2. Immunology/Inflammation
  3. Kallikrein
  4. GSK951

GSK951 是一种强效且具有选择性的激肽释放酶-5 (KLK5) 抑制剂，易于表皮给药。GSK951 对 KLK5 的 IC50 值为 250 pM，对 KLK7 和 KLK14 的选择性超过 100 倍。GSK951 能够减少经表皮水分流失，并降低促炎细胞因子的表达。GSK951 可用于炎症和免疫学研究，如 Netherton 综合征。

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GSK951

GSK951 Chemical Structure

CAS No. : 2393881-77-9

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规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

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Customer Review

GSK951 相关抗体

Top Publications Citing Use of Products

查看 Kallikrein 亚型特异性产品:

查看所有亚型
KLK1 KLK5 KLK8 KLK14 KLKB1 KLK10

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

GSK951 is a potent and selective Kallikrein-5 (KLK5) inhibitor amenable to epidermal delivery. GSK951 shows an IC50 of 250 pM for KLK5 and greater than 100-fold selectivity over KLK7 and KLK14. GSK951 can reduce transepidermal water loss, and decrease proinflammatory cytokine expression. GSK951 can be used for the researches of inflammation and immunology, such as Netherton syndrome[1].

IC50 & Target[1]

KLK5

250 pM (IC50)

分子量

441.21

Formula

C22H19BF3N3O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

GSK951 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GSK9512393881-77-9GSK 951GSK-951KallikreinKLKKallikrein-related peptidaseInhibitorinhibitorinhibit

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产品名称：
GSK951
目录号：
HY-150085
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