf[i].objFile=="IR"){ if (isShowPT) { coa_txt = coa_txt + "IR ("+arrPdf[i].objSize+" KB)"; } else { coa_txt = coa_txt + "IR ("+arrPdf[i].objSize+" KB)"; var pdf_obj = new $.PdfObj('J-IR-link', arrPdf[i].objName, 'IR', catalogNo, lot_batch); pdf_array.push(pdf_obj); } }else if(arrPdf[i].objFile=="GC"){ if (isShowPT) { coa_txt = coa_txt + "GC ("+arrPdf[i].objSize+" KB)"; } else { coa_txt = coa_txt + "GC ("+arrPdf[i].objSize+" KB)"; var pdf_obj = new $.PdfObj('J-GC-link', arrPdf[i].objName, 'GC', catalogNo, lot_batch); pdf_array.push(pdf_obj); } }else if(arrPdf[i].objFile=="OR"){ if (isShowPT) { coa_txt = coa_txt + "OR ("+arrPdf[i].objSize+" KB)"; } else { coa_txt = coa_txt + "OR ("+arrPdf[i].objSize+" KB)"; var pdf_obj = new $.PdfObj('J-OR-link', arrPdf[i].objName, 'OR', catalogNo, lot_batch); pdf_array.push(pdf_obj); } }else if(arrPdf[i].objFile=="SDS-PAGE"){ if (isShowPT) { coa_txt = coa_txt + "SDS-PAGE ("+arrPdf[i].objSize+" KB)"; } else { coa_txt = coa_txt + "SDS-PAGE ("+arrPdf[i].objSize+" KB)"; var pdf_obj = new $.PdfObj('J-SDS-PAGE-link', arrPdf[i].objName, 'SDS-PAGE', catalogNo, lot_batch); pdf_array.push(pdf_obj); } }else if(arrPdf[i].objFile=="Other Report"){ if (isShowPT) { coa_txt = coa_txt + "Other Report ("+arrPdf[i].objSize+" KB)"; } else { coa_txt = coa_txt + "Other Report ("+arrPdf[i].objSize+" KB)"; var pdf_obj = new $.PdfObj('J-Other-Report-link', arrPdf[i].objName, 'Other Report', catalogNo, lot_batch); pdf_array.push(pdf_obj); } }else if(arrPdf[i].objFile=="SEC-HPLC"){ if (isShowPT) { coa_txt = coa_txt + "SEC-HPLC ("+arrPdf[i].objSize+" KB)"; } else { coa_txt = coa_txt + "SEC-HPLC ("+arrPdf[i].objSize+" KB)"; var pdf_obj = new $.PdfObj('J-SEC-HPLC-link', arrPdf[i].objName, 'SEC-HPLC', catalogNo, lot_batch); pdf_array.push(pdf_obj); } } }else{ if(arrPdf[i].objFile=="Purity"){ batch_txt += "纯度： " + arrPdf[i].objName ; } else if (arrPdf[i].objFile=="Assay") { batch_txt += "含量： " + arrPdf[i].objName; } else{ batch_txt += "ee.: " + arrPdf[i].objName ; } } } //pdf_batch.innerHTML = batch_txt; //pdf_coa.innerHTML = coa_txt; $("#productDetailBatch_pdf_batch").html(batch_txt); $("#productDetailBatch_pdf_coa").html(coa_txt); } } if (pdf_array.length>0) { $.each(pdf_array, function(index, pdfobjTemp){ //console.log(pdfobjTemp.pdfname); $("#" + pdfobjTemp.pdfid).click(function () { pagePdfObj = pdfobjTemp; pagePdfObj.proName = `Glycerophospholipids, cephalins`; $("#J-HNMR-form .title").html("Request for " + pagePdfObj.pdftype + " Report"); $("#J-HNMR-form #lotNo").val(pagePdfObj.lotNo); modalOpen("#J-HNMR-form"); getUserBaseMessage(); }); }); } } }); } function Gettext(obj){ var txt=obj.options[obj.options.selectedIndex].text; return txt; } cart_sart(); //]]> function findClinicalsByCatalogNo(){ var catalogNo = "HY-148123"; $.ajax({ url:'mce_productDetail!findClinicalsByCatalogNo.shtml?mathdom='+Math.random(), type: 'post', cache:false, data:{'pro_catalogNo':catalogNo}, dataType: 'json', success:function(data){ var str_head = "" + "" + "NCT Number" + "Sponsor" + "Condition" + "Start Date" + "Phase" + "" + "" + ""; var str_foot = ""; var str_content = ""; $.each(data, function(i, item) { if (i==3) { //alert(i+","+item.phase); str_content += " "; } str_content += "" + item.nctNumber + ""; str_content += "" + item.sponsorCollaberators + ""; str_content += "
