2. Cell Cycle/DNA Damage Metabolic Enzyme/Protease Immunology/Inflammation NF-κB
  3. Checkpoint Kinase (Chk) Reactive Oxygen Species (ROS) DNA/RNA Synthesis
  4. Graviquinone

Graviquinone 是一种 Chk1 抑制剂。Graviquinone 对多种癌细胞有强细胞毒性。Graviquinone 具有绕过 ABCB1 介导的多药耐药、选择性损伤癌细胞 DNA 并调控 DNA 损伤应答的特性。Graviquinone 也可通过增加癌细胞 ROS 水平增强细胞毒性。Graviquinone 可用于肿瘤的研究。

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Graviquinone

Graviquinone Chemical Structure

CAS No. : 1383995-51-4

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Graviquinone 相关抗体

Top Publications Citing Use of Products

查看 Checkpoint Kinase (Chk) 亚型特异性产品:

查看所有亚型
Chk1 Chk2 BUBR1

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Graviquinone is a Chk1 inhibitor. Graviquinone exhibits potent cytotoxicity against various cancer cell lines. Graviquinone possesses the characteristics of bypassing ABCB1-mediated multidrug resistance, selectively damaging cancer cell DNA, and regulating the DNA damage response. Graviquinone can also enhance cytotoxicity by increasing ROS levels in cancer cells. Graviquinone can be used for cancer research[1].

分子量

194.18

Formula

C10H10O4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Graviquinone 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Graviquinone1383995-51-4Checkpoint Kinase (Chk)Reactive Oxygen Species (ROS)DNA/RNA SynthesisL5178MCF-7A549NCI-H460Inhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-180357
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