2. Apoptosis
  3. Apoptosis
  4. GRP75-IN-1

GRP75-IN-1 (Compound 33) 是一种抗子宫内膜癌 (Endometrial cancer, EC) 剂。GRP75-IN-1 可诱导子宫内膜癌细胞凋亡 (Apoptosis)。GRP75-IN-1 hydrochloride 通过靶向 GRP75 并破坏其与 IP3R 的相互作用来降低线粒体中的 Ca2+ 水平。GRP75-IN-1 抑制人子宫内膜癌细胞异种移植动物模型肿瘤的生长。GRP75-IN-1 可用于子宫内膜癌的研究。

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GRP75-IN-1

GRP75-IN-1 Chemical Structure

CAS No. : 2922680-16-6

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GRP75-IN-1 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

GRP75-IN-1 (Compound 33) is an anti-endometrial cancer (EC) agent. GRP75-IN-1 induces apoptosis in endometrial cancer cells. GRP75-IN-1 hydrochloride reduces mitochondrial Ca2+ levels by targeting GRP75 and disrupting its interaction with IP3R. GRP75-IN-1 inhibits tumor growth in human endometrial cancer xenograft animal models. GRP75-IN-1 can be used for research in endometrial cancer[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
Ishikawa IC50
0.99 μM
Compound: 33
Inhibition of cell proliferation in human Ishikawa cells incubated for 48 hrs by CCK-8 assay
Inhibition of cell proliferation in human Ishikawa cells incubated for 48 hrs by CCK-8 assay
[PMID: 39082833]
KLE IC50
3.18 μM
Compound: 33
Inhibition of cell proliferation in human KLE cells incubated for 48 hrs by CCK-8 assay
Inhibition of cell proliferation in human KLE cells incubated for 48 hrs by CCK-8 assay
[PMID: 39082833]
分子量

466.68

Formula

C27H38N4OS
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

GRP75-IN-1 相关分类

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  • Do most proteins show cross-species activity?

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Keywords:

GRP75-IN-12922680-16-6ApoptosisInhibitorinhibitorinhibit

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