" + item.activeCondition + "
"; str_content += "" + item.startDate + ""; str_content += "" + item.phase + ""; }); $('#clinical_seo').html(str_head + str_content + str_foot); proClinicalStyle(); } }) } $("#datasheet_url").show(); $("#datasheet_footer_url").show(); $("#datasheet_span").show(); $("#sds_url").show(); $("#sds_footer_url").show(); $("#sds_span").show(); function checkUrl(c_url,type_id) { /*$.ajax({ url:'mce_productDetail!chenkUrlStatus.shtml?mathdom='+Math.random(), type: 'post', cache:false, data:{'curl':c_url}, dataType: 'json', success:function(data){ if (data.checkUrl == "success") { $("#" + type_id + "_url").show(); $("#" + type_id + "_footer_url").show(); $("#" + type_id + "_span").show(); } } })*/ $.ajax({ url: c_url, type: 'get', cache: false, dataType: 'jsonp', processData: false, complete: function(response) { if (response.status == 200) { $("#" + type_id + "_url").show(); $("#" + type_id + "_footer_url").show(); $("#" + type_id + "_span").show(); } }, error: function(data) {} }); } $(function(){ ChangerProductPdf($("#pdf_batch_no option:selected").val()); fnCPDRelated('#J-cpd-related-lib'); //fnCPDRelated('#J-cpd-related-mol'); //findRelatedProArray(); var pmsOutSessionId = $.cookie('pms-out-init'); console.log(pmsOutSessionId) //遮罩层屏蔽 if (pmsOutSessionId != "" && pmsOutSessionId !=null && pmsOutSessionId != undefined){ $("#loginProLogin").hide(); $("#loginProGeneral").hide(); $("#main").removeClass("gray-text");//遮罩层 $("#detail_price_pro").removeClass("is-disabled");//按钮控制 // // $("#loginProGeneral").hide(); // $("#loginProMask").removeClass("pro_mask"); } }); (function($, h, c) { var a = $([]), e = $.resize = $.extend($.resize, {}), i, k = "setTimeout", j = "resize", d = j + "-special-event", b = "delay", f = "throttleWindow"; e[b] = 350; e[f] = true; $.event.special[j] = { setup : function() { if (!e[f] && this[k]) { return false } var l = $(this); a = a.add(l); $.data(this, d, { w : l.width(), h : l.height() }); if (a.length === 1) { g() } }, teardown : function() { if (!e[f] && this[k]) { return false } var l = $(this); a = a.not(l); l.removeData(d); if (!a.length) { clearTimeout(i) } }, add : function(l) { if (!e[f] && this[k]) { return false } var n; function m(s, o, p) { var q = $(this), r = $.data(this, d); r.w = o !== c ? o : q.width(); r.h = p !== c ? p : q.height(); n.apply(this, arguments) } if ($.isFunction(l)) { n = l; return m } else { n = l.handler; l.handler = m } } }; function g() { i = h[k](function() { a.each(function() { var n = $(this), m = n.width(), l = n.height(), o = $ .data(this, d); if (m !== o.w || l !== o.h) { n.trigger(j, [ o.w = m, o.h = l ]) } }); g() }, e[b]) } })(jQuery, this); $('#loginProLogin').on('mousedown', function() { $('#loginProLogin').css('cursor','grab') }); $('#loginProLogin').on('mouseup', function() { $('#loginProLogin').css('cursor','move') }); $('#loginProGeneral').on('mousedown', function() { $('#loginProGeneral').css('cursor','grab') }); $('#loginProGeneral').on('mouseup', function() { $('#loginProGeneral').css('cursor','move') });