2. Metabolic Enzyme/Protease NF-κB Immunology/Inflammation
  3. Glycosidase Reactive Oxygen Species (ROS)
  4. Guavinoside B

Guavinoside B 是一种具有口服活性的 α-葡萄糖苷酶 (α-glucosidase) 抑制剂，其 IC50 为 0.21 mM。Guavinoside B 可上调 Acetaminophen (HY-66005) 诱导的 Nrf2、GCLC 和 NQO1 的表达，降低 p-JNK 的表达，并减少细胞内 ROS 水平。Guavinoside B 可降低 Acetaminophen 诱导的血清 TNF-α 水平，减轻肝细胞浸润与坏死，并改善肝脏相关生化指标。Guavinoside B 可用于糖尿病和 Acetaminophen 诱导的肝损伤的研究。

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Guavinoside B

Guavinoside B Chemical Structure

CAS No. : 372955-18-5

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Guavinoside B 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Guavinoside B is an orally active α-glucosidase inhibitor with an IC50 of 0.21 mM. Guavinoside B upregulates the expressions of Nrf2, GCLC and NQO1 induced by Acetaminophen (HY-66005), downregulates the expression of p-JNK, and reduces intracellular ROS levels. Guavinoside B decreases serum TNF-α levels induced by Acetaminophen, alleviates hepatocellular infiltration and necrosis, and improves liver-related biochemical parameters. Guavinoside B is applicable to the research of diabetes and Acetaminophen-induced liver injury[1][2].

IC50 & Target[1]

α‑glucosidase

0.21 mM (IC50)

体外研究
(In Vitro)

Guavinoside B 可强效抑制纯化的 α-葡萄糖苷酶活性，其 IC50 为 0.21 mM[1]。
Guavinoside B (3.3-100 μM; 24 h) 无论是否经过 5 mM Acetaminophen (HY-66005) 处理，均不会影响 HepG2 细胞的活力[2]。
Guavinoside B (3.3-30 μM; 16 h) 可使 HepG2 细胞中 Acetaminophen 诱导的细胞内 ROS 积累量降低 28.6%，在 3.3 和 10 μM 浓度下的作用较弱且无统计学意义[2]。
Guavinoside B (10-30 μM; 16 h) 可上调未经处理的 HepG2 细胞中 Nrf2 和 GCLC 的 mRNA 表达；且 (3.3-30 μM; 16 h) 可上调经 Acetaminophen 处理的 HepG2 细胞中 Nrf2、GCLC 和 NQO1 的 mRNA 表达[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Guavinoside B 相关抗体:

Real Time qPCR[2]

Cell Line: HepG2 (human hepatocellular carcinoma cells)
Concentration: 3.3, 10, 30 μM (alone; co-treated with 5 mM Acetaminophen)
Incubation Time: 16 h
Result: Increased mRNA expression levels of Nrf2 and GCLC at 10 and 30 μM when used alone.
Showed no impact on NQO1 mRNA expression when used alone.
Increased mRNA expression levels of Nrf2, GCLC, and NQO1 at 3.3, 10, and 30 μM when used with Acetaminophen.

Western Blot Analysis[2]

Cell Line: HepG2 (human hepatocellular carcinoma cells)
Concentration: 3.3, 10, 30 μM (alone; co-treated with 5 mM Acetaminophen)
Incubation Time: 16 h
Result: Increased protein expression levels of Nrf2, GCLC, and NQO1 at 3.3, 10, and 30 μM when used alone.
Increased protein expression levels of Nrf2, GCLC, and NQO1 at 3.3, 10, and 30 μM when used with Acetaminophen compared to the Acetaminophen-only group.
体内研究
(In Vivo)

Guavinoside B (100 mg/kg/d; p.o.; daily; 7 consecutive days) 可通过激活 Nrf2 信号通路、抑制 JNK 磷酸化、使血清 TNF-α 降低 22.7%，并调控肝脏氧化应激及肝功能关键生物标志物恢复正常，对雄性 C57BL/6 小鼠中 Acetaminophen (HY-66005) 诱导的肝损伤发挥强效保肝作用[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6 (male, 7 weeks old) injected with Acetaminophen[2]
Dosage: 100 mg/kg/d
Administration: p.o.; daily; 7 consecutive days
Result: Markedly alleviated Acetaminophen-induced hepatic pathological changes, including reduced hepatocyte necrosis and inflammation around central venous lesions.
Significantly reduced serum AST and ALT levels.
Significantly reduced hepatic ROS and MDA levels, and reversed Acetaminophen-induced depletion of hepatic GSH and SOD.
Significantly increased hepatic mRNA expression of SOD1 and GPx1.
Significantly up-regulated hepatic mRNA and protein expression levels of Nrf2, GCLC, and NQO1.
Significantly reduced serum TNF-α levels from 35.3 pg/mL (Acetaminophen-only group) to 27.3 pg/mL, and significantly inhibited Acetaminophen-induced JNK phosphorylation in liver tissue.
分子量

572.51

Formula

C28H28O13
CAS 号
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Guavinoside B 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Guavinoside B372955-18-5GlycosidaseReactive Oxygen Species (ROS)JNKHepG2 cellsNrf2GCLCTNF-αNQO1α-glucosidaseC57BL/6 micegallic acidROSInhibitorinhibitorinhibit

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