2. Metabolic Enzyme/Protease Immunology/Inflammation
  3. Glutathione S-transferase Interleukin Related
  4. GSTO1-IN-6

GSTO1-IN-6 是一种变构共价 GSTO1 抑制剂，IC50 为 457 nM。GSTO1-IN-6 显著降低人单核细胞来源巨噬细胞中 Lipopolysaccharides (LPS) (HY-D1056) 诱导的 IL-1β (IC50 为 1.9 μM) 和 IL-18 (IC50 为 10 μM) 分泌。GSTO1-IN-6 与 GSTO1-Cys32 共价结合，诱导构象变化和蛋白不稳定。GSTO1-IN-6 可用于炎症性疾病的研究。

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GSTO1-IN-6

GSTO1-IN-6 Chemical Structure

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GSTO1-IN-6 相关抗体

Top Publications Citing Use of Products

查看 Interleukin Related 亚型特异性产品:

查看所有亚型
IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22 IL-18

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

GSTO1-IN-6 is an allosteric and covalent GSTO1 inhibitor with an IC50 of 457 nM. GSTO1-IN-6 markedly reduces Lipopolysaccharides (LPS) (HY-D1056)-induced IL-1β (IC50 of 1.9 μM) and IL-18 (IC50 of 10. μM) secretion in human monocyte-derived macrophages. GSTO1-IN-6 covalently modifies GSTO1-Cys32, inducing conformational changes and protein destabilization. GSTO1-IN-6 can be used for the research of inflammatory diseases[1].

IC50 & Target[1]

GSTO1

457 nM (IC50)

IL-1β

 

IL-18

 

体外研究
(In Vitro)

GSTO1-IN-6 (compound A13) (1 μM；5-60 分钟) 在人和大鼠肝微粒体中表现出良好的代谢稳定性，在 Caco-2 细胞中表现出良好的通透性[1]。
GSTO1-IN-6 (2-10 μM；2 小时) 抑制小鼠 BMDMs 中 LPS 和 Nigericin (HY-127019) 诱导的 IL-1β 分泌[1]。
GSTO1-IN-6 (16 小时) 抑制人外周血单个核细胞来源的巨噬细胞中 LPS 和 Nigericin 诱导的 IL-1β 和 IL-18 的释放[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

GSTO1-IN-6 相关抗体:
分子量

353.36

Formula

C16H14F3N3OS
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

GSTO1-IN-6 相关分类

  • 摩尔计算器

  • 稀释计算器

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GSTO1-IN-6Glutathione S-transferaseInterleukin RelatedGlutathione transferasesGSTsILCys32NEK7Cys253GSTO1covalentinflammatorymetabolicpocketinhibitorPRM-basedsecretionliverNLRP3iodoacetamideABPPinflammasomehydrophobicdesthiobiotinselectivitytargetedspectrometrydiseasescysteineproinflammatoryhumanmacrophagesLPS-inducedmonocyte-derivedmassIL-1βIL-18microsomesstabilityInhibitorinhibit

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目录号：
HY-179635
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